Zobrazeno 1 - 10
of 3 719
pro vyhledávání: ''
Autor:
Gerard M.J. de Wit, Richard T. Jaspers, Daniel Jacko, Henning Wackerhage, Lian E.M. Stadhouders, Ilse S.P. Vogel, Martin Schönfelder, Thorben Aussieker, Carla Offringa, Sebastian Gehlert, Sander A.J. Verbrugge
Publikováno v:
Verbrugge, S A J, Gehlert, S, Stadhouders, L E M, Jacko, D, Aussieker, T, de Wit, G M J, Vogel, I S P, Offringa, C, Schönfelder, M, Jaspers, R T & Wackerhage, H 2020, ' PKM2 determines myofiber hypertrophy in vitro and increases in response to resistance exercise in human skeletal muscle ', International Journal of Molecular Sciences, vol. 21, no. 19, 7062, pp. 1-15 . https://doi.org/10.3390/ijms21197062
International Journal of Molecular Sciences
International Journal of Molecular Sciences, 21(19):7062, 1-15. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, Vol 21, Iss 7062, p 7062 (2020)
Volume 21
Issue 19
International Journal of Molecular Sciences
International Journal of Molecular Sciences, 21(19):7062, 1-15. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, Vol 21, Iss 7062, p 7062 (2020)
Volume 21
Issue 19
Nearly 100 years ago, Otto Warburg investigated the metabolism of growing tissues and discovered that tumors reprogram their metabolism. It is poorly understood whether and how hypertrophying muscle, another growing tissue, reprograms its metabolism
Autor:
Mari Hämäläinen, Antti Pemmari, Lauri J. Moilanen, Lauri Tuure, Riina Nieminen, Teemu Moilanen, E. Nummenmaa, Eeva Moilanen, Katriina Vuolteenaho
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 87, p 87 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 1
International Journal of Molecular Sciences
Volume 22
Issue 1
Transient receptor potential ankyrin 1 (TRPA1) is a membrane-bound ion channel found in neurons, where it mediates nociception and neurogenic inflammation. Recently, we have discovered that TRPA1 is also expressed in human osteoarthritic (OA) chondro
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 112, p 112 (2021)
International Journal of Molecular Sciences; Volume 22; Issue 1; Pages: 112
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 22; Issue 1; Pages: 112
International Journal of Molecular Sciences
Using a data driven analysis of a high-content screen, we have uncovered new regulators of epithelial-to-mesenchymal transition (EMT) induced cell migration. Our results suggest that increased expression of miR614 can alter cell intrinsic gene expres
Autor:
Keisuke Nishiura, Takashi Kanda, Naoki Ichikawa-Tomikawa, Yasuteru Sano, Yasuto Kunii, Tetsuya Imura, Hideki Chiba, Fumitaka Shimizu, Kotaro Sugimoto, Akiyoshi Kakita
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 254, p 254 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 1
International Journal of Molecular Sciences
Volume 22
Issue 1
We previously reported that site-selective claudin-5 (CLDN5) breakdown and protein kinase A (PKA) activation are observed in brain microvessels of schizophrenia, but the underlying molecular basis remains unknown. The 5-HT1 receptors decline the intr
Autor:
Ryota Chijimatsu, Takuya Ishimoto, Kenji Takami, Takayoshi Nakano, Kosuke Ebina, Atsushi Goshima, Takashi Kanamoto, Akira Miyama, Yuki Etani, Yasukazu Yonetani, Masayuki Hamada, Gensuke Okamura, Ken Nakata, Makoto Hirao, Hideki Yoshikawa
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 300, p 300 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 1
International Journal of Molecular Sciences
Volume 22
Issue 1
Synovial mesenchymal stem cell (SMSC) is the promising cell source of cartilage regeneration but has several issues to overcome such as limited cell proliferation and heterogeneity of cartilage regeneration ability. Previous reports demonstrated that
Autor:
Saeed Y. Al-ramadan, Fatma J. Al-Saeedi, A. M. Soliman, Gamal M. Bekhet, Maged E. Mohamed, Rebai Ben Ammar, Medhat Ahmed El-Naggar, Peramaiyan Rajendran
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 217, p 217 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 1
International Journal of Molecular Sciences
Volume 22
Issue 1
In this study, kaempferol (KFL) shows hepatoprotective activity against zearalenone (ZEA)-induced oxidative stress and its underlying mechanisms in in vitro and in vivo models were investigated. Oxidative stress plays a critical role in the pathophys
Autor:
Claudia Sissi, Mery Giantin, Silvia Ceschi, Riccardo Rigo, Giulia Nicoletto, Silvia Da Ros, Eleonora Zorzan, Mauro Dacasto
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 329, p 329 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 1
International Journal of Molecular Sciences
Volume 22
Issue 1
The regulation of conformational arrangements of gene promoters is a physiological mechanism that has been associated with the fine control of gene expression. Indeed, it can drive the time and the location for the selective recruitment of proteins o
Conformational Models of APP Processing by Gamma Secretase Based on Analysis of Pathogenic Mutations
Autor:
Ilya Bezprozvanny, Mee Whi Kim
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 13600, p 13600 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Proteolytic processing of amyloid precursor protein (APP) plays a critical role in pathogenesis of Azheimer’s disease (AD). Sequential cleavage of APP by β and γ secretases leads to generation of Aβ40 (non-amyloidogenic) and Aβ42 (amyloidogenic
Autor:
Sun-Hee Woo, Tran Nguyet Trinh
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 251, p 251 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
ATP is a major energy source in the mammalian cells, but it is an extracellular chemical messenger acting on P2 purinergic receptors. A line of evidence has shown that ATP is released from many different types of cells including neurons, endothelial
Autor:
Dmitry L. Aminin, Peter Illes
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 12895, p 12895 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 12895, p 12895 (2021)
ATP is stored in millimolar concentrations within the intracellular medium but may be released to extracellular sites either through the damaged plasma membrane or by means of various transporters [...]