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Autor:
Amber M. Paul, Jundi Wang, Ruoxing Wang, Dhiraj Acharya, Fengwei Bai, Faqing Huang, Yan-Lin Guo
Publikováno v:
Journal of Biological Chemistry. 288:15926-15936
Embryonic stem cells (ESCs) are considered to be a promising cell source for regenerative medicine because of their unlimited capacity for self-renewal and differentiation. However, little is known about the innate immunity in ESCs and ESC-derived ce
Autor:
Bryan Carson, Timothy S. Carpenter, Catherine S. Branda, Carol L. Kozina, Dianna Maar, Brooke Harmon, Oscar A. Negrete
Publikováno v:
Journal of Biological Chemistry. 288:8702-8711
The arenavirus nucleoprotein (NP) can suppress induction of type I interferon (IFN). This anti-IFN activity is thought to be shared by all arenaviruses with the exception of Tacaribe virus (TCRV). To identify the TCRV NP amino acid residues that prev
Publikováno v:
The Journal of Biological Chemistry
Europe PubMed Central
Europe PubMed Central
Background: Both tetrahydrobiopterin (BH4) and S-glutathionylation are important regulators of eNOS activity and coupling. Results: S-Glutathionylation and BH4 deficiency induce eNOS uncoupling through distinct mechanisms but are mutually regulated b
Autor:
Meenakshi Malik, Ellen B. Duffy, Jonathan A. Harton, Supriya Kar, Maninjay K. Atianand, Aaloki Shah
Publikováno v:
Journal of Biological Chemistry. 286:39033-39042
Pathogen-triggered activation of the inflammasome complex leading to caspase-1 activation and IL-1β production involves similar sensor proteins between mouse and human. However, the specific sensors used may differ between infectious agents and host
Autor:
Wenhe Zhong, Paul A.M. Michels, Malcolm D. Walkinshaw, Douglas S. Auld, Hugh P. Morgan, Iain W. McNae, Linda A. Fothergill-Gilmore, Matthew W. Nowicki
Publikováno v:
Journal of Biological Chemistry. 286:31232-31240
Ehrlich's pioneering chemotherapeutic experiments published in 1904 (Ehrlich, P., and Shiga, K. (1904) Berlin Klin. Wochenschrift 20, 329-362) described the efficacy of a series of dye molecules including trypan blue and trypan red to eliminate trypa
Autor:
Lech Ignatowicz, Xiang qun Ye, Dolores Gavier-Widén, Mahavir Singh, Berit Carow, Hans Wigzell, Akihiko Yoshimura, Wulf Oehlmann, Martin E. Rottenberg, Markus Sköld, Sabin Bhuju
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry; Vol 286
Journal of Biological Chemistry; Vol 286
Protection against infection with Mycobacterium tuberculosis demands IFN-γ. SOCS1 has been shown to inhibit responses to IFN-γ and might thereby play a central role in the outcome of infection. We found that M. tuberculosis is a highly efficient st
Publikováno v:
Journal of Biological Chemistry. 286:10568-10580
Retinoic acid-inducible gene I (RIG-I) recognizes RNA virus-derived nucleic acids, which leads to the production of type I interferon (IFN) in most cell types. Tight regulation of RIG-I activity is important to prevent ultra-immune responses. In this
Autor:
Megha Nagle, Sanjay K. Nigam, Wei Wu, Satish A. Eraly, Sun-Young Ahn, David M. Truong, Ankur V. Dnyanmote
Publikováno v:
Journal of Biological Chemistry. 286:243-251
The organic anion transporters OAT1 (SLC22A6, originally identified by us as NKT) and OAT3 (SLC22A8) are critical for handling many toxins, metabolites, and drugs, including antivirals (Truong, D. M., Kaler, G., Khandelwal, A., Swaan, P. W., and Niga
Autor:
Stefan Gründer, Dominik Wiemuth
Publikováno v:
Journal of Biological Chemistry. 285:30404-30410
Ion channels of the degenerin/epithelial Na(+) channel gene family are Na(+) channels that are blocked by the diuretic amiloride and are implicated in several human diseases. The brain liver intestine Na(+) channel (BLINaC) is an ion channel of the d
Autor:
Melissa Carroll, Zaruhi Stepanyan, Marie-Pierre Guimond, Siegfried Hekimi, Ying Wang, Abdelmadjid K. Hihi, Kevin M. McBride, Steve Hayes, Robyn Branicky
Publikováno v:
Journal of Biological Chemistry. 284:314-323
The development of neurodegenerative diseases such as Alzheimer, Parkinson, and Huntington disease is strongly age-dependent. Discovering drugs that act on the high rate of aging in older individuals could be a means of combating these diseases. Redu