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Autor:
Yoshitake Hayashi, Yoshihiko Yano, Masamitsu Kuriyama, Yasushi Seo, Takeshi Azuma, Hirotaka Kato, Akir A. Miki
Publikováno v:
International Journal of Oncology.
Interferon (IFN) is a multifunctional cytokine which works as a suppressor of hepatocarcinogenesis. Pegylated interferon (PEG-IFN) is a modified form of IFN with different pharmacokinetics. We evaluated the anti-tumor effect of PEG-IFN using a rat he
Autor:
Carol A. Heckman, J. A. Barnes, Yingxin Li, E. Wendt, D. Conway, M. L. Cayer, Nancy S. Boudreau, Sonal Uppal
Publikováno v:
International Journal of Oncology.
Subcellular distribution of mass can be analyzed by a technique that involves culturing cells on interfero- meters and digitizing their interference contours. Contour sampling resulted in 102 variables per cell, which were predictors of oncogenic tra
Autor:
Helin Zhang, Toshio Nikaido, Shigeyuki Kawa, Noriko Watanabe, Moriatsu Izumi, Jun Kamiyama, Sakiko Maruyama, Kazuteru Fukasawa, Miki Wakada, Kaname Yoshizawa, Toshiyuki Sakai, Hirofumi Yokoyama, Yoshinori Takahara, Yoshikazu Sukenaga, Shingo Yogosawa
Publikováno v:
International Journal of Oncology.
We report here that lysocellin, a polyether antibiotic from a streptomycete, induces G1 phase arrest in human osteosarcoma MG63 cells. Lysocellin up-regulates p21WAF1/Cip1 and down-regulates cyclin D1 at the mRNA level. In addition, cyclin D1 is down
Autor:
Yoshirou Matsumoto, Masahiro Inoue, Fumio Imamura, Hiroyuki Nakamura, Mutsuko Mukai, Masaharu Tatsuta, Masako Ayaki, Toshiyuki Kusama
Publikováno v:
International Journal of Oncology.
The mevalonate metabolic pathway is necessary for the isoprenylation of a number of small GTPases. We have previously presented that Rho plays a pivotal role in 1-oleoyl-lysophosphatidic acid (LPA)-induced invasion of rat ascites hepatoma MM1 cells.
Autor:
Gerhard Hamilton, Ruiwen Zhang, Peter Platzer, Gottfried Reznicek, Theresia Thalhammer, Walter Jäger
Publikováno v:
International Journal of Oncology.
10-hydroxycamptothecin (HCPT), a natural analog of the alkaloid camptothecin (CPT), is a promising anticancer agent currently undergoing preclinical trials. Though HCPT is less toxic and more active in various human cancer cell lines and in animal tu
Publikováno v:
Scopus-Elsevier
This report provides evidence linking activation of Ras GTPase by growth factors and induction of glutathione-S-transferase isozymes in PC12 cells. Ras GTPase was activated by EGF, NGF, insulin and phorbolester in PC12 cells. Activation of Ras GTPase
Publikováno v:
International Journal of Oncology.
Effects of vorozole, a potent and specific non-steroidal aromatase inhibitor, were evaluated on female Sprague-Dawley (SD) rats with 7, 12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumors. Vorozole at a dose of 0.25, 1.0 and 4.0 mg/kg was oral
Autor:
Chinthalapally V. Rao, Ben Yi Ji, Jose G. Rosa Rodriguez, Toshihiko Kawamori, Bandaru S. Reddy, Karam El-Bayoumy
Publikováno v:
International Journal of Oncology.
Observational, clinical and experimental studies have suggested that dietary supplementation with selenium can inhibit the development of colon cancer. Since toxicity and chemopreventive efficacy of selenium compounds depend to a large extent, on the