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Publikováno v:
International Journal of Oral Science, Vol 13, Iss 1, Pp 1-10 (2021)
International Journal of Oral Science
International Journal of Oral Science
Hyperglycemia induces chronic low-grade inflammation (inflammaging), which is a newly identified contributor to diabetes-related tissue lesions, including the inflammatory bone loss in periodontitis. It is also a secondary senescent pattern mediated
Autor:
Bomiao Cui, Jiao Chen, Min Luo, Li-Wei Wang, Die Lü, Ping Zhang, Yiying Liu, Yun Feng, Yingzhu Kang, Hongli Chen, Libin Huang
Publikováno v:
International Journal of Oral Science, Vol 13, Iss 1, Pp 1-10 (2021)
International Journal of Oral Science
International Journal of Oral Science
Background: Oral squamous cell carcinoma (OSCC) has a high incidence of metastasis. Tumor immunotherapy targeting programmed death ligand 1 (PD-L1) or programmed cell death protein 1 (PD-1) is revolutionary; however, only a few patients with OSCC res
Publikováno v:
International Journal of Oral Science, Vol 13, Iss 1, Pp 1-9 (2021)
International Journal of Oral Science
International Journal of Oral Science
Dental pulp can initiate its damage repair after an injury of the pulp–dentin complex by rearrangement of odontoblasts and formation of newly differentiated odontoblast-like cells. Connexin 43 (Cx43) is one of the gap junction proteins that partici
Publikováno v:
International Journal of Oral Science, Vol 12, Iss 1, Pp 1-9 (2020)
International Journal of Oral Science
International Journal of Oral Science
Orofacial pain or tenderness is a primary symptom associated with temporomandibular joint (TMJ) disorders (TMDs). To understand the pathological mechanisms underlying TMDs, several mouse models have been developed, including mechanical stimulus-induc
Publikováno v:
International Journal of Oral Science, Vol 11, Iss 3, Pp 1-8 (2019)
International Journal of Oral Science
International Journal of Oral Science
Dental pulp is composed of nerves, blood vessels, and various types of cells and surrounded by a thick and hard enamel-dentin matrix. Due to its importance in the maintenance of tooth vitality, there have been intensive efforts to analyze the complex
Autor:
Thomas Andl, Yuhang Zhang, Spencer Dunaway, Claudia D. Andl, Ana Luisa Kadekaro, Alexandra Rothaus
Publikováno v:
International Journal of Oral Science, Vol 11, Iss 3, Pp 1-13 (2019)
International Journal of Oral Science
International Journal of Oral Science
Stem cells are of great interest to the scientific community due to their potential role in regenerative and rejuvenative medicine. However, their role in the aging process and carcinogenesis remains unclear. Because DNA replication in stem cells may
Autor:
Jianhua Zhao, Lei Cheng, Benhua Zeng, Jinzhao Yu, Mingyun Li, Bolei Li, Biao Ren, Xuedong Zhou, Wenxia Li, Hong Wei, Yang Ge, Xian Peng
Publikováno v:
International Journal of Oral Science, Vol 11, Iss 1, Pp 1-9 (2019)
International Journal of Oral Science
International Journal of Oral Science
The oral microbiota is associated with oral diseases and digestive systemic diseases. Nevertheless, the causal relationship between them has not been completely elucidated, and colonisation of the gut by oral bacteria is not clear due to the limitati
Publikováno v:
International Journal of Oral Science, Vol 11, Iss 2, Pp 1-12 (2019)
International Journal of Oral Science
International Journal of Oral Science
Genetic studies have revealed a critical role of Distal-homeobox (Dlx) genes in bone formation, and our previous study showed that Dlx2 overexpressing in neural crest cells leads to profound abnormalities of the craniofacial tissues. The aim of this
Autor:
Yongzhen Lai, Caiyu Liao, Di Wu, Yuanjing Jiang, Chuanqing Mao, Hu Zhao, Shixian Zhang, Weihui Chen
Publikováno v:
International Journal of Oral Science, Vol 11, Iss 1, Pp 1-12 (2019)
International Journal of Oral Science
International Journal of Oral Science
The Hedgehog (Hh) signalling pathway is essential for cellular proliferation and differentiation during embryonic development. Gain and loss of function of Hh signalling are known to result in an array of craniofacial malformations. To determine the
Autor:
Shintaro Tsuka, Ryuji Hosokawa, Yuichiro Kusuda, Yusuke Hori, Taro Mukaibo, Chihiro Masaki, Yusuke Kondo, Takashi Munemasa, Yuta Miyagi, Fumiko Aonuma
Publikováno v:
International Journal of Oral Science, Vol 11, Iss 1, Pp 1-8 (2019)
International Journal of Oral Science
International Journal of Oral Science
Corticosteroids are used in the treatment of many diseases; however, they also induce various side effects. Dexamethasone is one of the most potent corticosteroids, and it has been reported to induce the side effect of impaired salivary gland functio