Zobrazeno 1 - 10
of 7 591
pro vyhledávání: '"RC254-282"'
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)
Externí odkaz:
https://doaj.org/article/b38593368288459baa615bd47c7aead0
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)
Background While anti-programmed cell death protein-1 (PD-1) monotherapy has shown effectiveness in treating lung cancer, its response rate is limited to approximately 20%. Recent research suggests that abnormal lipid metabolism in patients with lung
Externí odkaz:
https://doaj.org/article/07c404bd77a74d24a649c8299feecb07
Autor:
Renee N Donahue, Jeffrey Schlom, James L Gulley, James W Hodge, Claudia Palena, Duane H Hamilton, Sofia R Gameiro
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)
The development of vaccines, especially RNA-based, directed against patient-specific tumor neoepitopes is an active and productive area of cancer immunotherapy. Promising clinical results in melanoma and other solid tumor types are emerging. As with
Externí odkaz:
https://doaj.org/article/a0dfb2ad06104e178521dabe0f22daa7
Autor:
Saraí G De León-Rodríguez, Cristina Aguilar-Flores, Julián A Gajón, Ángel Juárez-Flores, Alejandra Mantilla, Raquel Gerson-Cwilich, José Fabián Martínez-Herrera, Diana Alejandra Villegas-Osorno, Claudia T Gutiérrez-Quiroz, Sergio Buenaventura-Cisneros, Mario Alberto Sánchez-Prieto, Edmundo Castelán-Maldonado, Samuel Rivera Rivera, Ezequiel M Fuentes-Pananá, Laura C Bonifaz
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)
Background Melanoma, the most lethal form of skin cancer, has undergone a transformative treatment shift with the advent of checkpoint blockade immunotherapy (CBI). Understanding the intricate network of immune cells infiltrating the tumor and orches
Externí odkaz:
https://doaj.org/article/8ab5aa2af15e4a039c6dff460d7a7344
Autor:
Reinhard Dummer, Joanna Mangana, Egle Ramelyte, Achim Weber, Elias Burri, Phil F Cheng, Alia Schneider
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)
Background Immune-related hepatitis (irHepatitis) is a relatively common immune-related adverse event (irAE) of checkpoint inhibitors. Often, it responds well to steroids; however, in refractory cases, further therapy is needed. Anti-tumor necrosis f
Externí odkaz:
https://doaj.org/article/0b1abeb1e951483198d0d10279a0fc65
Autor:
Douglas B Johnson, Kylie Fletcher
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)
Immune checkpoint inhibitors (ICIs) have transformed cancer treatment, improving outcomes for many patients. However, toxicities termed immune-related adverse events (irAEs) are limitations of these revolutionary treatments. These irAEs may resolve w
Externí odkaz:
https://doaj.org/article/71902b4475a548f1b06b7a09efc88722
Autor:
Junping Jing, Laura Bover, C Ian Mockridge, Kerry L Cox, Mark S Cragg, Tatyana Inzhelevskaya, Chris A Penfold, Vikki English, Jane E Willoughby, Hong Shi, Peter J Morley, Heather Jackson, Roopa Srinivasan, Tom Murray, Axel Hoos, Paul Bojczuk, James Smothers, Niranjan Yanamandra, Lang Dou, Sabyasachi Bhattacharya, Laura Seestaller-Wehr, David Kilian, Kui S Voo, Mel John, Heather Niederer, Andrew J Shepherd, Laura Hook, Stephanie Hopley, Sara J Brett, Christopher Hopson, Elaine Paul, Stephen L Martin
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)
Background OX40 has been widely studied as a target for immunotherapy with agonist antibodies taken forward into clinical trials for cancer where they are yet to show substantial efficacy. Here, we investigated potential mechanisms of action of anti-
Externí odkaz:
https://doaj.org/article/1d4a1e220c0f453894379600a08cb4a4
Autor:
Shiran Hoogi, Tilda Barliya, Raphaëlle Toledano Zur, Orna Atar, Ifat Abramovich, Eyal Gottlieb, Noga Ron-Harel, Cyrille J Cohen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)
Background T cells play a central role in the antitumor response. However, they often face numerous hurdles in the tumor microenvironment, including the scarcity of available essential metabolites such as glucose and amino acids. Moreover, cancer cel
Externí odkaz:
https://doaj.org/article/16ec3a00ba5d425897d819d2c3231f34
Autor:
Qi Wang, Bin Jiang, Ming Wu, Ming Chen, Fuxiang Liang, Hong Shen, Pin Wu, Yafei Liu, Chuanqiang Wu, Huan Yu, Xiancong Huang, Zhiling Lou, Zixiang Wu
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)
Background Esophageal cancer (ESCA) is a form of malignant tumor associated with chronic inflammation and immune dysregulation. However, the specific immune status and key mechanisms of immune regulation in this disease require further exploration.Me
Externí odkaz:
https://doaj.org/article/db88ee00577d43e0a3f437ba16403b3b
Autor:
SungHoon Kim, Sang Wun Kim, Su-Hyung Park, Eui-Cheol Shin, Junsik Park, Yong Jae Lee, Jung Yun Lee, Jung Chul Kim
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)
Background We aimed to investigate the distinct immunological characteristics of the tumor immune microenvironment in epithelial ovarian cancer (EOC) according to BRCA1/2 mutations status and differential PD-1 expression levels.Methods Tumor-infiltra
Externí odkaz:
https://doaj.org/article/aca86c33372346979d5a8cb2b1b09e2e