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Autor:
Mariëlle C. Haks, Timo Oosenbrug, Maaike E. Ressing, Michel J. van de Graaff, Sander I. van Kasteren
Publikováno v:
Journal of Biological Chemistry
J Biol Chem
Journal of Biological Chemistry, 295, 14325-14342
Journal of Biological Chemistry, 295(42), 14325-14342. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
J Biol Chem
Journal of Biological Chemistry, 295, 14325-14342
Journal of Biological Chemistry, 295(42), 14325-14342. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Surface-exposed Toll-like receptors (TLRs) such as TLR2 and TLR4 survey the extracellular environment for pathogens. TLR activation initiates the production of various cytokines and chemokines, including type I interferons (IFN-I). Downstream of TLR4
Autor:
Eun-Woo Lee, Kyoung Jin Oh, Bonsu Ku, Kwang-Hee Bae, Baek Soo Han, Won Kon Kim, Jeong Su Byun, Seonha Lee, Jung-Eun Gil, Sang Chul Lee, Yeajin Mo, Mihee Oh
Publikováno v:
J Biol Chem
Astrocytes perform multiple essential functions in the developing and mature brain, including regulation of synapse formation, control of neurotransmitter release and uptake, and maintenance of extracellular ion balance. As a result, astrocytes have
Autor:
Nobuhisa Iwata, Naoki Yahata, Motoi Kanagawa, Tsuneyoshi Seki, Hisatomo Kowa, Kei Maruyama, Kazuhiro Kobayashi, Haruhisa Inoue, Tatsushi Toda
Publikováno v:
The Journal of Biological Chemistry
Alzheimer's disease (AD) is the most common type of dementia, and its pathogenesis is associated with accumulation of β-amyloid (Aβ) peptides. Aβ is produced from amyloid precursor protein (APP) that is sequentially cleaved by β- and γ-secretase
Publikováno v:
J Biol Chem
Peroxisome proliferator-activated receptor γ (PPARγ) is the central regulator of adipogenesis, and its dysregulation is linked to obesity and metabolic diseases. Identification of the factors that regulate PPARγ expression and activity is therefor
Autor:
Rodrigo A. Grandy, Loukia Yiangou, Daniel Ortmann, Ludovic Vallier, Anna Osnato, Sanjay Sinha
Publikováno v:
Journal of Biological Chemistry
The Journal of Biological Chemistry
The Journal of Biological Chemistry
The mesoderm is one of the three germ layers produced during gastrulation from which muscle, bones, kidneys, and the cardiovascular system originate. Understanding the mechanisms that control mesoderm specification could inform many applications, inc
Autor:
Minghui Gao, Tianyu Wang, Shaoyang Zhao, Yuchan Mai, Xiaofen Zhong, Bing Long, Baoqiang Kang, Jiaming Gu, Dongwei Li, Jiekai Chen, Chuman Wu, Zechuan Liang, Qing Wang, Junwei Wang, Tian Zhang, Xiao Zhang, Yuhang Li, Yanqi Zhang, Guangjin Pan, Xiaodong Shu, Pengtao Wang, Yongli Shan, Baojian Liao, Jinfu Nie, Lin Guo, Qianyu Chen, Fang Wu, Ke Huang, Yanling Zhu, Jinbing Li, Duanqing Pei, Shuquan Su
Publikováno v:
J Biol Chem
Hematopoietic stem cells (HSCs)/progenitor cells (HPCs) are generated from hemogenic endothelial cells (HECs) during the endothelial-to-hematopoietic transition (EHT); however, the underlying mechanism remains poorly understood. Here, using an array
Autor:
David Kim, Mourad Ogbi, Yao Liang Tang, Ha Won Kim, Neal L. Weintraub, Abdalrahman Zarzour, David W. Stepp, Tyler W. Benson, Xin Yun Lu, Weiqin Chen, Samah Ahmadieh, Brandee Goo, Renee Hilton, Charlotte Greenway, Vijay Patel, David Y. Hui, Nicole K.H. Yiew
Publikováno v:
J Biol Chem
Enhancer of zeste homolog 2 (EZH2), an epigenetic regulator that plays a key role in cell differentiation and oncogenesis, was reported to promote adipogenic differentiation in vitro by catalyzing trimethylation of histone 3 lysine 27. However, inhib
Publikováno v:
J Biol Chem
The transcriptional cofactor nascent polypeptide-associated complex and co-regulator α (NACA) regulates osteoblast maturation and activity. NACA functions, at least in part, by binding to Jun proto-oncogene, AP-1 transcription factor subunit (cJUN)
Publikováno v:
Journal of Biological Chemistry. 294:2407-2421
Hyperglycemia and insulin resistance accelerate atherosclerosis by an unclear mechanism. The two factors down-regulate insulin receptor substrate-1 (IRS-1), an intermediary of the insulin/IGF-I signaling system. We previously reported that IRS-1 down
Autor:
Que Zhang, Rui Cai, Yingqian Wang, Gongshe Yang, Naren Qimuge, Weijun Pang, Guorong Tang, Taiyong Yu, Yunmei Sun, Wuzi Dong, Xiaochang Chen, Meilin Ma
Publikováno v:
Journal of Biological Chemistry. 293:19177-19190
MicroRNAs (miRNAs) are noncoding RNAs that regulate gene expression at the post-transcriptional level and are involved in the regulation of the formation, maintenance, and function of skeletal muscle. Using miRNA sequencing and bioinformatics analysi