Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Jack Satsangi"'
Autor:
Philip Jenkinson, Mrithula Shivakumar, Gareth-Rhys Jones, Ian D. Arnott, R Grant, Jack Satsangi, Charlie W. Lees, Ruairi Lynch, Nikolas Plevris, F Jagger, William M Brindle, Thomas Manship
Publikováno v:
Inflammatory Bowel Diseases. 27:451-457
Background Intravenous (IV) steroids remain the first-line treatment for patients with acute ulcerative colitis (UC). However, 30% of patients do not respond to steroids, requiring second-line therapy and/or surgery. There are no existing indices tha
Publikováno v:
Inflammatory bowel diseases. 26(11)
The intestinal mucosa represents a unique environment where the coordinated function of diverse epithelial, mesenchymal, and immune cells maintains a physiologically balanced environment in the presence of gut microbiota. The intestinal mucosa plays
Autor:
Jack Satsangi, Sreedhar Subramanian, Steven W. Edwards, Direkrit Chiewchengchol, Barry J. Campbell, Jonathan M. Rhodes, Helen L. Wright, Paul K Flanagan, Abdullah Alswied
Publikováno v:
Inflammatory Bowel Diseases
Flanagan, P K, Chiewchengchol, D, Wright, H L, Edwards, S W, Alswied, A, Satsangi, J, Subramanian, S, Rhodes, J M & Campbell, B J 2015, ' Killing of Escherichia coli by Crohn's Disease Monocyte-derived Macrophages and Its Enhancement by Hydroxychloroquine and Vitamin D ', Inflammatory Bowel Diseases, vol. 21, no. 7, pp. 1499-510 . https://doi.org/10.1097/MIB.0000000000000387
Flanagan, P K, Chiewchengchol, D, Wright, H L, Edwards, S W, Alswied, A, Satsangi, J, Subramanian, S, Rhodes, J M & Campbell, B J 2015, ' Killing of Escherichia coli by Crohn's Disease Monocyte-derived Macrophages and Its Enhancement by Hydroxychloroquine and Vitamin D ', Inflammatory Bowel Diseases, vol. 21, no. 7, pp. 1499-510 . https://doi.org/10.1097/MIB.0000000000000387
Article first published online 1 April 2015. Supplemental Digital Content is Available in the Text.
Background: Crohn's disease (CD) is associated with defective innate immunity, including impaired neutrophil chemotaxis, and mucosal invasion by
Background: Crohn's disease (CD) is associated with defective innate immunity, including impaired neutrophil chemotaxis, and mucosal invasion by
Autor:
Ulla Vogel, Anja Ernst, Jack Satsangi, Mette Østergaard, Bent Ascanius Jacobsen, Gwo-Tzer Ho, Charlie W. Lees, Jane Christensen, Elaine R. Nimmo, Henrik Krarup, Vibeke Andersen, Hazel E. Drummond
Publikováno v:
Andersen, V, Nimmo, E, Krarup, H B, Drummond, H, Christensen, J, Ho, G, Ostergaard, M, Ernst, A, Lees, C, Jacobsen, B A, Satsangi, J & Vogel, U 2011, ' Cyclooxygenase-2 (COX-2) Polymorphisms and Risk of Inflammatory Bowel Disease in a Scottish and Danish Case-Control Study ', Inflammatory Bowel Diseases, vol. 17, no. 4, pp. 937-46 . https://doi.org/10.1002/ibd.21440
Andersen, V, Nimmo, E, Krarup, H B, Drummond, H, Christensen, J, Ho, G-T, Ostergaard, M, Ernst, A, Lees, C, Jacobsen, B A, Satsangi, J & Vogel, U B 2011, ' Cyclooxygenase-2 (COX-2) polymorphisms and risk of inflammatory bowel disease in a Scottish and Danish case-control study ', Inflammatory Bowel Diseases, vol. 17, no. 4, pp. 937-946 . https://doi.org/10.1002/ibd.21440
