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Publikováno v:
Journal of Basic and Clinical Physiology and Pharmacology. 30:131-137
Background Development of drug-induced hepatic damage (DIHD) during chemotherapy is the most common reason for interruption in chemotherapy. This study evaluated the hepatoprotective activity of the ethanolic extract of Tamarindus indica stem bark (E
Publikováno v:
Journal of Basic and Clinical Physiology and Pharmacology. 30
Background Osteoarthritis (OA) is a chronic disease in the joints. One of the proinflammatory cytokines that is thought to have a major role in the inflammatory process, the emergence of pain, and cartilage damage in OA is tumor necrosis factor α (T
Autor:
Temitayo Olabisi Ajibade, Temiday O Omóbòwálé, Ebunoluwa Racheal Asenuga, Gana James, Momoh A. Yakubu, Olumuyiwa Abiola Adejumobi, Ademola Adetokunbo Oyagbemi, Orotusin Oyetola, Olufunke Eunice Ola-Davies, Adeolu Alex Adedapo, Ayorinde Mobolanle Folasire
Publikováno v:
Journal of Basic and Clinical Physiology and Pharmacology. 29:19-27
Background:The use of doxorubicin (DOX) as an antineoplastic agent has been greatly limited because of the myriad of toxic sequelae associated with it. The aim of this study was to assess the protective effects of gallic acid (GA) on DOX-induced card
Publikováno v:
Journal of basic and clinical physiology and pharmacology. 30(1)
BackgroundThe negative impact of diabetes on the liver is well documented. The white butterfly (Clerodendrum volubile) leaf has been used in traditional practices for the treatment of various diseases, such as hypertension, diabetes, and rheumatism,
Publikováno v:
Journal of basic and clinical physiology and pharmacology. 30(1)
Background The aim of this study is to investigate the effects of pravastatin (PS) against doxorubicin (DOX)-induced testicular toxicity. Methods A total of 24 healthy male Sprague-Dawley rats were equally divided into four groups. Group I received n
Autor:
Iraj Khodadadi, Heidar Tavilani, Nejat Kheiripour, Mohammad Hashemnia, Mohammad Taghi Goodarzi, Jamshid Karimi
Publikováno v:
Journal of basic and clinical physiology and pharmacology. 29(3)
Background:In this study, we have investigated whether silymarin intake influences lipid and glycogen content in conjunction with sirtuin1 (SIRT1) and sterol regulatory element-binding protein 1c (SREBP-1c) expressions in liver of type 2 diabetic rat
Autor:
Arturo Alejandro Dreifuss, Aleksander Roberto Zampronio, Daniel Fraga, Amanda Leite Bastos-Pereira
Publikováno v:
Journal of Basic and Clinical Physiology and Pharmacology. 28
Background Zymosan is a fungal cell wall protein-carbohydrate complex that is known to activate inflammatory pathways through the Toll-like receptors and is commonly used to induce fever. Nevertheless, the central mediators that are involved in the z
The ameliorating effect of Centella asiatica ethanolic extract on albino rats treated with isoniazid
Publikováno v:
Journal of basic and clinical physiology and pharmacology. 28(1)
Background:Isoniazid, also called isonicotinyl hydrazine (INH), is a commonly used drug for treating tuberculosis. The main drawback is its toxic side effects.Methods:The adverse effects induced by INH (50 mg/kg bw) administration on haematological p
Publikováno v:
Journal of Basic and Clinical Physiology and Pharmacology. 26
Background Growing evidences indicate that endogenous oxidants and antioxidant defense interact in a vicious cycle, which plays a critical role in the pathogenesis of cognitive dysfunction. In this study, we examined the effect of N-acetyl cysteine (
Autor:
Babatunde Adekunle Murtala, Hussein Mofomosara Salahdeen, A R A Alada, OK Yemitan, Gbolahan O Idowu
Publikováno v:
Journal of basic and clinical physiology and pharmacology. 26(2)
BACKGROUND The effect of Tridax procumbens aqueous ethanolic extract on the rat corpus cavernosum smooth muscles was evaluated in the present study. METHOD Corpus cavernosum strips obtained from healthy, young, adult male Wistar albino rats (250-300