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Publikováno v:
Journal of Biological Chemistry. 294:16765-16775
Epithelial Na+ channel (ENaC)-mediated Na+ transport has a key role in the regulation of extracellular fluid volume, blood pressure, and extracellular [K+]. Among the thousands of human ENaC variants, only a few exist whose functional consequences ha
Publikováno v:
The Journal of Biological Chemistry
The extracellular domain of the nicotinic acetylcholine receptor isoforms formed by three α4 and two β2 subunits ((α4)3(β2)2 nAChR) harbors two high-affinity "canonical" acetylcholine (ACh) binding sites located in the two α4:β2 intersubunit in
Publikováno v:
Journal of Biological Chemistry. 292:14775-14785
Equilibrative nucleoside transporters (ENTs) translocate hydrophilic nucleosides across cellular membranes and are essential for salvage nucleotide synthesis and purinergic signaling. Unlike the prototypic human ENT members hENT1 and hENT2, which med
Autor:
Aarati Sriram, Alexander Kuryatov, Zhuang Jin, Jon Lindstrom, Paul J. Kenny, Jingyi Wang, Theodore M. Kamenecka
Publikováno v:
Journal of Biological Chemistry. 290:13907-13918
Neuronal nicotinic acetylcholine receptors containing α4, β2, and sometimes other subunits (α4β2* nAChRs) regulate addictive and other behavioral effects of nicotine. These nAChRs exist in several stoichiometries, typically with two high affinity
Autor:
Chengwu Chi, Xiaoqin Zou, Alyssa Moller, Jianmin Cui, Jingyi Shi, Chunguang Wang, Kelli McFarland, Longjin Yang, Xiao Yang, Min Li, Shan Chang
Publikováno v:
Journal of Biological Chemistry. 289:4735-4742
BK channel β subunits (β1-β4) modulate the function of channels formed by slo1 subunits to produce tissue-specific phenotypes. The molecular mechanism of how the homologous β subunits differentially alter BK channel functions and the role of diff
Autor:
Linda Lucero, Paul Whiteaker, Xiangning Chen, Ronald J. Lukas, M. Imad Damaj, Andrew A. George
Publikováno v:
Journal of Biological Chemistry. 287:25151-25162
Genome-wide studies have strongly associated a non-synonymous polymorphism (rs16969968) that changes the 398th amino acid in the nAChR α5 subunit from aspartic acid to asparagine (D398N), with greater risk for increased nicotine consumption. We have
Autor:
Megha Nagle, Sanjay K. Nigam, Wei Wu, Satish A. Eraly, Sun-Young Ahn, David M. Truong, Ankur V. Dnyanmote
Publikováno v:
Journal of Biological Chemistry. 286:243-251
The organic anion transporters OAT1 (SLC22A6, originally identified by us as NKT) and OAT3 (SLC22A8) are critical for handling many toxins, metabolites, and drugs, including antivirals (Truong, D. M., Kaler, G., Khandelwal, A., Swaan, P. W., and Niga
NMR structure and action on nicotinic acetylcholine receptors of water-soluble domain of human LYNX1
Autor:
Alexandra P. Krivolapova, Victor I. Tsetlin, Ekaterina N. Lyukmanova, Dmitry A. Dolgikh, Konstantin S. Mineev, Mikhail A. Shulepko, Vladimir Dolezal, Sergey Yu. Filkin, Mikhail P. Kirpichnikov, Helena Janickova, Zakhar O. Shenkarev, Dieter D’hoedt, Igor E. Kasheverov, Daniel Bertrand, Alexander S. Arseniev
Publikováno v:
Journal of Biological Chemistry; Vol 286
Discovery of proteins expressed in the central nervous system sharing the three-finger structure with snake α-neurotoxins provoked much interest to their role in brain functions. Prototoxin LYNX1, having homology both to Ly6 proteins and three-finge
Publikováno v:
Journal of Biological Chemistry. 285:33898-33905
Kv2.1 channels, which are expressed in brain, heart, pancreas, and other organs and tissues, are important targets for drug design. Flecainide and propafenone are known to block Kv2.1 channels more potently than other Kv channels. Here, we sought to
Autor:
Stefan Gründer, Dominik Wiemuth
Publikováno v:
Journal of Biological Chemistry. 285:30404-30410
Ion channels of the degenerin/epithelial Na(+) channel gene family are Na(+) channels that are blocked by the diuretic amiloride and are implicated in several human diseases. The brain liver intestine Na(+) channel (BLINaC) is an ion channel of the d