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Publikováno v:
International Immunopharmacology
Exposure to viral or bacterial pathogens increases the number of neutrophils with a relative decrease in lymphocytes, leading to elevated neutrophil to lymphocyte ratio (NLR). This study aimed to investigate whether differences in NLR among real-time
Publikováno v:
International Immunopharmacology
BACKGROUND: Vaccination is crucial to limit the pandemic spread of SARS-CoV-2/COVID-19. Therefore, besides the development and supply of vaccines, it is essential that sufficient individuals are willing to get vaccinated, but concerning proportions o
Autor:
Negin Allahyari, Saeed Eslami Hasan Abadi, Arezoo Akbarian, Mahnaz Amini, Alireza Bari, Sepideh Hasanzadeh, Sajad Ataei Azimi, Maryam Emadzadeh, Neda Saeedian, Mohammad Moeini Nodeh, Zahra Javidarabshahi, Hossein Rahimi, Mojtaba Abrishami, Mostafa Kamandi, Parisa Ataei, Mohsen Seddigh-Shamsi, Zahra Mozaheb, Alireza Sedaghat, Abolghasem Allahyari, Mahnaz Mozdourian, Mahmoud Mahmoudi, Shahram Amini, Saeid Amel Jamehdar
Publikováno v:
International Immunopharmacology
Highlights • Convalescent plasma (CP) improves outcomes and decrease mortality rate in COVID-19. • CP seems to be most beneficial for treating severe COVID-19 with mild ARDS. • Early administration of CP could contribute to the treatment of sev
Publikováno v:
International Immunopharmacology
To accumulate evidence that indicated the key role played by virus-triggered inflammation in the 2019-novel coronavirus disease (COVID-19) which emerged in Wuhan City and rapidly spread throughout China.Age, neutrophil(NEU)-to-lymphocyte (LYM) ratio
Autor:
Seyed Mohammadreza Hashemian, Jalal Heshmatnia, Mihan Pourabdollah Toutkaboni, Payam Tabarsi, Sahar Yousefian, Sara Haseli, Farzaneh Dastan, Hamidreza Jammati, Alireza Dastan, Mohsen Sadeghi, Arda Kiani, Ali Saffaei, Parvaneh Baghaei, Jamshid Salamzadeh, Mohammad Varahram, Zahra Abtahian, Seyed Alireza Nadji, Sharareh Seifi, Alireza Eslaminejad, Majid Marjani, Afshin Moniri, Atefeh Abedini
Publikováno v:
International Immunopharmacology
Highlights • The pathophysiology of severe SARS-CoV-2 infection may be attributed to cytokine release syndrome. • In this syndrome, inflammatory cytokines (especially interleukin 6) are released after the activation of the inflammatory cascade.
Publikováno v:
International Immunopharmacology
Highlights • NCD4LR will contribute to the prediction of NCT in COVID-19 patients. • Patients in the high NCD4LR group had a longer NCT. • NCD4LR show better predictive value than NLR in predicting NCT. • NCD4LR is a potential biomarker for c
Autor:
Noemí Ruiz-de-Lobera, Judith Anton-Remirez, Valentín Lisa Catón, Ricardo García-Muñoz, Giovanna Farfán-Quiroga, Jesus Feliu, José Antonio Oteo-Revuelta, Maria José Nájera Irazu
Publikováno v:
International Immunopharmacology
SARS-CoV-2 infection can be a life-threatening disease. The optimal treatment of patients is not yet standardized. We use a serology-based therapeutic strategy based on the presence of antibodies against the SARS-CoV-2 virus, in which patients with p
Autor:
Janeusa Trindade de Souto, Alessandra Peres, Paulo Cesar de Santana Filho, Pedro R. T. Romão, Isabelle Agostinho de Lima Postiga, Gilson Pires Dorneles, Simone G. Fonseca, Paula Teixeira, Luiz Carlos Rodrigues Junior, Liane Nanci Rotta, Claudia Elizabeth Thompson, Sarah Eller, Carla Andretta Moreira Neves, Igor Martins da Silva, Lucas de Lima Schipper, Tiago Franco de Oliveira
Publikováno v:
International Immunopharmacology
Graphical abstract
Mucosal barrier alterations may play a role in the pathogenesis of several diseases, including COVID-19. In this study we evaluate the association between bacterial translocation markers and systemic inflammation at the earlie
Mucosal barrier alterations may play a role in the pathogenesis of several diseases, including COVID-19. In this study we evaluate the association between bacterial translocation markers and systemic inflammation at the earlie
Autor:
Alireza Dastan, Sahar Yousefian, Saghar Barati, Zahra Abtahian, Ali Sobhanian, Payam Tabarsi, Seyed Mohammadreza Hashemian, Sara Haseli, Atefeh Abedini, Mahshid Ashrafzadeh, Farzaneh Dastan
Publikováno v:
International Immunopharmacology
Background Regarding the COVID-19 pandemic, potential therapeutic agents are being evaluated almost every day. Ciclosporin, a calcineurin inhibitor, is characterized by beneficial antiviral and immunomodulatory effects. The present study aimed to eva
Autor:
Negar Khalili, Mohamad Amin Pourhoseingholi, Ilad Alavi Darazam, Azam Soleymaninia, Latif Gachkar, Akram Hoseyni Kusha, Mohammad Mahdi Rabiei, Minoosh Shabani, Legha Lotfollahi, Mahdi Amirdosara, Firouze Hatami, Parham Torabinavid, Omid Moradi, Mohammadreza Hajiesmaeili, Ali Khoshkar, Masoud Mardani, Hadiseh Shabanpour Dehbsneh, Maryam Taleb Shoushtari, Omidvar Rezaei, Seyed Sina Naghibi Irvani, Shervin Shokouhi, Farid Javandoust Gharehbagh
Publikováno v:
International Immunopharmacology
Introduction The effectiveness of umifenovir against COVID-19 is controversial; therefore, clinical trials are crucial to evaluate its efficacy. Methods The study was conducted as a single-center, randomized, open-label clinical trial. Eligible moder