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Autor:
Mitra Mosslemi, Kelsie L. Thu, Daiana D. Becker-Santos, Emily A. Vucic, Victor D. Martinez, Larissa A. Pikor, Adi F. Gazdar, Sonia H. Y. Kung, Wan L. Lam, Stephen Lam, Roland Hubaux
Publikováno v:
International Journal of Cancer. 137:2072-2082
Microtubule affinity-regulating kinases (MARKs) are involved in several cellular functions but few studies have correlated MARK kinase expression with cancer, and none have explored their role in lung cancer. In this study, we identified MARK2 as fre
Autor:
Denis Lane, Claude Laplante, Claudine Rancourt, Alain Piché, Isabelle Matte, Perrine Garde-Granger
Publikováno v:
International Journal of Cancer. 137:289-298
Ovarian cancer ascites consist of a proinflammatory environment that is characterized by the presence of abundant human peritoneal mesothelial cells (HPMCs). Cytokines and growth factors in ascites modulate cell activities of tumor cells. The express
Autor:
Wolfgang Deppert, Florian Wegwitz, Katharina Jannasch, Claudia Maenz, Eva Lenfert, Frauke Alves
Publikováno v:
International Journal of Cancer. 137:25-36
In this study, the effects of the standard chemotherapy, cyclophosphamide/adriamycin/5-fluorouracil (CAF) on tumor growth, dissemination and recurrence after orthotopic implantation of murine G-2 cells were analyzed in the syngeneic immunocompetent w
Autor:
Mikko Siurala, Simona Bramante, Markus Vähä-Koskela, Anja Kipar, Siri Tähtinen, Anna Kanerva, Suvi Parviainen, Kilian Guse, Mari Hirvinen, Lotta Vassilev, Vincenzo Cerullo, Akseli Hemminki
Publikováno v:
International Journal of Cancer. 136:945-954
Despite originating from several different tissues, soft-tissue sarcomas (STS) are often grouped together as they share mesenchymal origin and treatment guidelines. Also, with some exceptions, a common denominator is that when the tumor cannot be cur
Autor:
Victor Jeannot, Blaise Robin, Jean-Luc Coll, Elisabeth Brambilla, Marie Wislez, Benoit Busser, Amandine Hurbin, Jacques Cadranel
Publikováno v:
International Journal of Cancer. 134:2560-2571
To select the appropriate patients for treatment with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), it is important to gain a better understanding of the intracellular pathways leading to EGFR-TKI resistance, which is a com
Autor:
Silvio Veronese, Pierre Laurent-Puig, F. Paraf, Sandra Misale, Andrea Sartore-Bianchi, Marcella Mottolese, Salvatore Siena, Valentina Dimartino, Bart Jacobs, Cristiana Ercolani, Federica Di Nicolantonio, Emanuele Valtorta, Cornelis J. A. Punt, Alberto Bardelli, Simona Lamba, Iris D. Nagtegaal, Sebastijan Hobor, Marcello Gambacorta, Sabine Tejpar, Calogero Lauricella, Elisa Scala
Publikováno v:
International Journal of Cancer. 133:1259-1265
KRAS mutations are the most common oncogenic event in colorectal cancer (CRC) progression and their occurrence is associated with lack of response to anti epidermal growth factor receptor (EGFR) targeted therapies. Using preclinical models and patien
Autor:
Julia M. Link, Viktor Umansky, Sabine Soltek, Alexandr V. Bazhin, Jagadeesh Bayry, Ivan Shevchenko, Jens Werner, Svetlana Karakhanova
Publikováno v:
International Journal of Cancer. 133:98-107
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive human neoplasms with extremely poor prognosis and a low survival rate. Immunosuppressive cell populations, e.g. regulatory T cells (Treg), appear to be important in PDAC, contribut
Autor:
Tomi P. Mäkelä, Mira Heinonen, Alexandra Thiel, Marie-Christine Rio, Ari Ristimäki, Annabrita Hemmes, Kirsi Narko, Caj Haglund, Catherine Tomasetto
Publikováno v:
International Journal of Cancer. 131:1032-1041
Cyclooxygenase-2 (Cox-2) expression is a marker of reduced survival in gastric cancer patients, and inhibition of Cox-2 suppresses gastrointestinal carcinogenesis in experimental animal models. To investigate the role of Cox-2 in gastric carcinogenes
Autor:
Andrea Marrari, Frédérique Keslair, S. Pilotti, Elena Palassini, Paola Collini, Alessandro Gronchi, Silvia Stacchiotti, Elena Conca, Florence Pedeutour, Paolo G. Casali, Carlo Morosi, Tiziana Negri
Publikováno v:
International Journal of Cancer
International Journal of Cancer, Wiley, 2010, epub ahead of print. ⟨10.1002/ijc.25826⟩
International Journal of Cancer, Wiley, 2010, epub ahead of print. ⟨10.1002/ijc.25826⟩
Dermatofibrosarcoma Protuberans (DFSP) carries a translocation resulting in the COL1A1/PDGFB fusion-gene, responsible for platelet derived growth factor beta receptor (PDGFRB) activation. Fibrosarcomatous (FS) transformation in DFSP rarely occur. The
Autor:
Adeline Duc, Anthony Besse, Daniel Pissaloux, Angélique Gougelet, Aurélie Dutour, Jean-Yves Blay, Laurent Alberti, Jennifer Perez
Publikováno v:
International Journal of Cancer
International Journal of Cancer, Wiley, 2011, 129 (3), pp.680-690. ⟨10.1002/ijc.25715⟩
International Journal of Cancer, 2011, 129 (3), pp.680-690. ⟨10.1002/ijc.25715⟩
International Journal of Cancer, Wiley, 2011, 129 (3), pp.680-690. ⟨10.1002/ijc.25715⟩
International Journal of Cancer, 2011, 129 (3), pp.680-690. ⟨10.1002/ijc.25715⟩
Micro-RNAs (miRNA) are currently used as cancer biomarkers for hematological cancers and solid tumors. Osteosarcoma is the first primary malignant bone tumor, characterized by a complex genetic and resistance to conventional treatments. For this latt