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pro vyhledávání: '"Neophytos Kouphou"'
Autor:
Laura E. McCoy, Jeffrey Seow, Thomas A. Bowden, Helen M. E. Duyvesteyn, Jose M. Jimenez-Guardeño, Hataf Khan, Neophytos Kouphou, Yuguang Zhao, Marit J. van Gils, Yin Wu, Carl Graham, Peter Cherepanov, Maria Jose Lista, Adam Laing, Manu Shankar-Hari, Liane Dupont, Weng M Ng, Adrian Hayday, Stuart J. D. Neil, Michael H. Malim, Luke Muir, Sam Acors, Annachiara Rosa, Magdalene Joseph, Helena Winstone, Katie J. Doores, Rui Pedro Galão, Isabella Huettner, Suzanne Pickering
Publikováno v:
Immunity, 54(6), 1276-1289.e6. Cell Press
Immunity
Graham, C, Seow, J, Huettner, I, Khan, H, Kouphou, N, Acors, S, Winstone, H, Pickering, S, Galao, R P, Dupont, L, Lista, M J, Jimenez-Guardeño, J M, Laing, A G, Wu, Y, Joseph, M, Muir, L, van Gils, M J, Ng, W M, Duyvesteyn, H M E, Zhao, Y, Bowden, T A, Shankar-Hari, M, Rosa, A, Cherepanov, P, McCoy, L E, Hayday, A C, Neil, S J D, Malim, M H & Doores, K J 2021, ' Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant ', Immunity, vol. 54, no. 6, pp. 1276-1289.e6 . https://doi.org/10.1016/j.immuni.2021.03.023
Immunity
Graham, C, Seow, J, Huettner, I, Khan, H, Kouphou, N, Acors, S, Winstone, H, Pickering, S, Galao, R P, Dupont, L, Lista, M J, Jimenez-Guardeño, J M, Laing, A G, Wu, Y, Joseph, M, Muir, L, van Gils, M J, Ng, W M, Duyvesteyn, H M E, Zhao, Y, Bowden, T A, Shankar-Hari, M, Rosa, A, Cherepanov, P, McCoy, L E, Hayday, A C, Neil, S J D, Malim, M H & Doores, K J 2021, ' Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant ', Immunity, vol. 54, no. 6, pp. 1276-1289.e6 . https://doi.org/10.1016/j.immuni.2021.03.023
Interaction of the SARS-CoV-2 Spike receptor binding domain (RBD) with the receptor ACE2 on host cells is essential for viral entry. RBD is the dominant target for neutralizing antibodies, and several neutralizing epitopes on RBD have been molecularl