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Autor:
Xing-Jie Liang, Yuri Kotliarov, Peter McL. Black, Patrick Y. Wen, Dragan Maric, Oluwaseun Akeju, Umberto De Girolami, Wells W. Wu, John K. Park, Jean C. Zenklusen, Teri T.B. Ngo, Wei Zhang, Tien Peng, Neal Jeffries, Sandra Pastorino, Rong Fong Shen, Dong Won Kang, Howard A. Fine
Publikováno v:
JNCI Journal of the National Cancer Institute. 99:639-652
Background Malignant gliomas are generally resistant to all conventional therapies. Notable exceptions are anaplastic oligodendrogliomas with loss of heterozygosity on chromosome 1 p (1p +/- ). Patients with 1p +/- anaplastic oligodendroglioma freque
Autor:
Kristin Kee, Peter Kanter, Jean M. Veith, Fernando Cabral, William R. Greco, Amarnath Sharma, Iwao Ojima, Michael R. Vredenburg, Paula Pera, Ralph J. Bernacki
Publikováno v:
JNCI Journal of the National Cancer Institute. 93:1234-1245
Background: The taxane paclitaxel (Taxol) is often of limited efficacy in chemotherapeutic regimens because some cancer cells express high levels of the efflux pump, P-glycoprotein (Pgp), which removes the drug from the cells. The orally active pacli
Autor:
Ingrid B.J.K. Joseph, John T. Isaacs
Publikováno v:
JNCI Journal of the National Cancer Institute. 90:1648-1653
Background. Tumor-associated macrophages (TAMs) can either promote angiogenesis (i.e., the formation of new blood vessels) in tumors by secreting tumor necrosis factor-a (TNF-a )o r inhibit angiogenesis by producing granulocyte‐macrophage colony-st
Autor:
Greg Ripple, Dona Alberti, Chriss Feierabend, Howard H. Bailey, Rhoda Z. Arzoomanian, R. Timothy Mulcahy, Kendra D. Tutsch, Julian C. Schink, George Wilding, Marcia Pomplun, David M. Mahvi
Publikováno v:
JNCI Journal of the National Cancer Institute. 89:1789-1796
Background: Increased intracellular glutathione has long been associated with tumor cell resistance to various cytotoxic agents. An inhibitor of glutathione biosynthesis, L-S,R-buthionine sulfoximine (BSO), has been shown to enhance the cytotoxicity
Publikováno v:
JNCI Journal of the National Cancer Institute. 87:1072-1077
Background : Many critical cellular functions such as mitosis, cell movement, and maintenance of cell structure are performed by microtubules. Antimicrotubule agents (which disrupt or block the formation of microtubules) are among the most widely use
Autor:
Rachel Tsan, Corazon D. Bucana, Isaiah J. Fidler, Robert Radinsky, Dominic Fan, Zhongyun Dong, Christoph Wilmanns
Publikováno v:
JNCI Journal of the National Cancer Institute. 86:913-920
BACKGROUND The major cause of death from cancer is metastases that are resistant to conventional therapies. The resistance of metastatic tumor cells to chemotherapy can be caused by their intrinsic properties, such as increased expression of the mdr
Publikováno v:
JNCI Journal of the National Cancer Institute. 84:1653-1660
Background Studies indicating that verapamil substantially enhances doxorubicin levels in certain drug-resistant tumor cells have led to the use of verapamil in combination with doxorubicin in animal and clinical studies of multidrug-resistant tumors
Publikováno v:
JNCI Journal of the National Cancer Institute. 84:494-500
Background Rhizoxin is a new macrocyclic lactone isolated from the fungus Rhizopus chinensis which displays broad-spectrum antitumor activity against murine and human tumor xenografts and has activity against a number of vincristine-resistant tumors
Autor:
Robert C. Young, N. Carp, Thomas C. Hamilton, Robert L. Comis, Kenneth D. Tew, Robert F. Ozols, K. Padavic, Frank P. LaCreta, Peter J. O'Dwyer
Publikováno v:
JNCI Journal of the National Cancer Institute. 84:264-267
Publikováno v:
JNCI Journal of the National Cancer Institute. 83:24-28
Within three repeated 7-day incubation periods with either methotrexate (MTX) or trimetrexate (TMTX), human colon adenocarcinoma cells (HCT-8) developed high levels of resistance to these drugs, as evidenced by approximately 20- and 50-fold increases