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Autor:
Elliot A. Philips, Benjamin G. Neel, Beatrix Ueberheide, Kieran Adam, Anna S. Tocheva, Marianne Strazza, Adam Mor, Inbar Azoulay-Alfaguter, Shalom Lerrer, Connor Foster, Michael Peled, Shruti Nayak
Publikováno v:
The Journal of Biological Chemistry
Programmed cell death protein 1 (PD-1) is a critical inhibitory receptor that limits excessive T cell responses. Cancer cells have evolved to evade these immunoregulatory mechanisms by upregulating PD-1 ligands and preventing T cell–mediated anti-t
Autor:
Mariëlle C. Haks, Timo Oosenbrug, Maaike E. Ressing, Michel J. van de Graaff, Sander I. van Kasteren
Publikováno v:
Journal of Biological Chemistry
J Biol Chem
Journal of Biological Chemistry, 295, 14325-14342
Journal of Biological Chemistry, 295(42), 14325-14342. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
J Biol Chem
Journal of Biological Chemistry, 295, 14325-14342
Journal of Biological Chemistry, 295(42), 14325-14342. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Surface-exposed Toll-like receptors (TLRs) such as TLR2 and TLR4 survey the extracellular environment for pathogens. TLR activation initiates the production of various cytokines and chemokines, including type I interferons (IFN-I). Downstream of TLR4
Autor:
Padmakar Tambare, Preeti Vishwakarma, Zaigham Abbas Rizvi, Rajesh Kumar, Praveen Sonkusre, Kanchana Chauhan, Sebanta Pokhrel, Naveen S Yadav, Tripti Shrivastava, Sweety Samal, Shubbir Ahmed, Manish Bansal, Supratik Das, Amit Awasthi
Publikováno v:
J Biol Chem
One strategy for the development of a next generation influenza vaccine centers upon using conserved domains of the virus to induce broader and long-lasting immune responses. The production of artificial proteins by mimicking native-like structures h
Autor:
Shoumo Bhattacharya, James R. O. Eaton, Gopala K. Yakala, Lucía Geis-Asteggiante, Graham Davies, Benoit Darlot, Kalimuthu Karuppanan, Akane Kawamura, Carol V. Robinson
Publikováno v:
The Journal of Biological Chemistry
Chemokines mediate leucocyte migration and homeostasis, and are key targets in inflammatory diseases including atherosclerosis, cytokine storm and chronic auto-immune disease. Chemokine redundancy and ensuing network robustness has frustrated therape
Autor:
Sukanya Chakravarty, R. Travis Taylor, Sonam Popli, Gayatri Subramanian, Saurabh Chattopadhyay, Ritu Chakravarti
Publikováno v:
J Biol Chem
The interferon system is the first line of defense against virus infection. Recently, using a high-throughput genetic screen of a human interferon-stimulated gene short-hairpin RNA library, we identified a viral restriction factor, TDRD7 (Tudor domai
Publikováno v:
The Journal of Biological Chemistry
Animal cells use pattern-recognition receptors (PRRs) to detect specific pathogens. Pathogen detection mounts an appropriate immune response, including interferon and cytokine induction. The intracellular PRR-signaling pathways that detect DNA viruse
Autor:
Yue-Yi Wang, Aifu Lin, Jian-Zhong Shao, Tong Shao, Li-Xin Xiang, Dong-Dong Fan, Jiang-yuan Li
Publikováno v:
J Biol Chem
The NLR family pyrin domain containing 3 (NLRP3) inflammasome is one of the best-characterized inflammasomes in humans and other mammals. However, knowledge about the NLRP3 inflammasome in nonmammalian species remains limited. Here, we report the mol
Autor:
Paul A. Ramsland, Mireille Vankemmelbeke, Jia Xin Chua, Andrew J. Guy, Richard S. McIntosh, Lindy G. Durrant, Caroline Soliman, Ian Spendlove
Publikováno v:
J Biol Chem
Cancer remains a leading cause of morbidity and mortality worldwide, requiring ongoing development of targeted therapeutics such as monoclonal antibodies. Carbohydrates on embryonic cells are often highly expressed in cancer and are therefore attract
Publikováno v:
The Journal of Biological Chemistry
Endoplasmic reticulum aminopeptidase 1 (ERAP1) and ERAP2 critically shape the major histocompatibility complex I (MHC I) immunopeptidome. The ERAPs remove N-terminal residues from antigenic precursor peptides and generate optimal-length peptides (i.e
Autor:
Aditya Dandekar, Tshifhiwa Magoro, Angelina R. Angelucci, Young S. Hahn, Gabriel Lipkowitz, Lucas T. Jennelle, Rohan Bajaj, Pascal O. Bessong
Publikováno v:
J Biol Chem
Zika virus (ZIKV)(3) is an enveloped, single-stranded, positive-sense RNA virus of the Flaviviridae family that has emerged as a public health threat because of its global transmission and link to microcephaly. Currently there is no vaccine for this