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Autor:
Jane Larowe Sterner, Salvador Ventura, Jeffrey Lynn Larson, Josep Vendrell, Charles Lee Hershberger, Francesc X. Avilés, Virtudes Villegas
Publikováno v:
Journal of Biological Chemistry. 274:19925-19933
The proteolytic processing of pancreatic procarboxypeptidase B to a mature and functional enzyme is much faster than that of procarboxypeptidase A1. This different behavior has been proposed to depend on specific conformational features at the region
Publikováno v:
Journal of Biological Chemistry. 274:18011-18016
In a previous study, we demonstrated the occurrence of novel proteins modified with a diphytanylglyceryl group in thioether linkage in Halobacterium halobium (Sagami, H., Kikuchi, A., and Ogura, K. (1995) J. Biol. Chem. 270, 14851–14854). In this s
Publikováno v:
Journal of Biological Chemistry. 274:10213-10218
Although the molecular mechanism by which chloroquine exerts its effects on the malarial parasitePlasmodium falciparum remains unclear, the drug has previously been found to interact specifically with the glycolytic enzyme lactate dehydrogenase from
Publikováno v:
Journal of Biological Chemistry. 274:9648-9655
We previously raised an antibody (RA6.3) by an antiidiotypic approach which was designed to be directed against an amiloride binding domain on the epithelial Na+ channel (ENaC). This antibody mimicked amiloride in that it inhibited transepithelial Na
Autor:
Jerzy Silberring, Adam Dubin, Jan Potempa, Marcin Bugno, Daniel C. Nelson, James Travis, Agnieszka Banbula, Paweł Mak
Publikováno v:
Journal of Biological Chemistry. 274:9246-9252
Porphyromonas gingivalis possesses a complex proteolytic system, which is essential for both its growth and evasion of host defense mechanisms. In this report we characterized, both at a protein and genomic level, a novel peptidase of this system wit
Publikováno v:
Journal of Biological Chemistry. 274:7656-7667
Sulfated fucans are among the most widely studied of all the sulfated polysaccharides of non-mammalian origin that exhibit biological activities in mammalian systems. Examples of these polysaccharides extracted from echinoderms have simple structures
Autor:
Tetsuo Toraya, Koichi Mori
Publikováno v:
Journal of Biological Chemistry. 274:3372-3377
Adenosylcobalamin-dependent diol dehydratase of Klebsiella oxytoca undergoes suicide inactivation by glycerol, a physiological substrate. The coenzyme is modified through irreversible cleavage of its cobalt-carbon bond, resulting in inactivation of t
Autor:
Thomas Michel, Margaret Arstall, Ralph A. Kelly, Douglas J. Opel, Chantal Dessy, Olivier Feron
Publikováno v:
Journal of Biological Chemistry. 273:30249-30254
The endothelial isoform of nitric oxide synthase (eNOS) is dually acylated and thereby targeted to signal-transducing microdomains termed caveolae. In endothelial cells, eNOS interacts with caveolin-1, which represses eNOS enzyme activity. In cardiac
Publikováno v:
Journal of Biological Chemistry. 273:25804-25808
It has been previously shown that besides synthesizing nitric oxide (NO), neuronal and inducible NO synthase (NOS) generates superoxide (O-2) under conditions of L-arginine depletion. However, there is controversy regarding whether endothelial NOS (e
Publikováno v:
Journal of Biological Chemistry. 273:26447-26454
Two Gram-positive Tet proteins, TetA(L) from Bacillus subtilis and TetK from aStaphylococcus aureus plasmid, have previously been suggested to have multiple catalytic modes and roles. These include: tetracycline (Tc)-metal/H+ antiport for both protei