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Autor:
Debojyoti Moulick, Anupom Borah, Shuvasish Choudhury, Muhammed Khairujjaman Mazumder, Purbajyoti Saikia
Publikováno v:
In Silico Pharmacology
Severe Acute Respiratory Syndrome coronavirus (SARS-CoV), Middle East Respiratory Syndrome coronavirus (MERS-CoV) and the novel SARS-CoV-2 evade the host innate immunity, and subsequently the adaptive immune response, employing one protease called Pa
Publikováno v:
In Silico Pharmacology. 9
Cannabis sativa L. Cannabaceae, used for psychoactive rituals in Mesopotamia. Here, we investigated in vitro inhibitory activity of methyl alcohol extract derived from leaves and resin of cannabis against acetylcholinesterase (AChE) and butyrylcholin
Publikováno v:
In Silico Pharmacology. 9
P-glycoprotein (P-gp), which was first identified in cancer cells, is an ATP-dependent efflux transporter that expels a wide variety of cytotoxic compounds out of cells. This transporter can decrease the bioavailability of therapeutic drugs by preven
Autor:
Reza Nejat, Ahmad Shahir Sadr
Publikováno v:
In Silico Pharmacology
Proposing a theory about the pathophysiology of cytokine storm in COVID19, we were to find the potential drugs to treat this disease and to find any effect of these drugs on the virus infectivity through an in silico study. COVID-19-induced ARDS is l
Publikováno v:
In Silico Pharmacol
Hypertension is a public health concern. Low dose thiazide diuretics are known to effectively control blood pressure compared to that of other classes of antihypertensive drugs. In this context, we have performed an in-silico study and found that the
Autor:
Tareq Mahmud, Monir Uzzaman
Publikováno v:
In Silico Pharmacol
Aspirin (Asp) is one of the most important and ancient member of nonsteroidal anti-inflammatory drugs (NSAID), commonly used in medication of fever, pain and inflammation. It can inhibit the synthesis of prostaglandin by blocking the cyclooxygenase (
Autor:
Sayantan Pradhan, Chittaranjan Sinha
Publikováno v:
In Silico Pharmacology. 6
Both DHPS (dihydropteroate synthase) and DHFR (dihydrofolate reductase) play important physiological roles in the survivability of Mycobacterium tuberculosis (MTB). Sulfonamides are the potent drugs to monitor growth and proliferation of MTBs by inhi
Autor:
Tabish Qidwai
Publikováno v:
In Silico Pharmacology. 5
Development of resistance in the Plasmodium falciparum to Artemisinin, the most effective anti-malarial compound, threatens malaria elimination tactics. To gain more efficacious Artemisinin derivatives, QSAR modeling and docking was performed. In the
Publikováno v:
In Silico Pharmacology
Purpose Angiogenesis, or new blood vessel formation from existing one, plays both beneficial and detrimental roles in living organisms in different aspects. Vascular endothelial growth factor (VEGF), a signal protein, well established as key regulato