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Autor:
Kenneth Hsu, Nicodemus Tedla, Sharron Chow, Naomi Kawaguchi, Sze Wing Wong, Yuka Hiroshima, Carolyn L. Geczy
Publikováno v:
Immunology and Cell Biology
S100A8 and S100A9 are myeloid cell-derived proteins that are elevated in several types of inflammatory lung disorders. Pro- and anti-inflammatory properties are reported and these proteins are proposed to activate TLR4. S100A8 and S100A9 can function
Autor:
Hisaaki Shinohara, Tomohiro Kurosaki
Publikováno v:
Immunology and Cell Biology
The transcription factor nuclear factor-κB (NF-κB) signaling pathway is crucial in B-cell physiology. One key molecule regulating this pathway is the serine/threonine kinase TAK1 (MAP3K7). TAK1 is responsible for positive feedback mechanisms in B-c
Controversies concerning thymus-derived regulatory T cells: fundamental issues and a new perspective
Autor:
Masahiro Ono, Reiko J. Tanaka
Publikováno v:
Immunology and Cell Biology
Thymus-derived regulatory T cells (Tregs) are considered to be a distinct T-cell lineage that is genetically programmed and specialised for immunosuppression. This perspective is based on the key evidence that CD25(+) Tregs emigrate to neonatal splee