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Autor:
Andres Yarur, Freddy Caldera, Sirimon O'Charoen, Joshua R. Korzenik, Cecile Norris, Matthew Bohm, Monika Fischer, Sara Sweeney, Alandra Weaver, Uni Wong, Sushila Dalal, Themistocles Dassopoulos, Katerina Wells, David Hudesman, Lilani P. Perera, Shrinivas Bishu, Caren Heller, Richard H. Duerr, Tara Fehlmann, Deepak Parakkal, Raymond K. Cross, James D. Lewis, Manreet Kaur, Matthew A. Ciorba, Sumona Saha, Elizabeth A. Scoville, Laura E. Raffals, Joel Pekow, Scott B. Snapper, Angela Dobes, Meenakshi Bewtra
Publikováno v:
Inflamm Bowel Dis
Background Clinical and molecular subcategories of inflammatory bowel disease (IBD) are needed to discover mechanisms of disease and predictors of response and disease relapse. We aimed to develop a study of a prospective adult research cohort with I
Autor:
Mitra Barahimi, Jason Harper, Anand Singla, Scott D. Lee, Kindra Clark-Snustad, Kendra Kamp, Jeffrey Jacobs
Publikováno v:
Inflamm Bowel Dis
Background The majority of patients with Crohn’s disease (CD) will not achieve endoscopic remission on current therapy. Addition of tofacitinib to biologics may improve remission rates. Methods We retrospectively assessed safety and clinical and en
Autor:
Hyuk Yoon, Sushrut Jangi, Brian G. Feagan, Brigid S. Boland, William J. Sandborn, Parambir S. Dulai, Siddharth Singh, Vipul Jairath
Publikováno v:
Inflamm Bowel Dis
Background Although achieving histologic remission in ulcerative colitis is established, the incremental benefit of achieving histologic remission in patients with Crohn disease (CD) treated to a target of endoscopic remission is unclear. We evaluate
Autor:
Arne K. Sandvik, Maya Olaisen, Elin Synnøve Røyset, Reidar Fossmark, Arnar Flatberg, Atle van Beelen Granlund, Tom C. Martinsen
Publikováno v:
Inflammatory Bowel Diseases
Background Microbiota is most likely essential in the pathogenesis of Crohn’s disease (CD). Fecal diversion after ileocecal resection (ICR) protects against CD recurrence, whereas infusion of fecal content triggers inflammation. After ICR, the majo
Autor:
Annette Wilson, David G. Binion, Dmitriy Babichenko, Janet Harrison, Gong Tang, Xiaoqing Tan, Elyse Johnston, Siobhan Proksell, Krishnapriya Marangattu Prathapan, Arthur Barrie, Sandra C. Kim, Michael A. Dunn, Filippos Koutroumpakis, Jana G. Hashash, Claudia Ramos Rivers, Ioannis E. Koutroubakis, Alyce Anderson, Marc Schwartz, Douglas J. Hartman
Publikováno v:
Inflammatory Bowel Diseases. 26:1890-1900
Background Peripheral blood eosinophilia (PBE) is a biomarker of an aggressive multiyear natural history in adults with inflammatory bowel diseases (IBDs). Additionally, PBE at diagnosis is associated with higher disease activity in pediatric-onset I
Autor:
Callum Dargavel, David Kevans, Mark S. Silverberg, Richard Kirsch, Boyko Kabakchiev, Robert H. Riddell
Publikováno v:
Inflamm Bowel Dis
Background In ulcerative colitis (UC) patients who have achieved mucosal healing, active microscopic colonic mucosal inflammation is commonly observed. We aimed to assess the association between histological activity and disease relapse in endoscopic
Autor:
Lianne Koens, Jojanneke E van Amesfoort, Willem A. Bemelman, Christianne J. Buskens, Maurits L. van Montfoort, Karin A. T. G. M. Wasmann
Publikováno v:
Inflammatory bowel diseases, 26(11), 1691-1699. John Wiley and Sons Inc.
Background Resections for Crohn’s disease should be limited and only resect macroscopically affected bowel. However, recent studies suggest microscopic inflammation at resection margins as a predictor for postoperative recurrence. The clinical impa
Autor:
Sarah Lopatin, Benjamin L. Cohen, Ryan C. Ungaro, Bruce E. Sands, Jean-Frederic Colombel, Daniel Castaneda, Robert Hirten
Publikováno v:
Inflamm Bowel Dis
Background Crohn’s disease recurrence after ileocolic resection is common and graded with the Rutgeerts score. There is controversy whether anastomotic ulcers represent disease recurrence and should be included in the grading system. The aim of thi
Autor:
Matthew A. Ciorba, Xueyan Guo, Felicia D. Allard, Elisabeth M. Davis, Sarah C. Glover, Eric U. Yee, Bo Shen, Brian Claggett, Bincy Abraham, Mark T. Osterman, Freeha Khan, Ilyssa O. Gordon, Julia J. Liu
Publikováno v:
Inflammatory Bowel Diseases. 26:1554-1561
Objective Mucosal barrier dysfunction plays a crucial role in intestinal inflammation in Crohn’s disease (CD). Intestinal epithelial cell (IEC) death resulting from innate immune activation, termed pyroptosis, was recently found to be a cause of th
Publikováno v:
Inflammatory Bowel Diseases
First detected in Wuhan, China, the novel 2019 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped RNA beta-coronavirus responsible for an unprecedented, worldwide pandemic caused by COVID-19. Optimal management of immunosupp