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Autor:
Takatsugu Miyazaki, Enoch Y. Park
Publikováno v:
J Biol Chem
The domestic silkworm Bombyx mori expresses two sucrose-hydrolyzing enzymes, BmSUH and BmSUC1, belonging to glycoside hydrolase family 13 subfamily 17 (GH13_17) and GH32, respectively. BmSUH has little activity on maltooligosaccharides, whereas other
Publikováno v:
J Biol Chem
Small-molecule inhibitors of insect chitinases have potential applications for controlling insect pests. Insect group II chitinase (ChtII) is the most important chitinase in insects and functions throughout all developmental stages. However, the poss
Autor:
Stephanie Merrigan, Orla Galvin, Anita Sjölander, Claire Kilty, Clare T. Butler, Nora Waghorne, Vickie H. Y. Wong, Breandán N. Kennedy, Carmel M. McVicar, Andrew Smith, Alison L. Reynolds, Temitope Sasore, Gleb Grebnev, Alan W. Stitt, Janina Osman, Yolanda Alvarez
Publikováno v:
Journal of Biological Chemistry. 291:7242-7255
Retinal angiogenesis is tightly regulated to meet oxygenation and nutritional requirements. In diseases such as proliferative diabetic retinopathy and neovascular age-related macular degeneration, uncontrolled angiogenesis can lead to blindness. Our
Autor:
Jared L. Delahaye, Pamela A. Zobel-Thropp, Greta J. Binford, Matthew H. J. Cordes, Sue A. Roberts, Vahe Bandarian, Daniel M. Lajoie
Publikováno v:
Journal of Biological Chemistry. 290:10994-11007
Venoms of the sicariid spiders contain phospholipase D enzyme toxins that can cause severe dermonecrosis and even death in humans. These enzymes convert sphingolipid and lysolipid substrates to cyclic phosphates by activating a hydroxyl nucleophile p
Autor:
Mitsuhiro Ueda, Shoko Shinya, Taro Tamada, Kazutaka Miyatake, Masami Nakazawa, Noriko Kawamoto, Tamo Fukamizo, Takao Arimori, Nobuo Okazaki
Publikováno v:
Journal of Biological Chemistry. 288:18696-18706
Chitinase C from Ralstonia sp. A-471 (Ra-ChiC) has a catalytic domain sequence similar to goose-type (G-type) lysozymes and, unlike other chitinases, belongs to glycohydrolase (GH) family 23. Using NMR spectroscopy, however, Ra-ChiC was found to inte
Autor:
Keith K. Khoo, Mingyu Ye, Matthew A. Perugini, Chengwu Chi, Xiao-Xia Shao, Mi Zhou, Charles A. Galea, Shaoqiong Xu, Raymond S. Norton, Chunguang Wang, Nonlawat Boonyalai
Publikováno v:
Journal of Biological Chemistry. 287:14973-14983
Cone snail venoms are a rich source of peptides, many of which are potent and selective modulators of ion channels and receptors. Here we report the isolation and characterization of two novel conotoxins from the venom of Conus imperialis. These two
Autor:
David Reverter, Giovanni Covaleda, María A. Chávez, Francesc X. Avilés, Maday Alonso del Rivero
Publikováno v:
Journal of Biological Chemistry; Vol 287
NvCI is a novel exogenous proteinaceous inhibitor of metallocarboxypeptidases from the marine snail Nerita versicolor. The complex between human carboxypeptidase A4 and NvCI has been crystallized and determined at 1.7 Å resolution. The NvCI structur
Publikováno v:
Journal of Biological Chemistry. 285:33898-33905
Kv2.1 channels, which are expressed in brain, heart, pancreas, and other organs and tissues, are important targets for drug design. Flecainide and propafenone are known to block Kv2.1 channels more potently than other Kv channels. Here, we sought to
Autor:
Matthew J. Cuneo, Lars C. Pedersen, Anna Pomés, Lori L. Edwards, Joseph M. Krahn, Jill Glesner, Rajendrakumar A. Gosavi, Robert E. London, Martin D. Chapman, Geoffrey A. Mueller
Publikováno v:
Journal of Biological Chemistry. 285:25394-25401
Group 5 allergens from house dust mites elicit strong IgE antibody binding in mite-allergic patients. The structure of Der p 5 was determined by x-ray crystallography to better understand the IgE epitopes, to investigate the biologic function in mite
Autor:
J. Sivaraman, R. Manjunatha Kini, Dieter D’hoedt, Amrita Roy, Selvanayagam Nirthanan, Daniel Bertrand, Nandhakishore Rajagopalan, Xingding Zhou, Ming Zhi Chong, Chun Shin Foo
Publikováno v:
Journal of Biological Chemistry. 285:8302-8315
Snake venoms are a mixture of pharmacologically active proteins and polypeptides that have led to the development of molecular probes and therapeutic agents. Here, we describe the structural and functional characterization of a novel neurotoxin, hadi