Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Allison Berger"'
Autor:
Todd M. Pitts, Alice McDonald, John J. Tentler, Aik Choon Tan, Kit Man Wong, Peter G Smith, Peter J. Klauck, Stacey M. Bagby, S. Gail Eckhardt, Anna Spreafico, Heather M. Selby, Stephen J. Blakemore, Allison Berger, Lindsey N. Micel
Publikováno v:
Investigational New Drugs. 35:11-25
Background The neddylation pathway conjugates NEDD8 to cullin-RING ligases and controls the proteasomal degradation of specific proteins involved in essential cell processes. Pevonedistat (MLN4924) is a selective small molecule targeting the NEDD8-ac
Autor:
Thea Kalebic, Neeraj Gupta, Lillian L. Siu, John S. Kauh, David Smith, Feng Gao, Ai Min Hui, Jeffrey R. Infante, Gordana Vlahovic, Allison Berger, Jianchang Lin, John A. Thompson, Deborah Berg, Guohui Liu, Stephen Tirrell, Daniel C. Sullivan, Alessandra Di Bacco
Publikováno v:
Investigational New Drugs
SummaryPurpose Ixazomib is an investigational proteasome inhibitor with demonstrated antitumor activity in xenograft models of multiple myeloma (MM), lymphoma, and solid tumors. This open-label, phase 1 study investigated intravenous (IV) ixazomib, i