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Autor:
K Gopalakrishnan, Sushrita Roy Muhury, Parinitha Parameshwar, Sehbanul Islam, Parul Dutta, Manas Kumar Santra, Praveenkumar Shetty, Osheen Sahay
Publikováno v:
International Journal of Cancer. 150:1512-1524
FBXO31, a member of F-box protein family, has been shown to play an important role in preventing tumorigenesis by preserving genomic stability during cell proliferations as well as upon genotoxic stresses. Inactivation of FBXO31 due to loss of hetero
Autor:
Zhiheng Pei, William J. Blot, Xiang Shu, Fen Wu, Jirong Long, Yaohua Yang, Qing Lan, Cong Wang, Qiuyin Cai, Yu Chen, Jie Wu, Nathaniel Rothman, Xiao-Ou Shu, Wei Zheng
Publikováno v:
Int J Cancer
Colonization of specific bacteria in the human mouth were reported to be associated with gastric cancer risk. However, previous studies were limited by retrospective study designs and low taxonomic resolutions. We performed a prospective case-control
Autor:
Krystle A. Lang Kuhs, Xiaowei Wang, Wade L. Thorstad, Ping Liu, Hua Li, Rebecca D. Chernock, James S. Lewis, Xinyi Liu
Publikováno v:
Int J Cancer
Increasing evidence has elucidated the clinicopathological significance of tumor microenvironment (TME) cells. However, TME differences associated with human papillomavirus (HPV) infection in oropharyngeal squamous cell carcinoma (OPSCC) have not bee
Autor:
Lucia Magnelli, Alessandra Mocali, Cristina Luceri, Katia Tortora, Lisa Giovannelli, Giovanna Caderni, Francesca Margheri, Sara Ristori
Publikováno v:
International Journal of Cancer. 150:362-373
The role of fibroblast APC mutation in carcinogenesis is not clear. Apc+/- colon fibroblasts have been previously characterized: however, little is known about their behavior at very early-stage of colon carcinogenesis. We cultured colon mucosa fibro
Autor:
Shohei Iyoshi, Kazuhisa Kitami, Keiji Kajiwara, Kae Nakamura, Shigehiro Yamaguchi, Yoshihiro Koya, Hiroaki Kajiyama, Masato Yoshihara, Sho Tano, Mai Sugiyama, Kazumasa Mogi, Hiroyuki Tomita, Kaname Uno, Masayasu Taki, Akihiro Nawa
Publikováno v:
International Journal of Cancer. 149:1961-1972
Adipocyte-rich omentum offers "good soil" for disseminating ovarian cancer (OvCa), contributing to therapeutic difficulty. However, little is understood about the association between adipocytes and tumor growth at peritoneal dissemination site. Herei
Autor:
Hongxia Ma, Xiaoxia Wei, Meng Zhu, Juncheng Dai, Rong Yin, Mengmeng Ji, Hongbing Shen, Guangfu Jin, Zhimin Ma, Lingbin Du, Zhibin Hu, Junxing Xie, Yanqian Huang, Lin Xu, Xiangxiang Jiang, Yuzhuo Wang, Chen Zhu, Jing Xu
Publikováno v:
International Journal of Cancer. 150:47-55
Chronic inflammation has been associated with the development of lung cancer. In this study, we examined the association between C-reactive protein (CRP) and lung cancer in a prospective cohort study and used Mendelian randomization (MR) to clarify t
Publikováno v:
International Journal of Cancer. 150:18-27
H. pylori (H. pylori) infection is considered the leading cause of gastric cancer. Gastric cancer is currently a common cancer with high incidence and mortality rates, but it is expected that the incidence rate will gradually decrease as the H. pylor
Autor:
Lu Gao, Weiyang Mi, Wei Dai, Shiwen Guo, Ning Wang, Hangyu Shi, Pengfei Hou, Tianbo Jin, Lin Wei, Yongzhi Shi, Gang Zhang, Yongqiang Shi, Nan Li
Publikováno v:
International Journal of Cancer. 149:1910-1915
Glioma is a common and fatal primary malignant tumor of the central nervous system, and its prognosis is poor. To determine the susceptibility markers of gliomas in Chinese population we conducted a genome-wide association study (GWAS) of glioma in t
Autor:
Thomas Kindler, Sebastian Boegel, Sebastian Rosigkeit, Marie Kruchem, Ernesto Bockamp, Patricia Haehnel, Udo F. Hartwig, Geethanjali Pickert, Sandrine Jansky, Mariano Barbacid, Detlef Schuppan, Dorothe Thies, Carmen Guerra, Andreas Kreft, Leonard Kaps, Emma Eichler, Dominik Siegl
Publikováno v:
International Journal of Cancer. 149:1670-1682
Accumulating evidence suggests that both the nature of oncogenic lesions and the cell-of-origin can strongly influence cancer histopathology, tumor aggressiveness and response to therapy. Although oncogenic Kras expression and loss of Trp53 tumor sup
Autor:
Wim Quint, Alexander Kreuter, Jan M. Prins, Renske D.M. Steenbergen, Henry J. C. de Vries, Chris J.L.M. Meijer, Ramon P. van der Zee, Miekel M. van de Sandt, Tamzin Cuming
Publikováno v:
International Journal of Cancer. 149:1833-1844
Human papillomavirus (HPV)-induced anal intraepithelial neoplasia (AIN, graded 1-3) is highly prevalent in HIV-positive (HIV+) men who have sex with men (MSM), but only a minority of lesions progresses to cancer. Our study aimed to characterise compr