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Autor:
Santosh Kumar, Ved Prakash Dwivedi, Sandeep Rai Kaushik, Ankur Kulshreshtha, Gobardhan Das, Shivam Chaturvedi, Chetan Sharma, Ashima Bhaskar, Debprasad Chattopadhyay, Ranjan Kumar Nanda
Publikováno v:
J Biol Chem
The widespread availability and use of modern synthetic therapeutic agents have led to a massive decline in ethnomedical therapies. However, these synthetic agents often possess toxicity leading to various adverse effects. For instance, anti-tubercul
Autor:
Caiyong Chen, Yvette Y. Yien, Anthony S. Grillo, Stuart H. Orkin, Jiahai Shi, Jerry Kaplan, Matthew J. King, Jesmine T. M. Cheung, Paul D. Kingsley, Martin D. Burke, Barry H. Paw, Julien Ablain, John D. Phillips, Carla M. Koehler, Daniel E. Bauer, Leonard I. Zon, Martin D. Kafina, Liangtao Li, Diane M. Ward, Xuedi Zhang, Rishna Shrestha, Hojun Li, James Palis, Harvey F. Lodish
Publikováno v:
Yien, YY; Shi, J; Chen, C; Cheung, JT; Grillo, AS; Shrestha, R; et al.(2018). FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity.. The Journal of biological chemistry. doi: 10.1074/jbc.ra118.002742. UCLA: Retrieved from: http://www.escholarship.org/uc/item/0qr1j5bw
The Journal of biological chemistry, vol 293, iss 51
The Journal of biological chemistry, vol 293, iss 51
Erythropoietin (EPO) signaling is critical to many processes essential to terminal erythropoiesis. Despite the centrality of iron metabolism to erythropoiesis, the mechanisms by which EPO regulates iron status are not well-understood. To this end, he
Autor:
Balabhaskararao Kancharana, Thirumala-Devi Kanneganti, Min Zheng, Rajendra Karki, Hartmut Berns, Shondra M. Pruett-Miller
Publikováno v:
The Journal of Biological Chemistry
The innate immune system acts as the first line of defense against infection. One key component of the innate immune response to gram-negative bacterial infections is inflammasome activation. The caspase-11 (CASP11)-nucleotide-binding oligomerization
Publikováno v:
The Journal of Biological Chemistry
Europe PubMed Central
Europe PubMed Central
Background: Both tetrahydrobiopterin (BH4) and S-glutathionylation are important regulators of eNOS activity and coupling. Results: S-Glutathionylation and BH4 deficiency induce eNOS uncoupling through distinct mechanisms but are mutually regulated b
Autor:
Wenhe Zhong, Paul A.M. Michels, Malcolm D. Walkinshaw, Douglas S. Auld, Hugh P. Morgan, Iain W. McNae, Linda A. Fothergill-Gilmore, Matthew W. Nowicki
Publikováno v:
Journal of Biological Chemistry. 286:31232-31240
Ehrlich's pioneering chemotherapeutic experiments published in 1904 (Ehrlich, P., and Shiga, K. (1904) Berlin Klin. Wochenschrift 20, 329-362) described the efficacy of a series of dye molecules including trypan blue and trypan red to eliminate trypa
Autor:
Irene G. Huber, Jörg Striessnig, Jean-Charles Hoda, Edwin Wappl-Kornherr, Doris Walter-Bastl, Martina J. Sinnegger-Brauns
Publikováno v:
Journal of Biological Chemistry. 279:55211-55217
Replacement of L-type Ca(2+) channel alpha(1) subunit residue Thr-1066 in segment IIIS5 by a tyrosine residue conserved in the corresponding positions of non-L-type Ca(2+) channels eliminates high dihydropyridine sensitivity through a steric mechanis
Publikováno v:
Journal of Biological Chemistry. 274:19383-19388
Endoperoxide antimalarials based on the ancient Chinese drug Qinghaosu (artemisinin) are currently our major hope in the fight against drug-resistant malaria. Rational drug design based on artemisinin and its analogues is slow as the mechanism of act
Publikováno v:
Journal of Biological Chemistry. 274:9648-9655
We previously raised an antibody (RA6.3) by an antiidiotypic approach which was designed to be directed against an amiloride binding domain on the epithelial Na+ channel (ENaC). This antibody mimicked amiloride in that it inhibited transepithelial Na
Publikováno v:
Journal of Biological Chemistry. 268:25463-25468
A camptothecin-resistant (DC3F/C-10) Chinese hamster cell line that contains a catalytically altered and camptothecin (CPT)-resistant DNA topoisomerase I (top 1) (Tanizawa, A., and Pommier, Y. (1992) Cancer Res. 52, 1848-1854) and the parent cell lin
Publikováno v:
Europe PubMed Central
3'-Azido-2',3'-dideoxythymidine (AZT) and 2',3'-didehydro-2',3'-dideoxythymidine (D4T) are potent and selective inhibitors of human immunodeficiency virus replication in MT-4 and ATH8 cells. They are also inhibitory to the replication of murine retro