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Autor:
Natalya V. Anufrieva, Elena A. Morozova, Olga S. Fedorova, Nikita A. Kuznetsov, S.V. Revtovich, Alexandra A. Kuznetsova, Alexei Nikulin, Nicolai G. Faleev, Tatyana V. Demidkina
Publikováno v:
Journal of Biological Chemistry. 290:671-681
Methionine γ-lyase (MGL) catalyzes the γ-elimination of l-methionine and its derivatives as well as the β-elimination of l-cysteine and its analogs. These reactions yield α-keto acids and thiols. The mechanism of chemical conversion of amino acid
Autor:
Evelyne Deery, Simon J. Moore, Stephen E. J. Rigby, Rebekka Biedendieck, Andy Lawrence, Mark J. Howard, Martin J. Warren
Publikováno v:
Journal of Biological Chemistry. 288:297-305
The anaerobic pathway for the biosynthesis of cobalamin (vitamin B(12)) has remained poorly characterized because of the sensitivity of the pathway intermediates to oxygen and the low activity of enzymes. One of the major bottlenecks in the anaerobic
Autor:
David H. Sherman, Daniel Oves-Costales, Youngchang Kim, Shandee D. Dixon, Gregory L. Challis, Andrzej Joachimiak, William H. Eschenfeldt, Michael M. Schofield, Brian F. Pfleger, Natalia Maltseva, Tyler D. Nusca, Philip C. Hanna, Lucy Stols, Jung Yeop Lee, Jamie B. Scaglione
Publikováno v:
Journal of Biological Chemistry. 287:16058-16072
Petrobactin, a mixed catechol-carboxylate siderophore, is required for full virulence of Bacillus anthracis, the causative agent of anthrax. The asbABCDEF operon encodes the biosynthetic machinery for this secondary metabolite. Here, we show that the
Publikováno v:
Journal of Biological Chemistry. 286:29428-29439
The homocitrate synthase from Thermus thermophilus (TtHCS) is a metal-activated enzyme with either Mg(2+) or Mn(2+) capable of serving as the divalent cation. The enzyme exhibits a sequential kinetic mechanism. The mechanism is steady state ordered w
Publikováno v:
Journal of Biological Chemistry. 285:41412-41421
Resorcylic acid lactones are fungal polyketides that display diverse biological activities, with the potent Hsp90 inhibitor radicicol being an important representative member. Two fungal iterative polyketide synthases (IPKSs), Rdc5, the highly reduci
Autor:
Yanling Yang, Stanislav Pospisil, František Škanta, Miroslav Petříček, Shih-Feng Tsai, Heinz G. Floss, Zhe Rui, Chung-Yung Chen, Tin-Wein Yu, Kateřina Petříčková
Publikováno v:
Journal of Biological Chemistry. 285:24915-24924
Asukamycin, a member of the manumycin family metabolites, is an antimicrobial and potential antitumor agent isolated from Streptomyces nodosus subsp. asukaensis. The entire asukamycin biosynthetic gene cluster was cloned, assembled, and expressed het
Autor:
Sergei A. Dikanov, Robert B. Gennis, Sophia M. Yi, Kuppala V. Narasimhulu, Rimma I. Samoilova
Publikováno v:
Journal of Biological Chemistry. 285:18241-18251
Cytochrome aa(3)-600 is one of the principle respiratory oxidases from Bacillus subtilis and is a member of the heme-copper superfamily of oxygen reductases. This enzyme catalyzes the two-electron oxidation of menaquinol and the four-electron reducti
Autor:
Pietro Roversi, Susan M. Lea, K.J. Leath, Robin Antrobus, Ben C. Berks, Véronique Sauvé, Elspeth F. Garman
Publikováno v:
Journal of Biological Chemistry. 284:21707-21718
SoxB is an essential component of the bacterial Sox sulfur oxidation pathway. SoxB contains a di-manganese(II) site and is proposed to catalyze the release of sulfate from a protein-bound cysteine S-thiosulfonate. A direct assay for SoxB activity is
Publikováno v:
Journal of Biological Chemistry. 284:21856-21862
Thermotoga maritima is a Gram-negative, hyperthermophilic bacterium whose peptidoglycan contains comparable amounts of L- and D-lysine. We have determined the fine structure of this cell-wall polymer. The muropeptides resulting from the digestion of
Publikováno v:
Journal of Biological Chemistry. 284:11160-11170
Curcuminoids found in the rhizome of turmeric, Curcuma longa, possess various biological activities. Despite much attention regarding the biosynthesis of curcuminoids because of their pharmaceutically important properties and biosynthetically intrigu