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pro vyhledávání: '"Jane Yuet Ching Hui"'
Metabolic reprogramming augments potency of human pSTAT3-inhibited iTregs to suppress alloreactivity
Autor:
Brian C. Betts, Kelly Walton, Jane Yuet Ching Hui, Michael A. Linden, Meghan Hupp, Colleen L. Forster, Said M. Sebti, John V. Kiluk, Jongphil Kim, Joseph Pidala, David H. McKenna, Harshani R. Lawrence, Jordan Reff, Bruce R. Blazar, John L. Cleveland, Claudio Anasetti, Mario R. Fernandez, Nicholas J. Lawrence, Steven Z. Pavletic, Marie Catherine Lee, Elizabeth M. Sagatys
Publikováno v:
JCI Insight
Immunosuppressive donor Tregs can prevent graft-versus-host disease (GVHD) or solid-organ allograft rejection. We previously demonstrated that inhibiting STAT3 phosphorylation (pSTAT3) augments FOXP3 expression, stabilizing induced Tregs (iTregs). He