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Publikováno v:
Journal of Applied Toxicology. 29:483-488
Oxime reactivators HI-6, obidoxime, trimedoxime, K347 and K628 were investigated as drugs designed for treatment of tabun intoxication. The experiments were performed on rats in order to simulate real conditions. Rats were intoxicated with one LD50 o
Publikováno v:
Journal of Applied Toxicology. 29:356-363
To evaluate new drugs' potential for hepatosteatosis, we developed a cell-based assay using a fluorescent fatty acid analog: BODIPY558/568 C12. Rat primary hepatocytes were exposed to positive reference compounds [cyclosporine A (CsA), clofibrate (CF
Autor:
Joseph P. Hanig, Richard D. Beger, Laura K. Schnackenberg, Jun Zhang, Parvaneh Espandiari, Terry J. Miller, Eugene H. Herman, Alan Knapton
Publikováno v:
Journal of Applied Toxicology. 28:628-637
A multi-age rat model was evaluated as a means to identify a potential age-related difference in liver injury following exposure to valproic acid (VPA), a known pediatric hepatotoxic agent. Different age groups of Sprague-Dawley (SD) rats (10-, 25-,
Publikováno v:
Journal of Applied Toxicology. 28:271-282
Adriamycin is an effective anthracycline anti-tumor antibiotic. However, the clinical use of adriamycin has been restricted by its serious side effects. Some reports indicated that the side effects of adriamycin could cause systemic injury, in which
Autor:
Maria de Lourdes Pires Bianchi, Nádia Maria Martins, Neife Aparecida Guinaim dos Santos, Antonio Cardozo dos Santos, Carlos Curti
Publikováno v:
Journal of Applied Toxicology. 28:337-344
Cisplatin is a potent and widely used chemotherapeutic agent. Nephrotoxicity induced by this drug has been well documented. However, very little information is available on cisplatin-induced hepatotoxicity and its underlying mechanism remains unclear
Autor:
George A. Petroianu, Dietrich E. Lorke, Abdu Adem, Huba Kalász, Syed M. Nurulain, R. Sheen, Mohammed Y. Hasan
Publikováno v:
Journal of Applied Toxicology. 27:350-357
Clinical experience with oximes, cholinesterase reactivators used in organophosphorus poisoning, has been disappointing. Their major anatomic site of therapeutic action and their ability to pass the blood-brain barrier (BBB) are controversial. Althou
Publikováno v:
Journal of Applied Toxicology. 26:262-268
Oximes are cholinesterase reactivators used in organophosphorus poisoning. Clinical experience with pralidoxime (PRX) and other oximes is disappointing and their routine use has been questioned. In addition it is known that not all oximes are equally
Publikováno v:
Journal of Applied Toxicology. 25:153-165
The role of cytochrome P450 activity in the nephrotoxicity of chlorotrifluoroethylene (CTFE) and 1,1-dichloro-2,2-difluoroethylene (DCDFE) was investigated in the male rat. Hepatic cytochrome P450 1A1 and principally P450 2B1[sol ]2 were induced by
Publikováno v:
Journal of Applied Toxicology. 25:296-300
In our study, we have tested six acetylcholinesterase (AChE) reactivators (pralidoxime, obidoxime, HI-6, trimedoxime, BI-6 and Hlö-7) for reactivation of sarin- and cyclosarin-inhibited AChE using an in vitro reactivation test. We have used rat brai
Publikováno v:
Journal of Applied Toxicology. 24:257-260
The benzamide compound metoclopramide (MCP) protects against cholinesterase inhibition by paraoxon (POX) both in vitro and in vivo. This study evaluates MCP-conferred protection of enzyme activity head to head against the therapeutic gold standard pr