Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Christopher J. Schofield"'
Autor:
Emily Flashman, Holger B. Kramer, Nikita D. Loik, Christopher J. Schofield, Emily A. Howe, Hanna Tarhonskaya, James S. O. McCullagh, Adam P. Hardy
Publikováno v:
The Journal of Biological Chemistry
Background: The hypoxia-inducible factor (HIF) hydroxylases (FIH and PHDs) regulate hypoxia sensing in animals. Results: FIH·HIF-α reacts faster with O2 than PHD2·HIF-α but slower than FIH·ankyrin complexes. Conclusion: The kinetics of catalysis
Autor:
Michael A. McDonough, Holger B. Kramer, Timothy D. W. Claridge, Ming Yang, Wei Ge, Rasheduzzaman Chowdhury, Christopher J. Schofield, Bernhard Schmierer, Mathew L. Coleman, Peter J. Ratcliffe, Benedikt M. Kessler, Lingzhi Gong
Publikováno v:
Journal of Biological Chemistry
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Factor-inhibiting hypoxia-inducible factor (FIH) catalyzes the β-hydroxylation of an asparagine residue in the C-terminal transcriptional activation domain of the hypoxia inducible factor (HIF), a modification that negatively regulates HIF transcrip