Zobrazeno 1 - 10
of 42
pro vyhledávání: ''
Publikováno v:
Journal of Biological Chemistry. 294:1891-1903
The antibiotic trimethoprim is frequently used to manage Burkholderia infections, and members of the resistance-nodulation-division (RND) family of efflux pumps have been implicated in multidrug resistance of this species complex. We show here that a
Publikováno v:
Journal of Biological Chemistry. 293:4350-4365
Polymyxins such as colistin are antibiotics used as a final line of defense in the management of infections with multidrug-resistant Gram-negative bacteria. Although natural resistance to polymyxins is rare, the discovery of a mobilized colistin resi
Autor:
Mathias Winterhalter, Malcolm G. P. Page, Lucile Moynié, Harsha Bajaj, Matteo Ceccarelli, James H. Naismith, Mariano Andrea Scorciapino
Publikováno v:
Journal of Biological Chemistry. 291:2837-2847
Integral membrane proteins known as porins are the major pathway by which hydrophilic antibiotics cross the outer membrane of Gram-negative bacteria. Single point mutations in porins can decrease the permeability of an antibiotic, either by reduction
Autor:
Shu-Hong Yu, Matthias Wiens, Werner E.G. Müller, Alberto Manfrin, Vlad A. Grebenjuk, Xiaohong Wang, Ute Schlossmacher, Heinz C. Schröder, Michael Korzhev
Publikováno v:
Journal of Biological Chemistry
Silicateins are the key enzymes involved in the enzymatic polycondensation of the inorganic scaffold of the skeletal elements of the siliceous sponges, the spicules. The gene encoding pro-silicatein is inserted into the pCold TF vector, comprising th
Publikováno v:
Journal of Biological Chemistry. 281:25652-25658
Purine nucleoside phosphorylase (PNP) is an important component of the nucleotide salvage pathway in apicomplexan parasites and a potential target for drug development. The intracellular pathogen Toxoplasma gondii was therefore tested for sensitivity
Autor:
Barry Murphy, Patrick Caffrey, Barry J. Byrne, Maria Carmody, Dilip K. Rai, Bernard J. Rawlings, Patrick Power
Publikováno v:
Journal of Biological Chemistry. 280:34420-34426
Amphotericin B is a medically important antifungal antibiotic that is also active against human immunodeficiency virus, Leishmania parasites, and prion diseases. The therapeutic use of amphotericin B is restricted by severe side effects that can be m
Autor:
Valarie L. Tlapak-Simmons, Christina A. Baron, William M. Canfield, Paul H. Weigel, Russell Gotschall, Dewan Haque
Publikováno v:
Journal of Biological Chemistry. 280:13012-13018
Previous studies reached different conclusions about whether class I hyaluronan synthases (HASs) elongate hyaluronic acid (HA) by addition to the reducing or the nonreducing end. Here we used two strategies to determine the direction of HA synthesis
Publikováno v:
Journal of Biological Chemistry. 279:27799-27806
Daunorubicin and doxorubicin, two commonly used anticancer agents, are produced by the soil bacterium Streptomyces peucetius. Self-resistance to these antibiotics in S. peucetius is conferred by the drrAB locus that codes for two proteins, DrrA and D
Autor:
Paul R. Ortiz de Montellano, Huiying Li, Thomas L. Poulos, Shingo Nagano, Hideaki Shimizu, Clinton R. Nishida, Hiroshi Ogura
Publikováno v:
Journal of Biological Chemistry. 278:44886-44893
Epothilones are potential anticancer drugs that stabilize microtubules by binding to tubulin in a manner similar to paclitaxel. Cytochrome P450epoK (P450epoK), a heme containing monooxygenase involved in epothilone biosynthesis in the myxobacterium S
Autor:
Robert K. Poole, Martha Contreras-Zentella, Elizabeth Hernández-Urzúa, Edgardo Escamilla, Catherine E. Mills, Subhash G. Vasudevan, Gregory P. White, Jorge Membrillo-Hernández
Publikováno v:
Journal of Biological Chemistry. 278:34975-34982
Escherichia coli possesses a two-domain flavohemoglobin, Hmp, implicated in nitric oxide (NO) detoxification. To determine the contribution of each domain of Hmp toward NO detoxification, we genetically engineered the Hmp protein and separately expre