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Publikováno v:
Inflammatory Bowel Diseases
Background Clinical indices to characterize the severity of inflammatory bowel disease (IBD) are widely used in clinical trials and real-world practice. However, there are few validated instruments for assessing IBD severity in administrative claims-
Autor:
Michael Gizis, Ioannis Papakonstantinou, George Kolios, Ioannis Koutsounas, Ioannis Varbobitis, Giorgos Bamias, G Kokkotis, Despoina Bekiari, Georgios Kounadis, Vassileios Xourafas, Nikoletta Perlepe, Stilliani Lagou, Maria Bletsa, Efrosini Laoudi
Publikováno v:
Inflammatory Bowel Diseases. 27:826-835
Background Fatigue is highly prevalent among patients with inflammatory bowel disease (IBD) and may have an unfavorable impact on quality of life (QoL). The IBD-Fatigue scale (with components SCORE1 and SCORE2) is a recently developed disease-specifi
Autor:
Takuya Ishikawa, Kentaro Murate, Mitsuhiro Fujishiro, Daisuke Sugiyama, Masanao Nakamura, Ryoji Miyahara, Yasuyuki Mizutani, Hiroki Kawashima, Masatoshi Ishigami, Eizaburo Ohno, Keiko Maeda, Hirotaka Wada, Takeshi Yamamura, Takashi Honda, Tsunaki Sawada, Kazuhiro Furukawa, Hiroyoshi Nishikawa
Publikováno v:
Inflammatory Bowel Diseases. 26:1669-1681
Background and Aims The therapeutic efficacy and safety of ustekinumab for Crohn’s disease (CD) have been reported from randomized controlled trials and real-world data. However, there are few studies describing the identification of patients most
Autor:
Annette Wilson, David G. Binion, Dmitriy Babichenko, Janet Harrison, Gong Tang, Xiaoqing Tan, Elyse Johnston, Siobhan Proksell, Krishnapriya Marangattu Prathapan, Arthur Barrie, Sandra C. Kim, Michael A. Dunn, Filippos Koutroumpakis, Jana G. Hashash, Claudia Ramos Rivers, Ioannis E. Koutroubakis, Alyce Anderson, Marc Schwartz, Douglas J. Hartman
Publikováno v:
Inflammatory Bowel Diseases. 26:1890-1900
Background Peripheral blood eosinophilia (PBE) is a biomarker of an aggressive multiyear natural history in adults with inflammatory bowel diseases (IBDs). Additionally, PBE at diagnosis is associated with higher disease activity in pediatric-onset I
Autor:
Ioannis E. Koutroubakis, Janet Harrison, Jana G. Hashash, Gong Tang, Siobhan Proksell, Hassieb Din, Arthur Barrie, David G. Binion, Elyse Johnston, Marc Schwartz, Tariq Salim, Douglas J. Hartman, Dmitriy Babichenko, Michael A. Dunn, Alyce J. Anderson, Claudia Ramos Rivers, Filippos Koutroumpakis
Publikováno v:
Inflammatory Bowel Diseases. 26:1436-1442
Background Given the rising prevalence of diabetes mellitus (DM) and the limited data on its effect on the course of inflammatory bowel disease (IBD), we characterized multiyear patterns of disease severity in a cohort of IBD patients with coexistent
Autor:
Cátia Rocha, Pedro Pinto-Lopes, Fernando Magro, Paula Lago, Joana Afonso, Rui Pinto-Lopes, Cláudia Camila Dias, Guilherme Macedo, Raquel Gonçalves, Helena Sousa
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
© 2020 Crohn’s & Colitis Foundation. Published by Oxford University Press. All rights reserved. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model.
A correction has be
A correction has be
Autor:
Maria K. Magnusson, Luiza Moraes, Georgios Mavroudis, Hans Törnblom, Magnus Simren, Börje Jonefjäll, Annikka V. Polster, Hans Strid, Lena Öhman, Johanna Sundin
Publikováno v:
Inflammatory Bowel Diseases
This study investigated immune profiles of ulcerative colitis (UC) patients and irritable bowel syndrome (IBS) patients and healthy individuals and showed that inflammatory mechanisms leading to IBS-like symptoms in UC may be different from the mecha
Autor:
Callum Dargavel, David Kevans, Mark S. Silverberg, Richard Kirsch, Boyko Kabakchiev, Robert H. Riddell
Publikováno v:
Inflamm Bowel Dis
Background In ulcerative colitis (UC) patients who have achieved mucosal healing, active microscopic colonic mucosal inflammation is commonly observed. We aimed to assess the association between histological activity and disease relapse in endoscopic
Autor:
Leonardo Salese, Danielle Bargo, Daniel Quirk, Millie D. Long, David Gruben, Timothy W. Smith, Marco DiBonaventura
Publikováno v:
Inflammatory Bowel Diseases
In this real-world analysis, patients with ulcerative colitis frequently required steroids up to a year after initiating immunosuppressant or biologic therapies, with high ulcerative colitis-related costs. This suggests an ongoing challenge in managi
Autor:
Matthew A. Ciorba, Xueyan Guo, Felicia D. Allard, Elisabeth M. Davis, Sarah C. Glover, Eric U. Yee, Bo Shen, Brian Claggett, Bincy Abraham, Mark T. Osterman, Freeha Khan, Ilyssa O. Gordon, Julia J. Liu
Publikováno v:
Inflammatory Bowel Diseases. 26:1554-1561
Objective Mucosal barrier dysfunction plays a crucial role in intestinal inflammation in Crohn’s disease (CD). Intestinal epithelial cell (IEC) death resulting from innate immune activation, termed pyroptosis, was recently found to be a cause of th