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Autor:
Andrew J. Gow, Melissa L. Wilkinson
Publikováno v:
Innate Immunity
Innate Immunity, Vol 27 (2021)
Innate Immunity, Vol 27 (2021)
Fatty acid nitroalkenes are reversibly-reactive electrophiles that are endogenously detectable at nM concentrations and display anti-inflammatory, pro-survival actions. These actions are elicited through the alteration of signal transduction proteins
Publikováno v:
Innate Immunity
Innate Immunity, Vol 27 (2021)
Innate Immunity, Vol 27 (2021)
miR-150 was found to target the 3′-untranslated regions of AKT3, and the AKT pathway was affected by SR protein kinase 1 (SRPK1). However, the expression and significance of miR-150, AKT3 and SRPK1 in acute lung injury (ALI) were not clear. Here, w
Publikováno v:
Innate Immunity
The aim of this study was to explore the effects of ethanol extracts from Portulaca oleracea L. (ePO) on joint inflammation and to explain the underlying mechanisms. A joint inflammation mouse model was constructed by injecting zymosan, and the Von F
Publikováno v:
Innate Immunity
Innate Immunity, Vol 26 (2020)
Innate Immunity, Vol 26 (2020)
This study aimed to explore comprehensively the biological function of curcumin, and its underlying mechanism, in protecting from necrotising microscopic colitis in newborn rats. A total of 20 normal healthy rats were selected, and a necrotising ente
Publikováno v:
Innate Immunity
Innate Immunity, Vol 27 (2021)
Innate Immunity, Vol 27 (2021)
Compromised TLR-mediated chronic inflammation contributes to bacterial infection-caused chronic suppurative otitis media, but the mechanisms are unclear. The present study examined the expression status of nuclear erythroid 2-related factor 2 (Nrf2)
Publikováno v:
Innate Immunity
Innate Immunity, Vol 26 (2020)
Innate Immunity, Vol 26 (2020)
Allergic rhinitis (AR) is a nasal mucosal inflammatory disease mediated by environmental allergens. At present, the relationship between the IL-33/ST2 axis, ERK1/2 pathway and AR progression needs further exploration. In our study, an AR model was co
Autor:
W.Y.C. Lai, Yajing Wang, Kari Ann Shirey, Lindsey J. Brown, Greg A. Snyder, Robert Beadenkopf, Jorge C. G. Blanco, Stefanie N. Vogel
Publikováno v:
Innate Immunity
Innate Immunity, Vol 26 (2020)
Innate Immunity, Vol 26 (2020)
TLRs are a family of PRRs that respond to PAMPs or host-derived Danger-Associated Molecular Patterns (DAMPs) to initiate host inflammation and immune responses. TLR dimerization and recruitment of adapter molecules is critical for intracellular signa
Publikováno v:
Innate Immunity
Innate Immunity, Vol 26 (2020)
Innate Immunity, Vol 26 (2020)
This study aimed to examine whether stromal cell-derived factor-1 (SDF-1) or C-X-C chemokine ligand 12 (CXCL12) participates in the development of lumbar disc degeneration, as implicated earlier by the level of CXCL12 correlating with this disease. I
Autor:
Yujun Xian, Yingchun Zhang, Yujiao Luo, Jiajia Liu, Yu Liang, Chengcheng He, Bo Luo, Jingyuan Zeng, Nan Jiang, Hongwei Luo, Xiaoli Zheng, Yancheng He
Publikováno v:
Innate Immunity, Vol 26 (2020)
Innate Immunity
Innate Immunity
Polymorphonuclear neutrophils (PMNs) are the most important determinants in the acute inflammatory response. Pathologically increased numbers of PMNs in the circulation or specific tissues (or both) lead to neutrophilia. However, the genes expressed
Publikováno v:
Innate Immunity, Vol 27 (2021)
Innate Immunity
Innate Immunity
COVID-19 is both a viral illness and a disease of immunopathology. Proximal events within the innate immune system drive the balance between deleterious inflammation and viral clearance. We hypothesize that a divergence between the generation of exce