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Autor:
Zhangang Xiao, Jianhua Yin, Fukuan Du, Yuchen Zhang, Chengliang Huang, Yuanlin Wu, Parham Jabbarzadeh Kaboli, Jing Shen, Dandan Yuan, Chi Hin Cho, Xu Wu, Zhuo Zhang, Jing Li, Hanyu Zhang, Yueshui Zhao, Lan Lu, Mingxing Li
Publikováno v:
International Journal of Molecular Medicine
Cluster of differentiation 44 (CD44) as a transmembrane glycoprotein is found to be expressed in non-small cell lung cancer (NSCLC), is significantly associated with NSLC progression, metastasis and drug resistance. This study aimed to explore whethe
Autor:
Denisa Margina, Valentina Anuta, Octavian Tudorel Olaru, Aristidis Tsatsakis, Demetrios A. Spandidos, George Mihai Nitulescu, Cristina Dinu Pirvu, Oana Cristina Seremet, Anca Zanfirescu, Georgiana Nitulescu
Publikováno v:
International Journal of Molecular Medicine
The use of alternative techniques to reduce the number of animals used in anticancer research is an issue of current interest. The aim of this study was to validate the use of a simple and efficient alternative tool for the assessment of the potentia
Autor:
Peng Gao, Jianglun Shen, Jian Sun, Lu Wang, Haifeng Cai, Yiming Yang, Yanqin Lu, Yang Zhang, Zhiguo Sun, Ning Li, Hao Dai
Publikováno v:
International Journal of Molecular Medicine
Triple-negative breast cancer (TNBC) is a type of breast cancer that is characterized by the lack of expression of estrogen and progesterone receptors, and epidermal growth factor receptor 2. Therefore, there is an absence of a specific target for ef
Publikováno v:
International Journal of Molecular Medicine.
In gastric cancer, >15% of cases are associated with the amplification of human epidermal growth factor receptor 2 (HER2), which leads to poor clinical outcomes. Lapatinib, a potent ATP‑competitive inhibitor, is a small, orally active molecule, whi
Publikováno v:
International Journal of Molecular Medicine. 35:1088-1094
Evidence has been accumulating for a role for metformin in reducing breast cancer risk in post-menopausal women. It inhibits growth of breast cancer cells via several mechanisms, primarily the AMPK/mTOR signalling pathway. Another possible protective
Publikováno v:
International Journal of Molecular Medicine. 26
Hepatocellular carcinoma (HCC) is one of major health concerns worldwide and one of leading causes of cancer death after lung and gastric cancers. Simvastatin is a cholesterol-lowering drug which inhibits 3-hydroxy-3-methylglutarylcoenzyme CoA (HMG-C
Publikováno v:
International Journal of Molecular Medicine.
GSTP1, which encodes GSTPi, has a polymorphic site at codon 105 (exon 5), where an adenosine-to-guanine (A-G) transition causes an isoleucine-to-valine substitution (I105V). Recent studies have found that subjects with the valine allele display a sig
Caspase-1 activity as a possible predictor of apoptosis induced by cisplatin in gastric cancer cells
Autor:
Kazuya Muguruma, Bunzo Nakata, Naoyoshi Onoda, Kenichi Yanagawa, Atsunori Nitta, Kousei Hirakawa, Masakazu Yashiro
Publikováno v:
International Journal of Molecular Medicine.
Recent studies have shown that caspases, which are cystein proteases, elevate endonuclease activity and induce apoptosis. Caspase-1, an interleukin-1beta converting enzyme, has been reported to be related with anti-cancer drug induced apoptosis as we
Publikováno v:
International Journal of Molecular Medicine.
Anticancer nucleoside analogs (e.g., ara-C, gemcitabine, fludarabine) induce apoptosis by incorporation into DNA. Removal of incorporated analogs from DNA by 3'-5' exonucleases is presumably a mechanism of drug resistance. Based on our previous obser
Autor:
Tetsuya Ohtsuki, M Ikeda, T Saito, Kazuma Ikeda, H Takahashi, T Takizawa, Kiyohiko Hatake, Hiroshi Tomizuka, S Yonehara, Y Miura, Yoshiaki Hoshino, Y Gunji
Publikováno v:
International Journal of Molecular Medicine.
We describe a predictive marker (CD95) for the responsiveness to tretinoin (RA) in acute promyelocytic leukemia (APL). Functional CD95 expression during RA treatment have been observed only in those patients who responded to RA. Expression of CD95 (F