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pro vyhledávání: '"63"'
Autor:
Germán Rodríguez, Cristina Bilbao, Raquel Ramírez, Orlando Falcón, Laureano León, Ricardo Chirino, B. Pilar Díaz, Juan F. Rivero, Manuel Perucho, B. Nicolás Díaz-Chico, Juan C. Díaz-Chico
Publikováno v:
International Journal of Cancer. 118:1420-1425
The human androgen receptor (AR) gene possesses 2 trinucleotide repeats of CAG and GGN in exon 1. The CAG repeat corresponds to a polyglutamine tract in the N-terminal region of the receptor, that affects its transcriptional efficiency. The GGN repea
Autor:
Chong-Jen Yu, Jin-Yuan Shih, Chih-Hsin Yang, Kuan-Yu Chen, Wen Pin Su, Chien Hung Gow, Ya-Chieh Hsu, Yih-Leong Chang, Pan-Chyr Yang, Meng-Feng Tsai
Publikováno v:
International Journal of Cancer. 118:963-969
Recently, mutations in the epidermal growth factor receptor (EGFR) gene in nonsmall cell lung cancer (NSCLC) patients were reported to correlate with gefitinib response. Less than 30% of NSCLC patients are surgically resectable; however, molecular an
Publikováno v:
International journal of cancer. 84(4)
The DNA-repair protein O(6)-methylguanine-DNA methyltransferase (alkyltransferase; MGMT) is a major determinant of resistance of cells to various alkylating cytostatic drugs. Its expression in tissues is highly variable, indicating complex regulatory