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Autor:
Kinya Nagata, Masayuki Nagasawa, Masakatsu Yanagimachi, Tetsuya Fukuda, Noriko Mitsuiki, Tomohiro Morio, Masahide Yamamoto, Akira Igarashi, Osamu Miura, Ryutaro Oba
Publikováno v:
International Journal of Hematology. 113:910-920
We have recently reported a new method for detecting T-cell-derived extracellular vesicles (EVs), CD3+CD4+EVs,CD3+CD8+EVs, and CD3+HLA-DR+EVs. In our previous study, CD3+HLA-DR+EVs were released profusely by CD8+T cells, only moderately by T helper1
Publikováno v:
International Journal of Hematology. 91:293-302
This study aims to investigate the role of stromal cell-derived factor 1alpha (SDF-1alpha) and its receptor CXCR4 in cellular infiltration of the lung in differentiation syndrome (DS). The acute promyelocytic leukemia (APL) NB4 cells and freshly prep
Autor:
Seonyang Park, Eun Kyung Bae, Byoung Kook Kim, Young Yiul Lee, Dong Soon Lee, Jae Hoon Lee, Youngil Koh, Juwon Park, Sung-Soo Yoon, Soo Mee Bang, Kwang Sung Ahn, Inho Kim
Publikováno v:
International Journal of Hematology. 90:1-5
Mutations of nucleophosmin gene (NPM1) are known to be related to good prognosis in AML patients lacking FLT3 internal tandem duplication (FLT3-ITD). Recently, NPM1 mutations other than type A were reported, but their clinical significance is not wel
Autor:
Dimitrios Spentzos, Wolf Christian Prall, Norbert Gattermann, Hasan H. Otu, Astrid Rong, Akos Czibere, Ulrich Germing, Rainer Haas, Manuel Aivado, Andrea Kuendgen, Ulrich Steidl, Aristoteles Giagounidis, Towia A. Libermann, Franck Grall
Publikováno v:
International Journal of Hematology. 89:173-187
One feature of the molecular pathology of myelodysplastic syndromes (MDS) is aberrant gene expression. Such aberrations may be related to patient survival, and may indicate to novel diagnostic and therapeutic targets. Therefore, we aimed at identifyi
Autor:
Yoshiaki Ogawa, Masako Shimada, Kiyoshi Ando, Kaori Okamura, Kosuke Tsuboi, Tomomitsu Hotta, Hiroshi Kawada, Ako Kikuchi, Rikio Suzuki, Hiroyuki Kobayashi, Minoru Kojima, Satomi Fukagawa, Ayumi Shintani, Makoto Onizuka
Publikováno v:
International Journal of Hematology. 86:422-428
Mutations in the fms-like tyrosine kinase 3 (FLT3) gene containing an internal tandem duplication (FLT3/ITD) or mutations in the nucleophosmin 1 gene (NPM1) are thought to be prognostic indicators in acute myeloid leukemia (AML). Previous studies sug
Autor:
Toshiyuki Izumo, Takaaki Shikano, Nobuo Maseki, Yoshihiro Komada, Takeshi Namiki, Masahiro Kikuchi, Junji Suzumiya, Atsushi Kikuta, Shoichi Koizumi, Yasuhiko Kaneko, Hirofumi Kobayashi, Akiko Sakashita, A Watanabe
Publikováno v:
International Journal of Hematology. 77:490-498
To clarify the clinical and genetic features of Burkitt lymphoma with or without leukemic presentation, we have conducted clinical, cytogenetic, and genetic studies. Of 40 Japanese patients with Burkitt lymphoma examined by cytogenetic and/or fluores