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pro vyhledávání: ''
Autor:
Theodore A. Omachi, L. Islam, Claus Bachert, Rui Zhu, Philippe Gevaert, Jonathan Corren, Monica Ligueros-Saylan, Joseph K. Han, Joaquim Mullol, Kit Wong, Ryan Owen, Derrick Kaufman, Monet Howard, Stella E. Lee
Publikováno v:
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by IgE hyperproduction and eosinophilic inflammation. The anti-IgE antibody, omalizumab, has demonstrated efficacy in patients with CRSwNP and comorbid asthma previously.
Autor:
Joaquim Mullol, Joseph K. Han, Rui Zhao, Kit Wong, Randall A. Ow, Monet Howard, L. Islam, Claus Bachert, Monica Ligueros-Saylan, Theodore A. Omachi, Stella E. Lee, Jonathan Corren, R. Saenz, Philippe Gevaert
Publikováno v:
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) frequently remains uncontrolled despite maximal medical therapy and sinonasal surgery, presenting several unmet needs and challenges. Omalizumab previously demonstrated efficacy in CRSwNP
Autor:
René Zieglmayer, Friedrich Horak, Albert S. Yu, Kamal D. Puri, Guan Xing, Leanne Holes, Bart H. Steiner, Petra Zieglmayer, Patrick Lemell
Publikováno v:
Journal of Allergy and Clinical Immunology. 137:1733-1741
Phosphatidylinositol 3-kinase p110δ isoform (PI3K p110δ) activity is essential for mast cell activation, suggesting that inhibition of PI3K p110δ might be useful in treating allergic diseases.We sought to determine the effect of the PI3K p110δ-se
Timing and duration of omalizumab response in patients with chronic idiopathic/spontaneous urticaria
Autor:
Sam Khalil, Jonathan A. Bernstein, Karin Rosén, Marta Ferrer, Karina Raimundo, Benjamin Trzaskoma, Theodore A. Omachi, Evgeniya Antonova, James L. Zazzali, Allen P. Kaplan
Publikováno v:
Journal of Allergy and Clinical Immunology. 137(2):474-481
Background Few data are available that describe response patterns in patients with chronic idiopathic urticaria (CIU)/chronic spontaneous urticaria (CSU) treated with omalizumab. Objective We sought to describe response patterns by using data from th
Autor:
Dirk Esser, Costel Chirila, Petra Moroni-Zentgraf, Eric D. Bateman, Andy Fowler, Maria Fernandez, J. Mark FitzGerald
Publikováno v:
Journal of Allergy and Clinical Immunology. 136(4):914-922
Background The Asthma Quality of Life Questionnaire (AQLQ) and the Asthma Control Questionnaire (ACQ) are widely used in asthma research; however, in studies of newer asthma treatments, mean improvements in these measures compared with placebo arms d
Autor:
Stephen Pawsey, Charles W. Frankish, Roderick Peter Hafner, Kristen Armstrong, Mark W. Tenn, Anne K. Ellis, Lisa M. Steacy
Publikováno v:
Journal of Allergy and Clinical Immunology. 145:610-618.e9
Grass allergen peptides are in development for the treatment of grass pollen-induced allergic rhinoconjunctivitis. A previous randomized, placebo-controlled study demonstrated that grass allergen peptides significantly improved total rhinoconjunctivi
Autor:
James G. Krueger, Howard Sofen, Cesar Calderon, Carrie Brodmerkel, Y. Wasfi, Robert Matheson, Philippe Szapary, Kim Campbell, Stacy Smith, Stanley J. Marciniak, Y. Wang, Craig L. Leonardi, Katherine Li
Publikováno v:
Journal of Allergy and Clinical Immunology. 133:1032-1040
Background IL-23 expression is increased in psoriatic lesions and might regulate T H 17 T-cell counts in patients with psoriasis. Objectives We sought to test a novel IL-23–specific therapeutic agent for the treatment of psoriasis. Methods In this
Autor:
Olivier de Beaumont, Hans-Jørgen Malling, Friedrich Horak, Alain Didier, Margitta Worm, Michel Melac, Gordon Sussman, Martine Le Gall
Publikováno v:
Journal of Allergy and Clinical Immunology. 128:559-566
Seasonal allergic rhinoconjunctivitis affects millions of persons. The efficacy of allergen sublingual immunotherapy (SLIT) was demonstrated in previous short-term studies.We sought to evaluate the sustained efficacy of 2 dosing regimens of a pre- an
Publikováno v:
Journal of Allergy and Clinical Immunology. 128:348-352
WOS: 000293280800015 PubMed: 21624649 Background: The place of systemic corticosteroids in the treatment of children with chronic rhinosinusitis (CRS) remains unclear. Objective: We sought to assess the effectiveness and tolerability of oral methylpr
Autor:
Juan C. Celedón, Scott T. Weiss, Robert C. Strunk, Benjamin A. Raby, Robyn T. Cohen, Kristel Van Steen, Bernard Rosner, Anne L. Fuhlbrigge, Robert S. Zeiger
Publikováno v:
Journal of Allergy and Clinical Immunology. 126:491-497
Background Few studies have examined the effects of in utero smoke exposure (IUS) on lung function in children with asthma, and there are no published data on the impact of IUS on treatment outcomes in children with asthma. Objectives To explore whet