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Autor:
Takatsugu Miyazaki, Enoch Y. Park
Publikováno v:
J Biol Chem
The domestic silkworm Bombyx mori expresses two sucrose-hydrolyzing enzymes, BmSUH and BmSUC1, belonging to glycoside hydrolase family 13 subfamily 17 (GH13_17) and GH32, respectively. BmSUH has little activity on maltooligosaccharides, whereas other
Publikováno v:
J Biol Chem
Small-molecule inhibitors of insect chitinases have potential applications for controlling insect pests. Insect group II chitinase (ChtII) is the most important chitinase in insects and functions throughout all developmental stages. However, the poss
Autor:
J. Sivaraman, R. Manjunatha Kini, Dieter D’hoedt, Amrita Roy, Selvanayagam Nirthanan, Daniel Bertrand, Nandhakishore Rajagopalan, Xingding Zhou, Ming Zhi Chong, Chun Shin Foo
Publikováno v:
Journal of Biological Chemistry. 285:8302-8315
Snake venoms are a mixture of pharmacologically active proteins and polypeptides that have led to the development of molecular probes and therapeutic agents. Here, we describe the structural and functional characterization of a novel neurotoxin, hadi
Publikováno v:
Journal of Biological Chemistry. 281:13762-13776
In eukaryotes, dihydropyrimidinase catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Here we describe the three-dimensional structures of dihydropyrimidinase from two euka
Autor:
Michael Lazarus, Kouji Inaka, Takashi Inui, Tsuyoshi Inoue, Zakayi Kabututu, Kubata Bruno Kilunga, Michael Duszenko, Yasushi Kai, Samuel K. Martin, Shigeru Sugiyama, Hiroyoshi Matsumura, Yoshihiro Urade, Yousuke Okano, Yukiko Kusakari, Yuichi Sumii
Publikováno v:
Journal of Biological Chemistry. 280:26371-26382
Trypanosoma brucei prostaglandin F2alpha synthase is an aldo-ketoreductase that catalyzes the reduction of prostaglandin H2 to PGF2alpha in addition to that of 9,10-phenanthrenequinone. We report the crystal structure of TbPGFS.NADP+.citrate at 2.1 a
Autor:
Christine Ebel, Steven J.D. Karlish, Marc le Maire, Rivka Goldshleger, Daniel M. Tal, Alla Shainskaya, Eytan Cohen
Publikováno v:
Journal of Biological Chemistry. 280:16610-16618
Na+,K+-ATPase (porcine alpha/his10-beta) has been expressed in Pichia Pastoris, solubilized in n-dodecyl-beta-maltoside and purified to 70-80% purity by nickel-nitrilotriacetic acid chromatography combined with size exclusion chromatography. The reco
Autor:
Kenwyn R. Gayler, S. Buyya, James D. Swarbrick, D. Gunawardana, Paul R. Gooley, Alexander G. McLennan
Publikováno v:
Journal of Biological Chemistry. 280:8471-8481
Asymmetric diadenosine 5',5'''-P(1),P(4)-tetraphosphate (Ap(4)A) hydrolases play a major role in maintaining homeostasis by cleaving the metabolite diadenosine tetraphosphate (Ap(4)A) back into ATP and AMP. The NMR solution structures of the 17-kDa h
Autor:
Jeremy H. Lakey, Vesna Hojnik, Gregor Anderluh, Juan Manuel González-Mañas, Gregor Gunčar, Zdravko Podlesek, Dušan Turk, Peter Maček, Katarina Kristan, Ion Gutiérrez-Aguirre
Publikováno v:
Journal of Biological Chemistry. 279:46509-46517
Actinoporins are eukaryotic pore-forming proteins that create 2-nm pores in natural and model lipid membranes by the self-association of four monomers. The regions that undergo conformational change and form part of the transmembrane pore are current
Publikováno v:
Journal of Biological Chemistry
Human UMP/CMP kinase plays a crucial role in supplying precursors for nucleic acid synthesis by catalyzing the conversion of UMP, CMP, and dCMP into their diphosphate form. In addition, this kinase is an essential component of the activation cascade
Autor:
Barbara C. Furie, Bruce Furie, Johan Stenflo, Karin M Hansson, Marianne A. Grant, Alan C. Rigby
Publikováno v:
Journal of Biological Chemistry. 279:32464-32473
Glacontryphan-M, a novel calcium-dependent inhibitor of L-type voltage-gated Ca(2+) channels expressed in mouse pancreatic beta-cells, was recently isolated from the venom of the cone snail Conus marmoreus (Hansson, K., Ma, X., Eliasson, L., Czerwiec