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Publikováno v:
Japanese Journal of Clinical Oncology
Background We aimed to evaluate cost-effectiveness of enzalutamide in chemotherapy-naïve metastatic castration-resistant prostate cancer patients in Japan. Methods A Markov model was developed to capture time spent by patients in various health stat
Autor:
Won Seog Kim, Yusuke Sonehara, Hirokazu Nagai, Kensei Tobinai, Youko Suehiro, Naokuni Uike, Toshiki Uchida, Fumiko Nagahama, Michinori Ogura, Kenichi Ishizawa
Publikováno v:
Japanese Journal of Clinical Oncology
Objective Two phase I studies of darinaparsin including Japanese and Korean patients with relapsed/refractory peripheral T-cell lymphoma were performed to evaluate its safety (primary purpose), efficacy and pharmacokinetic profile (ClinicalTrials.gov
Autor:
Rita Humeniuk, Kensei Tobinai, Masato Fukui, Anita Mathias, Tomohiro Kinoshita, Noriko Fukuhara, Kazuhito Yamamoto, Nishan Rajakumaraswamy, Hirokazu Nagai, Koji Izutsu, Guan Xing, Go Yamamoto, Pankaj Bhargava
Publikováno v:
Japanese Journal of Clinical Oncology. 50:1395-1402
Objective Idelalisib is an orally administered, highly selective inhibitor of phosphatidylinositol 3-kinase-δ. In this phase 1b study, the safety, tolerability and pharmacokinetics of idelalisib, an oral inhibitor of phosphatidylinositol 3-kinase-δ
Autor:
Yoshinobu Saito, Masahiko Kusumoto, Yuichiro Ohe, Masafumi Sata, Kei Sakamoto, Terufumi Kato, Toshimitsu Tokimoto, Reiko Tamura, Tomohisa Baba, Akihiko Gemma, Masatoshi Sugeno, Ou Yamaguchi, Wataru Shimizu, Masahiro Endo, Fumikazu Sakai
Publikováno v:
Japanese Journal of Clinical Oncology
Objective Adverse drug reactions (ADRs) during real-world osimertinib use were investigated in Japan. Methods Patients with epidermal growth factor receptor (EGFR) T790M-positive non-small cell lung cancer treated with second-line or later oral osime
Autor:
Nagahiro Saijo, Yoshiyuki Shibasaki, Yutaka Endo, Mototsugu Oya, Akihiko Gemma, Yasuharu Toyoshima, Hideyuki Akaza, Kazuo Sato, Shigeru Sugiyama, Naoto Miyanaga, Taku Uryu
Publikováno v:
Japanese Journal of Clinical Oncology
Objective A prospective, observational, post-marketing surveillance was conducted to assess the safety and effectiveness of temsirolimus in patients with renal cell carcinoma in Japan. Methods Patients prescribed temsirolimus for advanced renal cell
Autor:
Junji Suzuki, Takahito Okuda, Sou Adachi, Takuma Matsunaga, Makoto Ito, Yukihiko Oshima, Yasuo Yoshioka, Kazuhiro Ohtakara, Souichirou Abe, Arisa Takeuchi, Yuuki Takase, Kojiro Suzuki, Hironori Takahashi
Publikováno v:
Japanese journal of clinical oncology. 51(8)
Objective We aimed to report the 2-year results of stereotactic body radiation therapy for prostate cancer and identify the clinical and dosimetric factors that predict acute genitourinary toxicities. Methods We retrospectively reviewed the medical r
Autor:
Taro Shibata, Yuya Sato, Tetsuya Hamaguchi, Dai Shida, Junki Mizusawa, Yukihide Kanemitsu, Kenichi Miyamoto, Atsuo Takashima, Hiroshi Katayama, Haruhiko Fukuda, Yasuhiro Shimada, Kenichi Nakamura
Publikováno v:
Japanese Journal of Clinical Oncology. 49:985-990
Adjuvant chemotherapy is the current standard treatment for stage III colorectal cancer after curative resection. However, the prognosis of stage III colorectal cancer is still poor even after curative resection and adjuvant chemotherapy. Several obs
Autor:
Tadamichi Denda, Kei Muro, Takeharu Yamanaka, Hiroyuki Bando, Toshiki Masuishi, Kenichi Sugihara, Yasuo Ohashi, Michio Itabashi, Hiroki Hashida
Publikováno v:
Japanese Journal of Clinical Oncology
A striking resection rate and survival benefit of first-line cetuximab-containing chemotherapy were demonstrated in patients with mCRC who were classified into the potentially resectable group.
Objective We aimed to clarify the clinical practice
Objective We aimed to clarify the clinical practice
Publikováno v:
Japanese Journal of Clinical Oncology. 49:270-275
Objective While external beam radiotherapy boost has been one of the standard management options for locally advanced cervical cancer that is not treatable with intracavitary brachytherapy, its efficacy remains unclear. We assessed clinical outcomes
Autor:
Satoshi Fukasawa, Hiroyoshi Suzuki, Kazushiro Kawaguchi, Hidehisa Noguchi, Kentaro Enjo, Namphuong Tran, Mary Todd, Karim Fizazi, Nobuaki Matsubara
Publikováno v:
Japanese Journal of Clinical Oncology
Abiraterone acetate plus prednisone in addition to androgen-deprivation therapy (ADT) was efficacious versus ADT alone in Japanese men with metastatic hormone-naïve prostate cancer. No new safety concerns were identified.
Objectives To evaluate
Objectives To evaluate