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Autor:
Bing Han, Yan Li, Jordi Canals, Carmen Muñoz, I. Moreno, Mariano Monzo, Joan J. Castellano, Raquel Hernández, Alfons Navarro, Francisco Martínez-Rodenas
Publikováno v:
International Journal of Colorectal Disease. 35:805-813
In colorectal cancer (CRC), circulating tumor cells (CTCs) are released into the mesenteric veins (MV). We chose to determine whether KRAS mutations detected in CTCs from blood obtained at the time of surgery could be a marker of survival. From 52 su
Autor:
Elisabeth Kremmer, Michael Stürzl, Jürgen Behrens, Elisabeth Naschberger, Roland S. Croner, Sandra Grenz, Susanne Merkel, Priya Chudasama, Michel V. Hadjihannas, Ute Schaal, Tilman T. Rau
Publikováno v:
International Journal of Colorectal Disease. 28:1469-1478
Aberrant activation of the Wnt/β-catenin pathway plays a major role in the development of colorectal carcinoma (CRC). Axin 2 is a key protein of this pathway and is upregulated in CRC. Here, we investigated RNA- and protein expression of axin 2 in C
Autor:
Qun Qian, Lifang Fan, Honglei Chen, Jun-Qiu Yue, Congqing Jiang, Jing-Ling Xue, Yan Wang, Guifang Yang, Zhi-Gao Xu, Jing Guan
Publikováno v:
International Journal of Colorectal Disease. 28:1329-1335
Background and aims Molecular testing for epidermal growthfactorreceptor(EGFR)mutationshasrecentlybecome a standard practice for the management of patients with nonsquamous none small cell lung cancer. Primary small intestine adenocarcinoma (SIA) is
Publikováno v:
International Journal of Colorectal Disease. 28:933-940
Colorectal cancer is a common malignancy and one of the major causes of cancer-related deaths worldwide. Similar to other human cancers, tumor metastasis is the biggest obstacle in the clinical treatment of colorectal cancer. In this study, we explor
Autor:
Soong Lee, Ki-Sang Lee, Se-Min Hwang, Hwan-Young Kim, David G. Hwang, Seung-Chul Pack, Sang-Wook Park, Jung-Yun Ko, Gun-Young Hong, Hoon Kang, Sang Woo Lim, Seong-Il Park, Hye-Ran Kim, Myung-Geun Shin
Publikováno v:
International Journal of Colorectal Disease. 28:139-147
The purpose of present study was to investigate the methylation status of the promoter region in five genes (mothers against decapentaplegic homolog 4, fragile histidine triad protein, death-associated protein kinase 1, adenomatous polyposis coli (AP
Autor:
Clemens Schafmayer, Holger Kalthoff, Stephan Buch, Jesús Lascorz, Thomas Becker, Jan Henrik Beckmann, Witigo von Schönfels, Jochen Hampe, Melanie Bevier, Jan Hendrik Egberts, Kari Hemminki, Heiko Aselmann, Stefan Schreiber, Asta Försti
Publikováno v:
International Journal of Colorectal Disease. 28:173-181
We identified recently the extracellular matrix (ECM) receptor interaction pathway as a consistently overrepresented category among gene expression profiling studies on colorectal cancer (CRC) prognosis.Putative regulatory single nucleotide polymorph
Autor:
Ugonna Ihenacho, Christopher K. Edlund, Jane C. Figueiredo, Robert W. Haile, A. Joan Levine, Brian D. Davis, Mariana C. Stern, Won Lee, David J. Vandenberg
Publikováno v:
International Journal of Colorectal Disease. 27:1587-1595
Insulin, glucose, and other insulin-related proteins that mediate insulin signaling are associated with colorectal neoplasia risk, but associations with common genetic variation in insulin axis genes are less clear. In this study, we used a comprehen
Autor:
Marko Kornmann, Andrea Formentini, Karl-Heinrich Link, Harald Fricke, Doris Henne-Bruns, Philipp Braun
Publikováno v:
International Journal of Colorectal Disease. 27:1369-1376
Interleukin-4 (IL-4) and interleukin-13 (IL-13) are anti-inflammatory and immunomodulatory cytokines which can influence cancer-directed immunosurveillance. Nothing is presently known about expression of these cytokines and their receptors (IL-4R and
Autor:
Yuan Chen, Utz Settmacher, Thomas Knösel, Iver Petersen, Stefanie Hotovy, Annelore Altendorf-Hofmann
Publikováno v:
International Journal of Colorectal Disease. 27:1391-1399
Genomewide expression profiling has identified a number of genes differentially expressed in colorectal carcinomas (CRCs) compared to normal tissue. Some of these genes were linked to epithelial-mesenchymal transition. We tested whether genes includi
Publikováno v:
International Journal of Colorectal Disease. 27:911-919
High level of microsatellite instability (MSI-H) in colorectal cancer (CRC) is caused by the inactivation of mismatch repair (MMR) genes; however, it is unknown for tumors with low level MSI (MSI-L). The protein complex involving MSH3 preferentially