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Autor:
Dirk Andreas Ridder, Arndt Weinmann, Mario Schindeldecker, Lana Louisa Urbansky, Kristina Berndt, Tiemo Sven Gerber, Hauke Lang, Johannes Lotz, Karl J. Lackner, Wilfried Roth, Beate Katharina Straub
Publikováno v:
International Journal of Cancer. 150:1053-1066
Alpha fetoprotein (AFP) is the most widely used diagnostic and prognostic serum biomarker for hepatocellular carcinoma (HCC). Despite its wide clinical use, a systematic clinicopathologic study comparing AFP expression in HCC in situ with serum AFP c
Autor:
Roy Zvi Granit, Evandro de Azambuja, Giancarlo Pruneri, Amir Sonnenblick, Nadia Harbeck, Christos Sotiriou, Dominique Agbor-Tarh, Ibrahim Fahoum, Alvaro Moreno-Aspita, Miguel Izquierdo, Minetta C. Liu, Martine Piccart, Susanne Hultsch, Ghizlane Rouas
Publikováno v:
International journal of cancer
The JAK/STAT3 signaling pathway may be aberrantly activated and have various and conflicting roles in breast cancer. The current study explored prognostic implications of activated STAT3 in human epidermal growth factor receptor 2 (HER2)-positive pri
Autor:
Yuqiao Sheng, Feng Li, Jingjing Xu, Shengli Ma, Xiaoping Shang, Yang Yang, Zhihai Qin, Na Wei, Xixi Duan, Jiajia Wan, Rui Xue
Publikováno v:
International Journal of Cancer. 148:1519-1528
To investigate the clinical value of Tie2-expressing monocytes (TEMs) in the early diagnosis of lung cancer and assess its correlation with angiogenesis, a total of 184 patients with non-small cell lung cancer (NSCLC), 101 patients with benign pulmon
Publikováno v:
International Journal of Cancer. 148:459-468
Clear cell carcinomas (CCCs) of the gynecologic tract are aggressive tumors with high resistance rate to conventional platinum-based chemotherapies. Currently, the molecular features of these tumors remain largely unknown and there is no targeted the
Autor:
Sora Kim, Soonmyung Paik, Su Bin Jo, Dachan Kim, Hanna Lee, Yu‐Jin Jung, Jung Eun Shim, So Hee Kim, Su‐Jin Bae, Jung Yun Lee, Hyun Soo Kim, Yong Jae Lee
Publikováno v:
International Journal of Cancer. 146:1851-1861
The goal of our study was to demonstrate the spectrum of genomic alterations present in the residual disease of patients with advanced high-grade serous ovarian cancer (HGSOC) after neoadjuvant chemotherapy (NAC), including matched pretreatment biops
Autor:
Patrick Volkir, Jim Ranger-Moore, Mark H. Stoler, Thomas C. Wright, R. Ridder, Qijun Fang, Mahboobeh Safaeian
Publikováno v:
International journal of cancer. 150(3)
Triage strategies are needed for primary human papillomavirus (HPV)-based cervical cancer screening to identify women requiring colposcopy/biopsy. We assessed the performance of p16/Ki-67 dual-stained (DS) immunocytochemistry to triage HPV-positive w
Autor:
Shao Hui Huang, Jianjun Ren, Raymond Jang, Maryam Mirshams, Yu Zhao, Bayardo Perez-Ordonez, Rayjean J. Hung, Dangxiao Cheng, David P. Goldstein, Jie Su, Steven Habbous, Xue Ren, Zhuo Chen, Jennifer Wang, Scott V. Bratman, Geoffrey Liu, Wei Xu, Noemi Bender, Tim Waterboer, John R. de Almeida
Publikováno v:
International Journal of Cancer. 146:2166-2174
In cancer epidemiological studies, determination of human papillomavirus (HPV) in oropharyngeal squamous cell carcinoma (OPSCC) typically depends on the availability of tumor tissue testing, and/or tumor tissue access. Identifying alternative methods
Publikováno v:
International Journal of Cancer. 145:1138-1147
Colorectal carcinoma is one of the most common types of malignancy and a leading cause of cancer related death. The aberrant expression of a brown fat-like phenotype in cancer cells has been previously implicated in tumour growth. Therefore, the expr
Autor:
Epie Boven, Mark Opdam, Sabine C Linn, Xanthippi Alexi, Dinja T. Kruger, Karianne Schuurman, Wilbert Zwart, Leonie Voorwerk, Vincent van der Noort, Joyce Sanders
Publikováno v:
International Journal of Cancer
International Journal of Cancer, 146(8), 2348-2359. Wiley-Liss Inc.
Kruger, D T, Alexi, X, Opdam, M, Schuurman, K, Voorwerk, L, Sanders, J, van der Noort, V, Boven, E, Zwart, W & Linn, S C 2020, ' IGF-1R pathway activation as putative biomarker for linsitinib therapy to revert tamoxifen resistance in ER-positive breast cancer ', International Journal of Cancer, vol. 146, no. 8, pp. 2348-2359 . https://doi.org/10.1002/ijc.32668
International Journal of Cancer, 146(8), 2348-2359. Wiley-Liss Inc.
Kruger, D T, Alexi, X, Opdam, M, Schuurman, K, Voorwerk, L, Sanders, J, van der Noort, V, Boven, E, Zwart, W & Linn, S C 2020, ' IGF-1R pathway activation as putative biomarker for linsitinib therapy to revert tamoxifen resistance in ER-positive breast cancer ', International Journal of Cancer, vol. 146, no. 8, pp. 2348-2359 . https://doi.org/10.1002/ijc.32668
Preclinical studies indicate that activated IGF‐1R can drive endocrine resistance in ER‐positive (ER+) breast cancer, but its clinical relevance is unknown. We studied the effect of IGF‐1R signaling on tamoxifen benefit in patients and we searc
Autor:
Miyako Hatano, Yosuke Nakanishi, Kosho Wakae, Makiko Moriyama-Kita, Hisashi Sugimoto, Satoru Kondo, Makoto Kano, Masamichi Muramatsu, Naohiro Wakisaka, Mituharu Aga, Takayoshi Ueno, Kouichi Kitamura, Kazuya Ishikawa, Kazuhira Endo, Tomokazu Yoshizaki
Publikováno v:
International journal of cancer. 145(6)
Human papillomavirus (HPV) has been identified as a causative agent of cervical cancer and oropharyngeal cancer (OPC). Intriguingly, estrogen and HPV were shown to play synergistic roles in cervical carcinogenesis. We recently demonstrated that the a