Andersen, V, Nimmo, E, Krarup, H B, Drummond, H, Christensen, J, Ho, G-T, Ostergaard, M, Ernst, A, Lees, C, Jacobsen, B A, Satsangi, J & Vogel, U B 2011, ' Cyclooxygenase-2 (COX-2) polymorphisms and risk of inflammatory bowel disease in a Scottish and Danish case-control study ', Inflammatory Bowel Diseases, vol. 17, no. 4, pp. 937-946 . https://doi.org/10.1002/ibd.21440
Background: Inflammatory bowel diseases (IBDs) are a result of interactions between luminal pathogens and the intestinal immune response. Cyclooxygenase-2 (COX-2) plays a key role in the regulation of the inflammatory response upon stimulation by lum
Autor:
Zora Modrusan, Hilary Clark, Jack Satsangi, Ian D. Penman, Ian D. Arnott, Jennine Cornelius, Charlie W. Lees, Karen Toy, Lauri Diehl, Alexander R. Abbas, Colin L. Noble
Publikováno v:
Inflammatory Bowel Diseases. 16:1717-1728
Background: Genome-wide microarray expression analysis creates a comprehensive picture of gene expression at the cellular level. The aim of this study was to investigate differential intestinal gene expression in patients with Crohn's disease (CD) an
Autor:
Constantinos A. Parisinos, Jack Satsangi, Charlie W. Lees, S Glancy, I. D. R. Arnott, V. E. D. McIntyre, David C. Wilson, Craig Mowat, S. McGurk, I. A. Zealley, Tim Heron, D. Subedi
Publikováno v:
Inflammatory Bowel Diseases. 16:1219-1226
Background: Magnetic resonance follow-through (MRFT) is a new cross-sectional imaging modality with the potential to accurately stage ileal Crohn's disease (CD), while avoiding ionizing radiation and the discomfort associated with enteroclysis. We ai
Autor:
G. Davies, Elaine R. Nimmo, Paraic McGrogan, Jack Satsangi, W M Bisset, Gamal Mahdi, Lawrence T. Weaver, Richard K Russell, Linda Smith, Hazel E. Drummond, I. D. R. Arnott, David C. Wilson, Niall Anderson, Peter M. Gillett, J. van Limbergen
Publikováno v:
Inflammatory Bowel Diseases. 14:338-346
The rs2241880A/G variant of the ATG16L1 gene has been associated with susceptibility to ileal Crohn's disease (CD) in adults. Our aim was to assess whether germline variation of ATG16L1 acts as an independent determinant of susceptibility to childhoo
Autor:
Jack Satsangi, Gwo-Tzer Ho, Ian D. Arnott, Richard K Russell, Elaine R. Nimmo, Johan Van Limbergen, David C. Wilson
Publikováno v:
Inflammatory Bowel Diseases. 13:338-355
The discovery of nucleotide-binding oligomerization domain 2/caspase recruitment domain-containing protein 15 (NOD2/CARD15) as the first susceptibility gene in Crohn's disease (CD) has shifted the focus of research into the pathogenesis of inflammato
Autor:
David C. Wilson, Jack Satsangi, Nicholas A. Kennedy, Richard K Russell, FL Cameron, Paul Henderson, Johan Van Limbergen
Publikováno v:
Inflammatory bowel diseases. 21(3)
BACKGROUND C-reactive protein (CRP) is an acute phase reactant. Patients with pediatric inflammatory bowel disease (PIBD) differ from adult patients with inflammatory bowel disease with regard to phenotype, inflammatory profile, and treatment respons
Publikováno v:
Inflammatory Bowel Diseases. 11:1013-1019
The chronic idiopathic inflammatory bowel diseases (IBDs), Crohn’s disease (CD) and ulcerative colitis (UC), are characterized by an overly aggressive cell-mediated immune response to luminal commensal bacteria in genetically susceptible individual