Zobrazeno 1 - 10
of 22
pro vyhledávání: ''
Autor:
Bing Han, Yan Li, Jordi Canals, Carmen Muñoz, I. Moreno, Mariano Monzo, Joan J. Castellano, Raquel Hernández, Alfons Navarro, Francisco Martínez-Rodenas
Publikováno v:
International Journal of Colorectal Disease. 35:805-813
In colorectal cancer (CRC), circulating tumor cells (CTCs) are released into the mesenteric veins (MV). We chose to determine whether KRAS mutations detected in CTCs from blood obtained at the time of surgery could be a marker of survival. From 52 su
Autor:
Elisabeth Kremmer, Michael Stürzl, Jürgen Behrens, Elisabeth Naschberger, Roland S. Croner, Sandra Grenz, Susanne Merkel, Priya Chudasama, Michel V. Hadjihannas, Ute Schaal, Tilman T. Rau
Publikováno v:
International Journal of Colorectal Disease. 28:1469-1478
Aberrant activation of the Wnt/β-catenin pathway plays a major role in the development of colorectal carcinoma (CRC). Axin 2 is a key protein of this pathway and is upregulated in CRC. Here, we investigated RNA- and protein expression of axin 2 in C
Autor:
Soong Lee, Ki-Sang Lee, Se-Min Hwang, Hwan-Young Kim, David G. Hwang, Seung-Chul Pack, Sang-Wook Park, Jung-Yun Ko, Gun-Young Hong, Hoon Kang, Sang Woo Lim, Seong-Il Park, Hye-Ran Kim, Myung-Geun Shin
Publikováno v:
International Journal of Colorectal Disease. 28:139-147
The purpose of present study was to investigate the methylation status of the promoter region in five genes (mothers against decapentaplegic homolog 4, fragile histidine triad protein, death-associated protein kinase 1, adenomatous polyposis coli (AP
Autor:
Marko Kornmann, Andrea Formentini, Karl-Heinrich Link, Harald Fricke, Doris Henne-Bruns, Philipp Braun
Publikováno v:
International Journal of Colorectal Disease. 27:1369-1376
Interleukin-4 (IL-4) and interleukin-13 (IL-13) are anti-inflammatory and immunomodulatory cytokines which can influence cancer-directed immunosurveillance. Nothing is presently known about expression of these cytokines and their receptors (IL-4R and
Autor:
Yuan Chen, Utz Settmacher, Thomas Knösel, Iver Petersen, Stefanie Hotovy, Annelore Altendorf-Hofmann
Publikováno v:
International Journal of Colorectal Disease. 27:1391-1399
Genomewide expression profiling has identified a number of genes differentially expressed in colorectal carcinomas (CRCs) compared to normal tissue. Some of these genes were linked to epithelial-mesenchymal transition. We tested whether genes includi
Publikováno v:
International Journal of Colorectal Disease. 27:911-919
High level of microsatellite instability (MSI-H) in colorectal cancer (CRC) is caused by the inactivation of mismatch repair (MMR) genes; however, it is unknown for tumors with low level MSI (MSI-L). The protein complex involving MSH3 preferentially
Autor:
Anna Vaiopoulou, Myrto Leandrou, Sofia Nikouli, Efthimia Vassou, George Theodoropoulos, Nikolaos Nikiteas, Maria Gazouli, Gregory Kouraklis
Publikováno v:
International Journal of Colorectal Disease. 26:1113-1118
Caspase-8 (CASP8) and caspase-9 (CASP9) play crucial roles in regulating apoptosis, and their functional polymorphisms may alter cancer risk. Our aim was to investigate the association between CASP8 and CASP9 gene polymorphisms and colorectal cancer
Autor:
Shiva Gautam, Lydia Kriegl, Jutta M. Nagel, Frank T. Kolligs, Christos S. Mantzoros, David Horst, Jutta Engel, Thomas Kirchner, Burkhard Göke
Publikováno v:
International Journal of Colorectal Disease. 25:1301-1309
Expression and role of γ-catenin in colorectal carcinogenesis is not well understood. We aimed at characterizing γ-catenin's expression pattern during colorectal carcinogenesis.The expression pattern of γ-catenin was characterized in adenomas, pri
Autor:
Desen Wan, Zhizhong Pan, Yu Jing Fang, Guo Qiang Wang, M. F. Zhang, Jun-Ping Yun, Zhi-Wei Zhou, Zhenhai Lu
Publikováno v:
International Journal of Colorectal Disease. 24:875-884
Colorectal cancer is one of the most common cancers worldwide. We tested the hypothesis that differences in the expression of certain molecular markers of colon cancer may account for different clinical outcomes.Tissue microarray technology was used
Publikováno v:
International Journal of Colorectal Disease. 24:171-175
Colorectal cancer incidence and prognosis are influenced by vitamin D intake and expression of the vitamin D receptor (VDR). Polymorphisms of the VDR are linked to several diseases. This study was aimed to investigate whether variants of the VDR poly