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Publikováno v:
Immunol Cell Biol
The immune system defends the body from infectious and non-infectious threats. Distinct recognition strategies have evolved to generate antigen-specific immunity against pathogens or toxins versus antigen-independent tissue repair. Structural recogni
Publikováno v:
Immunology and Cell Biology
Immune monitoring enables a better understanding of disease processes and response to therapy, but has been challenging in the setting of chronic autoimmunity because of unknown etiology, variable and protracted kinetics of the disease process, heter
Publikováno v:
Immunology & Cell Biology. 98:626-638
Psoriasis (PS) and atopic dermatitis (AD) are common inflammatory skin diseases characterized by an imbalance in specific T-cell subsets, resulting in a specific cytokine profile in patients. Obtaining models closely resembling both pathologies along
Publikováno v:
Immunology & Cell Biology. 98:467-479
Primary immune deficiency is caused by genetic mutations that result in immune dysfunction and subsequent susceptibility to infection. Over the last decade there has been a dramatic increase in the number of genetically defined causes of immune defic
Publikováno v:
Immunology & Cell Biology. 98:264-275
Many parasitic infections stimulate antibody responses in their mammalian hosts. The ability of these antibodies to protect against disease varies markedly. Research has revealed that functional properties of antibodies determine their role in protec
Autor:
Lingwen Gu, Qian Wang, Cui Li, Yiqun Fan, Chunli Lu, Yawen Niu, Guoqiang Zhu, Hao Lin, Xudong Peng, Jing Lin, Guiqiu Zhao
Publikováno v:
Immunology and Cell Biology
Dimethyl itaconate (DI) is a membrane‐permeable itaconate derivative with anti‐inflammatory functions. However, the anti‐inflammatory effect of DI has never been studied in fungal keratitis. In this study, we tested the protective effect of DI
Publikováno v:
Immunology & cell biology 98(1), 28-41 (2019). doi:10.1111/imcb.12301
Alzheimer's disease (AD) is characterized by amyloid beta (Aβ) accumulation, tau pathology and neuroinflammation. Recently, there has been considerable interest in the role of neuroinflammation in directly contributing to the progression of AD. Stud
Autor:
Susanne Tritscheller, William John Martin, Jeremy M Raynes, Natalie Lorenz, Timothy Kc Ho, Nigel Wilson, Mei Lin Tay, Alana L. Whitcombe, Amy W. Chung, Reuben McGregor, Nicole J. Moreland, Michael G Baker, Jason Gurney, Deborah A Williamson, Paulina Hanson-Manful, Cristin G. Print, Jane Oliver
Publikováno v:
Immunology & Cell Biology. 98:12-21
Acute rheumatic fever (ARF) and chronic rheumatic heart disease (RHD) are autoimmune sequelae of a Group A streptococcal infection with significant global mortality and poorly understood pathogenesis. Immunoglobulin and complement deposition were obs
Autor:
Kun-Hui Lu, Shom Goel
Publikováno v:
Nature
Cancer arises from malignant cancer cells in dynamic multilevel interactions with the host tissue. Cancer therapies aiming to directly destruct cancer cells including oncogene-targeted therapy and immune checkpoint therapy that revives tumor-reactive
Autor:
James A. Triccas, Claudio Counoupas
Publikováno v:
Immunology & Cell Biology. 97:656-663
Tuberculosis (TB) kills more individuals each year than any other single pathogen and a more effective vaccine is critical for the global control of the disease. Although there has been recent progress in the clinical testing of candidates, no new va