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Publikováno v:
J Biol Chem
Peroxisome proliferator-activated receptor γ (PPARγ) is the central regulator of adipogenesis, and its dysregulation is linked to obesity and metabolic diseases. Identification of the factors that regulate PPARγ expression and activity is therefor
Autor:
Minghui Gao, Tianyu Wang, Shaoyang Zhao, Yuchan Mai, Xiaofen Zhong, Bing Long, Baoqiang Kang, Jiaming Gu, Dongwei Li, Jiekai Chen, Chuman Wu, Zechuan Liang, Qing Wang, Junwei Wang, Tian Zhang, Xiao Zhang, Yuhang Li, Yanqi Zhang, Guangjin Pan, Xiaodong Shu, Pengtao Wang, Yongli Shan, Baojian Liao, Jinfu Nie, Lin Guo, Qianyu Chen, Fang Wu, Ke Huang, Yanling Zhu, Jinbing Li, Duanqing Pei, Shuquan Su
Publikováno v:
J Biol Chem
Hematopoietic stem cells (HSCs)/progenitor cells (HPCs) are generated from hemogenic endothelial cells (HECs) during the endothelial-to-hematopoietic transition (EHT); however, the underlying mechanism remains poorly understood. Here, using an array
Autor:
David Kim, Mourad Ogbi, Yao Liang Tang, Ha Won Kim, Neal L. Weintraub, Abdalrahman Zarzour, David W. Stepp, Tyler W. Benson, Xin Yun Lu, Weiqin Chen, Samah Ahmadieh, Brandee Goo, Renee Hilton, Charlotte Greenway, Vijay Patel, David Y. Hui, Nicole K.H. Yiew
Publikováno v:
J Biol Chem
Enhancer of zeste homolog 2 (EZH2), an epigenetic regulator that plays a key role in cell differentiation and oncogenesis, was reported to promote adipogenic differentiation in vitro by catalyzing trimethylation of histone 3 lysine 27. However, inhib
Publikováno v:
J Biol Chem
The transcriptional cofactor nascent polypeptide-associated complex and co-regulator α (NACA) regulates osteoblast maturation and activity. NACA functions, at least in part, by binding to Jun proto-oncogene, AP-1 transcription factor subunit (cJUN)
Publikováno v:
Journal of Biological Chemistry. 294:2407-2421
Hyperglycemia and insulin resistance accelerate atherosclerosis by an unclear mechanism. The two factors down-regulate insulin receptor substrate-1 (IRS-1), an intermediary of the insulin/IGF-I signaling system. We previously reported that IRS-1 down
Autor:
Que Zhang, Rui Cai, Yingqian Wang, Gongshe Yang, Naren Qimuge, Weijun Pang, Guorong Tang, Taiyong Yu, Yunmei Sun, Wuzi Dong, Xiaochang Chen, Meilin Ma
Publikováno v:
Journal of Biological Chemistry. 293:19177-19190
MicroRNAs (miRNAs) are noncoding RNAs that regulate gene expression at the post-transcriptional level and are involved in the regulation of the formation, maintenance, and function of skeletal muscle. Using miRNA sequencing and bioinformatics analysi
Publikováno v:
Journal of Biological Chemistry. 293:14371-14383
Signaling proteins, including bone morphogenetic proteins (BMPs), specifically interact with heparan sulfate (HS). These interactions regulate protein distribution and function and are largely mediated by domains rich in basic amino acids. The N-term
Autor:
Junichiro Takaya, Itaru Imayoshi, Hiromi Shimojo, Ryoichiro Kageyama, Mihoko Takenoya, Naasson Mbambi Mbenza, Yuzo Kodama, Jun Iwata, Kumiko Kobayashi, Motonari Uesugi, Amélie Perron, Yoshihiro Nishikawa
Publikováno v:
Journal of Biological Chemistry. 293:8285-8294
The transcription factor Hes family basic helix-loop-helix transcription factor 1 (Hes1) is a downstream effector of Notch signaling and plays a crucial role in orchestrating developmental processes during the embryonic stage. However, its aberrant s
Autor:
Kamran Melikov, Evgenia Leikina, Vardit Kram, Claudia Gebert, Leonid V. Chernomordik, Santosh Kumar Verma, Berna Uygur, Marian F. Young
Publikováno v:
Journal of Biological Chemistry. 293:254-270
Bone-resorbing multinucleated osteoclasts that play a central role in the maintenance and repair of our bones are formed from bone marrow myeloid progenitor cells by a complex differentiation process that culminates in fusion of mononuclear osteoclas
Autor:
Lunhua Liu, Mustafa Akkoyunlu
Publikováno v:
The Journal of Biological Chemistry
Systemic lupus erythematosus (SLE) is a progressive autoimmune disease characterized by high levels of antibodies directed against nuclear antigens. Elevated serum CD138, a heparan sulfate–bearing proteoglycan, correlates with increased disease act