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pro vyhledávání: ''
Autor:
Mari Hämäläinen, Antti Pemmari, Lauri J. Moilanen, Lauri Tuure, Riina Nieminen, Teemu Moilanen, E. Nummenmaa, Eeva Moilanen, Katriina Vuolteenaho
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 87, p 87 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 1
International Journal of Molecular Sciences
Volume 22
Issue 1
Transient receptor potential ankyrin 1 (TRPA1) is a membrane-bound ion channel found in neurons, where it mediates nociception and neurogenic inflammation. Recently, we have discovered that TRPA1 is also expressed in human osteoarthritic (OA) chondro
Autor:
Ryota Chijimatsu, Takuya Ishimoto, Kenji Takami, Takayoshi Nakano, Kosuke Ebina, Atsushi Goshima, Takashi Kanamoto, Akira Miyama, Yuki Etani, Yasukazu Yonetani, Masayuki Hamada, Gensuke Okamura, Ken Nakata, Makoto Hirao, Hideki Yoshikawa
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 300, p 300 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 1
International Journal of Molecular Sciences
Volume 22
Issue 1
Synovial mesenchymal stem cell (SMSC) is the promising cell source of cartilage regeneration but has several issues to overcome such as limited cell proliferation and heterogeneity of cartilage regeneration ability. Previous reports demonstrated that
Autor:
Benedikt Schrage, Jacob Schön, Elke Hammer, Svenja Warnke, Diana Lindner, Hanna Bräuninger, Uwe Völker, Stefan Blankenberg, Katharina Scherschel, Dirk Westermann, Tilo Thottakara, Paulus Kirchhof, Vishnu M. Dhople, Svenja Voss
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12262, p 12262 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 22
International Journal of Molecular Sciences
Volume 22
Issue 22
Fibroblasts contribute to approximately 20% of the non-cardiomyocytic cells in the heart. They play important roles in the myocardial adaption to stretch, inflammation, and other pathophysiological conditions. Fibroblasts are a major source of extrac
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12788, p 12788 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12788
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12788
The skin is subject to both intrinsic aging caused by metabolic processes in the body and extrinsic aging caused by exposure to environmental factors. Intrinsic aging is an important obstacle to in vitro experimentation as its long-term progression i
Autor:
Claire Rhee, Qi Gao, Elijah Ejun Huang, Rocky S. Tuan, Michael S. Gold, Hang Lin, Zhenyu Yao, Masahiro Maruyama, Bruce A. Bunnell, Shiqi Xiang, Zhong Li, Stuart B. Goodman
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12837, p 12837 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12837
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12837
Fibroblasts in the synovial membrane secrete molecules essential to forming the extracellular matrix (ECM) and supporting joint homeostasis. While evidence suggests that fibroblasts contribute to the response to joint injury, the outcomes appear to b
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12039, p 12039 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 21
International Journal of Molecular Sciences
Volume 22
Issue 21
Purpose: The objective of the current study was to evaluate the effects of the autotaxin (ATX)–lysophosphatidic acid (LPA) signaling axis on the human trabecular meshwork (HTM) in two-dimensional (2D) and three-dimensional (3D) cultures of HTM cell
Autor:
Thao Thi Dang, Sung Hoon Back
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12083, p 12083 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 21
International Journal of Molecular Sciences
Volume 22
Issue 21
The autophagy-lysosome pathway is a major protein degradation pathway stimulated by multiple cellular stresses, including nutrient or growth factor deprivation, hypoxia, misfolded proteins, damaged organelles, and intracellular pathogens. Recent stud
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 21
International Journal of Molecular Sciences, Vol 22, Iss 11911, p 11911 (2021)
Volume 22
Issue 21
International Journal of Molecular Sciences, Vol 22, Iss 11911, p 11911 (2021)
Exposure to microgravity affects astronauts’ health in adverse ways. However, less is known about the extent to which fibroblast differentiation during the wound healing process is affected by the lack of gravity. One of the key steps of this proce
Autor:
Rafał Szychowski, Sylwia Bobis-Wozowicz, Kinga Nit, Dawid Wnuk, Marta Michalik, Zbigniew Madeja, Alicja Ślusarczyk, Milena Paw
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12790, p 12790 (2021)
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12790
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12790
International Journal of Molecular Sciences
Subepithelial fibrosis is a component of the remodeling observed in the bronchial wall of patients diagnosed with asthma. In this process, human bronchial fibroblasts (HBFs) drive the fibroblast-to-myofibroblast transition (FMT) in response to transf
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 20
International Journal of Molecular Sciences, Vol 22, Iss 10993, p 10993 (2021)
Volume 22
Issue 20
International Journal of Molecular Sciences, Vol 22, Iss 10993, p 10993 (2021)
Extracellular vesicles (EVs) are secreted from hADSCs in low concentrations, which makes it difficult to utilize them for the development of therapeutic products. To overcome the problem associated with low concentration, we proposed human lactoferri