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Autor:
Todd M. Pitts, Alice McDonald, John J. Tentler, Aik Choon Tan, Kit Man Wong, Peter G Smith, Peter J. Klauck, Stacey M. Bagby, S. Gail Eckhardt, Anna Spreafico, Heather M. Selby, Stephen J. Blakemore, Allison Berger, Lindsey N. Micel
Publikováno v:
Investigational New Drugs. 35:11-25
Background The neddylation pathway conjugates NEDD8 to cullin-RING ligases and controls the proteasomal degradation of specific proteins involved in essential cell processes. Pevonedistat (MLN4924) is a selective small molecule targeting the NEDD8-ac