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Publikováno v:
Japanese Circulation Journal. 61:687-694
This study was undertaken to examine whether a sulthydryl-containing angiotensin-converting enzyme (ACE) inhibitor, captopril, improves postischemic cardiac function and myocardial metabolism in the perfused working rat heart, and to elucidate the me
Autor:
Minoru Yasujima, Masahiro Kamimoto, Masahiro Kohzuki, Tokutaro Sato, Xue Min Wu, Kazunori Yoshida, Keishi Abe, Zhong Li Jiang, Colin I. Johnston, Masayuki Kanazawa
Publikováno v:
Japanese Circulation Journal. 60:972-980
To ascertain the pathophysiological roles of the renin-angiotensin system and endothelin in heart failure and cardiac hypertrophy, we assessed changes in cardiac angiotensin converting enzyme (ACE) and endothelin-1 (ET-1) receptor using rats in which
Autor:
Hideki Sasaki, Atsuya Namiki, Mitsuyuki Shimizu, Kozo Hamaya, Kazuhiko Ogawa, Yukihide Isogai, Tsuneo Mizokami, Toshio Yagi, Haruka Kato, Junko Sanjo
Publikováno v:
Japanese Circulation Journal. 56:1130-1137
It is well known that isoproterenol (ISO) a nonselective beta adrenoceptor agonist induces cardiac hypertrophy. It can be assumed that, in addition to its direct cardiac effect, ISO has a cardiac trophic effect via stimulation of the renin angiotensi
Autor:
Ryuko Matsuda, Kunihiko Teraoka, Saichi Hosoda, Noboru Kaneko, Tatsuro Uchida, Yoshifumi Horikawa
Publikováno v:
Japanese Circulation Journal. 55:1118-1123
Using a modified Langendorff system, we established an experimental model of kinetic cell death in the rat heart. After calcium (5.5 mM) was loaded for 20 min and 10(-7) mol isoproterenol was then delivered to the perfusion medium, the hearts develop
Publikováno v:
Japanese Circulation Journal. 54:89-99
The effects of long-term treatment with diltiazem on the heart in normotensive (WKY) and spontaneously hypertensive rats (SHR) were studied. Diltiazem was added to the drinking fluid (900 mg/liter) and given ad libitum from 19 to 26 weeks of age, whe
Autor:
Iku Toda, Kaname Akioka, Takashi Omura, Masakazu Teragaki, Junichi Yoshikawa, Hiroshi Iwao, Shokei Kim, Kazuhide Takeuchi, Minoru Yoshiyama, Akihisa Hanatani
Publikováno v:
Japanese circulation journal. 62(1)
We examined the effect of a calcium antagonist, manidipine hydrochloride, on cardiac hypertrophy and the expression of the atrial natriuretic peptide (ANP), transforming growth factor beta 1 (TGF-beta 1), and extracellular matrix protein genes in rat
Autor:
Seikou Yasunaga, Tetsunori Saikawa, Mikiko Nakagawa, Hidetoshi Yonemochi, Morio Ito, Toshiie Sakata, Takeshi Takakura, Tetsu Iwao
Publikováno v:
Japanese circulation journal. 61(2)
In patients with congestive heart failure (CHF), β-receptor up-regulation is regarded as one of the mechanisms leading to improved function and prognosis. To clarify whether β-receptor up-regulation is involved in the mechanisms underlying the bene
Autor:
Tomoko Tani, Hiroyuki Yamagishi, Minoru Yoshiyama, Takashi Ohmura, Kaname Akioka, Toshio Nishikimi, Iku Toda, Shiro Yanagi, Kazuhide Takeuchi, Tadanao Takeda, Masakazu Teragaki
Publikováno v:
Japanese circulation journal. 59(11)
We investigated the effect of chronic administration of an angiotensin II type-1 receptor antagonist in the development of heart failure due to volume overload in rats.Aortocaval fistula (AVF), a model of volume overloaded heart failure, was induced
Publikováno v:
Japanese circulation journal. 59(9)
Angiotensin-converting enzyme inhibitors may regress left ventricular hypertrophy (LVH) without decreasing blood pressure (BP). The aim of the present study was to compare the effects of low and high doses of lisinopril and the angiotensin II recepto
Autor:
Shigeki Hirooka, Hideaki Uchino, Minoru Kohi, Masahiko Washio, Kana Fukui, Manabu Fukasawa, Hiroyuki Orita
Publikováno v:
Japanese circulation journal. 58(8)
The purpose of this study was to evaluate the functional and biochemical effects of nicorandil (NRD), nitroglycerin (NTG), diltiazem (DTZ) and prostaglandin E1 (PGE) on cardiac myocytes incubated under hypothermic conditions. Cardiac myocytes were is