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Autor:
Thomas M. Petro, Amy Lingel, Beka Solomon, Yuval Gavriel, Haishuang Lin, Yuguo Lei, Virginia Lopez, Pascal Polepole, Chi Zhang, Luwen Zhang, Eric A. Weaver
Publikováno v:
J Biol Chem
Zika virus (ZIKV) is a neurotropic flavivirus that causes several diseases including birth defects such as microcephaly. Intrinsic immunity is known to be a frontline defense against viruses through host anti-viral restriction factors. Limited knowle
Autor:
Sukanya Chakravarty, R. Travis Taylor, Sonam Popli, Gayatri Subramanian, Saurabh Chattopadhyay, Ritu Chakravarti
Publikováno v:
J Biol Chem
The interferon system is the first line of defense against virus infection. Recently, using a high-throughput genetic screen of a human interferon-stimulated gene short-hairpin RNA library, we identified a viral restriction factor, TDRD7 (Tudor domai
Autor:
Yue-Yi Wang, Aifu Lin, Jian-Zhong Shao, Tong Shao, Li-Xin Xiang, Dong-Dong Fan, Jiang-yuan Li
Publikováno v:
J Biol Chem
The NLR family pyrin domain containing 3 (NLRP3) inflammasome is one of the best-characterized inflammasomes in humans and other mammals. However, knowledge about the NLRP3 inflammasome in nonmammalian species remains limited. Here, we report the mol
Autor:
Santosh Kumar, Ved Prakash Dwivedi, Sandeep Rai Kaushik, Ankur Kulshreshtha, Gobardhan Das, Shivam Chaturvedi, Chetan Sharma, Ashima Bhaskar, Debprasad Chattopadhyay, Ranjan Kumar Nanda
Publikováno v:
J Biol Chem
The widespread availability and use of modern synthetic therapeutic agents have led to a massive decline in ethnomedical therapies. However, these synthetic agents often possess toxicity leading to various adverse effects. For instance, anti-tubercul
Autor:
Caiyong Chen, Yvette Y. Yien, Anthony S. Grillo, Stuart H. Orkin, Jiahai Shi, Jerry Kaplan, Matthew J. King, Jesmine T. M. Cheung, Paul D. Kingsley, Martin D. Burke, Barry H. Paw, Julien Ablain, John D. Phillips, Carla M. Koehler, Daniel E. Bauer, Leonard I. Zon, Martin D. Kafina, Liangtao Li, Diane M. Ward, Xuedi Zhang, Rishna Shrestha, Hojun Li, James Palis, Harvey F. Lodish
Publikováno v:
Yien, YY; Shi, J; Chen, C; Cheung, JT; Grillo, AS; Shrestha, R; et al.(2018). FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity.. The Journal of biological chemistry. doi: 10.1074/jbc.ra118.002742. UCLA: Retrieved from: http://www.escholarship.org/uc/item/0qr1j5bw
The Journal of biological chemistry, vol 293, iss 51
The Journal of biological chemistry, vol 293, iss 51
Erythropoietin (EPO) signaling is critical to many processes essential to terminal erythropoiesis. Despite the centrality of iron metabolism to erythropoiesis, the mechanisms by which EPO regulates iron status are not well-understood. To this end, he
Autor:
Balabhaskararao Kancharana, Thirumala-Devi Kanneganti, Min Zheng, Rajendra Karki, Hartmut Berns, Shondra M. Pruett-Miller
Publikováno v:
The Journal of Biological Chemistry
The innate immune system acts as the first line of defense against infection. One key component of the innate immune response to gram-negative bacterial infections is inflammasome activation. The caspase-11 (CASP11)-nucleotide-binding oligomerization
Publikováno v:
Journal of Biological Chemistry. 291:11373-11384
Mortality due to snakebite is a serious public health problem, and available therapeutics are known to induce debilitating side effects. Traditional medicine suggests that seeds of Mucuna pruriens can provide protection against the effects of snakebi
Autor:
Chengwu Chi, Xiaoqin Zou, Alyssa Moller, Jianmin Cui, Jingyi Shi, Chunguang Wang, Kelli McFarland, Longjin Yang, Xiao Yang, Min Li, Shan Chang
Publikováno v:
Journal of Biological Chemistry. 289:4735-4742
BK channel β subunits (β1-β4) modulate the function of channels formed by slo1 subunits to produce tissue-specific phenotypes. The molecular mechanism of how the homologous β subunits differentially alter BK channel functions and the role of diff
Autor:
Sally V. Catlett, Jonathan A. Harton, Meenakshi Malik, Elizabeth L. Westcott, Rachel J. Dotson, Sukalyani Banik, Seham M. Rabadi, Stephen Bradley, Chandra Shekhar Bakshi
Publikováno v:
Journal of Biological Chemistry. 288:23844-23857
Francisella tularensis is an important human pathogen responsible for causing tularemia. F. tularensis has long been developed as a biological weapon and is now classified as a category A agent by the Centers for Disease Control because of its possib
Publikováno v:
Journal of Biological Chemistry. 288:22451-22459
The primary pathological hallmark of Parkinson disease (PD) is the profound loss of dopaminergic neurons in the substantia nigra pars compacta. To facilitate the understanding of the underling mechanism of PD, several zebrafish PD models have been ge