Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Shimon, Sakaguchi"'
Publikováno v:
Immunity. 50:302-316
Regulatory T (Treg) cells expressing the transcription factor Foxp3 have a critical role in the maintenance of immune homeostasis and prevention of autoimmunity. Recent advances in single cell analyses have revealed a range of Treg cell activation an
Autor:
Yohko Kitagawa, Keiko Yasuda, Norihisa Mikami, Masaya Arai, Hitomi Watanabe, Kelvin Y. Chen, Gen Kondoh, Daiya Ohara, Motonao Osaki, Yamami Nakamura, Keiji Hirota, Naganari Ohkura, Shimon Sakaguchi, Ryoji Kawakami, Caleb A. Lareau
Publikováno v:
Immunity. 54(5)
The transcription factor Foxp3 plays crucial roles for Treg cell development and function. Conserved non-coding sequences (CNSs) at the Foxp3 locus control Foxp3 transcription, but how they developmentally contribute to Treg cell lineage specificatio
Publikováno v:
Immunity. 50(2)
Regulatory T (Treg) cells expressing the transcription factor Foxp3 have a critical role in the maintenance of immune homeostasis and prevention of autoimmunity. Recent advances in single cell analyses have revealed a range of Treg cell activation an
Autor:
Naganari Ohkura, Shota Nakamura, Yukinori Okada, Yoshiaki Yasumizu, Yamami Nakamura, Yohko Kitagawa, Daisuke Motooka, Atsushi Tanaka, Shimon Sakaguchi
Publikováno v:
Immunity. 52:1119-1132.e4
The contribution of FOXP3-expressing naturally occurring regulatory T (Treg) cells to common polygenic autoimmune diseases remains ambiguous. Here, we characterized genome-wide epigenetic profiles (CpG methylation and histone modifications) of human
Autor:
Tomohiro Kurosaki, Axel Kallies, Stephen L. Nutt, Hiroyoshi Nishikawa, Shimon Sakaguchi, Kiyoshi Takeda, Yoshihiro Baba, Akemi Baba, Yasuyuki Ohkawa, Takafumi Yokota, Hisako Kayama, Masanori Matsumoto
Publikováno v:
Immunity. 41(6):1040-1051
SummaryB cells can suppress autoimmunity by secreting interleukin-10 (IL-10). Although subpopulations of splenic B lineage cells are reported to express IL-10 in vitro, the identity of IL-10-producing B cells with regulatory function in vivo remains
Publikováno v:
Immunity. 38(3):414-423
Regulatory T (Treg) cells are a developmentally and functionally distinct T cell subpopulation that is engaged in sustaining immunological self-tolerance and homeostasis. The transcription factor Foxp3 plays a key role in Treg cell development and fu
Autor:
Mayumi Matsuura, Hiromu Ito, Hitomi Watanabe, Keiji Hirota, Masaomi Tanaka, Alexandre J. Potocnik, Atsushi Tanaka, Noriko Sakaguchi, Motomu Hashimoto, Yoshinaga Ito, Keiko Yasuda, Gen Kondoh, Shimon Sakaguchi, Manfred Kopf, Brigitta Stockinger
Publikováno v:
Immunity, 48 (6)
Hirota, K, Hashimoto, M, Ito, Y, Matsuura, M, Ito, H, Tanaka, M, Watanabe, H, Kondoh, G, Tanaka, A, Yasuda, K, Kopf, M, Potocnik, A J, Stockinger, B, Sakaguchi, N & Sakaguchi, S 2018, ' Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis ', Immunity, vol. 48, no. 6, pp. 1220-1232.e5 . https://doi.org/10.1016/j.immuni.2018.04.009
Hirota, K, Hashimoto, M, Ito, Y, Matsuura, M, Ito, H, Tanaka, M, Watanabe, H, Kondoh, G, Tanaka, A, Yasuda, K, Kopf, M, Potocnik, A J, Stockinger, B, Sakaguchi, N & Sakaguchi, S 2018, ' Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis ', Immunity, vol. 48, no. 6, pp. 1220-1232.e5 . https://doi.org/10.1016/j.immuni.2018.04.009
Despite the importance of Th17 cells in autoimmune diseases, it remains unclear how they control other inflammatory cells in autoimmune tissue damage. Using a model of spontaneous autoimmune arthritis, we showed that arthritogenic Th17 cells stimulat
Autor:
Ichiro Taniuchi, Yoshinori Naoe, Tomoyuki Yamaguchi, Akihiko Kitoh, Masahiro Ono, Naganari Ohkura, Takashi Nomura, Shimon Sakaguchi, Issay Kitabayashi, Toshihiko Tsukada, Hiroko Yaguchi, Yoshiki Miyachi
Publikováno v:
Immunity. 31(4):609-620
SummaryNaturally arising regulatory T (Treg) cells express the transcription factor FoxP3, which critically controls the development and function of Treg cells. FoxP3 interacts with another transcription factor Runx1 (also known as AML1). Here, we sh
Autor:
Masahiro Ono, Alexis Mathian, Zahir Amoura, Cécile Taflin, Yumiko Yoshioka, Kajsa Wing, Shimon Sakaguchi, Toshio Heike, Christophe Parizot, Dominique Valeyre, Makoto Miyara, Tomoyuki Yamaguchi, Akihiko Kitoh, Tomoko Shima, Takashi Nomura, Akira Niwa, Tatsutoshi Nakahata, Guy Gorochov
Publikováno v:
Immunity. 30:899-911
FoxP3 is a key transcription factor for the development and function of natural CD4(+) regulatory T cells (Treg cells). Here we show that human FoxP3(+)CD4(+) T cells were composed of three phenotypically and functionally distinct subpopulations: CD4
Autor:
Ulf Dittmer, Hong He, Anke R. M. Olbrich, Shimon Sakaguchi, Ronald J. Messer, Simone Schimmer, Ingunn M. Stromnes, Karin E. Peterson, Kim J. Hasenkrug, Leonard H. Evans, Philip D. Greenberg, Claes Öhlén, Guojun Yang, Michihiro Iwashiro
Publikováno v:
Immunity. 20:293-303
The establishment of viral persistence generally requires evasion of the host CD8(+) T cell response. Here we describe a form of evasion wherein the CD8(+) T cells are fully capable of recognizing their cognate antigen but their effector functions ar