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Publikováno v:
Journal of Biological Chemistry. 294:1891-1903
The antibiotic trimethoprim is frequently used to manage Burkholderia infections, and members of the resistance-nodulation-division (RND) family of efflux pumps have been implicated in multidrug resistance of this species complex. We show here that a
Publikováno v:
Journal of Biological Chemistry. 293:4350-4365
Polymyxins such as colistin are antibiotics used as a final line of defense in the management of infections with multidrug-resistant Gram-negative bacteria. Although natural resistance to polymyxins is rare, the discovery of a mobilized colistin resi
Autor:
Barry Murphy, Patrick Caffrey, Barry J. Byrne, Maria Carmody, Dilip K. Rai, Bernard J. Rawlings, Patrick Power
Publikováno v:
Journal of Biological Chemistry. 280:34420-34426
Amphotericin B is a medically important antifungal antibiotic that is also active against human immunodeficiency virus, Leishmania parasites, and prion diseases. The therapeutic use of amphotericin B is restricted by severe side effects that can be m
Publikováno v:
Journal of Biological Chemistry. 288:26968
This is a response to a letter by Frere (1). Dr. Frere's letter and insightful comments are appreciated. We investigated the role of Arg-164 in the KPC-2 carbapenemase using biochemical and microbiological assays (2). Our variants were expressed in a
Publikováno v:
Journal of Biological Chemistry. 263:15880-15887
Resistance to lincomycin by inactivation has been detected in numerous clinical isolates of Staphylococcus; in crude extracts of Staphylococcus haemolyticus BM4610 and Staphylococcus aureus BM4611, inactivation of lincomycin and clindamycin requires
Autor:
Marie K. Murphy, Jerald G. Wooley
Publikováno v:
Journal of Biological Chemistry. 178:869-875
Publikováno v:
Journal of Biological Chemistry. 170:747-756
Publikováno v:
Journal of Biological Chemistry. 247:5279-5288
A variety of techniques have been employed to investigate the penicillin-binding components of Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, and Escherichia coli. Virtually all the binding sites in these organisms are located in the cell
Autor:
Robert C. Wood, George H. Hitchings
Publikováno v:
Journal of Biological Chemistry. 234:2377-2380