Zobrazeno 1 - 10
of 61
pro vyhledávání: ''
Autor:
Darren R. Heintzman, Alanna M. Cameron, Samantha N. Freedman, Juan C. Garcia-Canaveras, Kelsey Voss, Arissa Young, Gabriela Andrejeva, Xiang Ye, Patrik Foerch, Jeffrey C. Rathmell, Katherine L. Beier, Allison E. Sewell, Dalton Greenwood, Ayaka Sugiura, Melissa M. Wolf, Xincheng Xu, Dawn C. Newcomb, Matthew Z. Madden, Shailesh K. Shahi, John Karijolich, Joshua D. Rabinowitz, Ashutosh K. Mangalam, Nowrin U. Chowdhury, Tim Bourne
Publikováno v:
Immunity. 55:65-81.e9
Summary Antigenic stimulation promotes T cell metabolic reprogramming to meet increased biosynthetic, bioenergetic, and signaling demands. We show that the one-carbon (1C) metabolism enzyme methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) regulates
Autor:
Maya E. Kotas, Richard M. Locksley
Publikováno v:
Immunity, vol 48, iss 6
Innate lymphoid cells (ILCs) are positioned in tissues perinatally, constitutively express receptors responsive to their organ microenvironments, and perform an arsenal of effector functions that overlap those of adaptive CD4+ Tcells. Based on knowle
Autor:
Michael Elliot, Mifong Tam, Ghislaine Fontes, Mary M. Stevenson, Alexandre P. Meli, Stuart G. Tangye, André Ballesteros-Tato, Scott A Leddon, Irah L. King, Danielle T. Avery, Deborah J. Fowell, James H. Miller
Publikováno v:
Immunity. 45:831-846
T follicular helper (Tfh) cells are a CD4+ T cell subset critical for long-lived humoral immunity. We hypothesized that integrins play a decisive role in Tfh cell biology. Here we show that Tfh cells expressed a highly active form of leukocyte functi
Autor:
Yayi Gao, Rémy Bosselut, Laura B. Chopp, Ferenc Livak, Caiyi Li, Marita Bosticardo, Thomas Ciucci, Sridhar Hannenhalli, Michael C. Kelly, Manon Lagarde, Francesca Pala, Zachary Rae, Allison Ruchinskas, Vishaka Gopalan
Publikováno v:
Immunity
αβ lineage T cells, most of which are CD4(+) or CD8(+) and recognize MHC I or MHC II-presented antigens, are essential for immune responses and develop from CD4(+)CD8(+) thymocytes. The absence of in vitro models and the heterogeneity of αβ thymo
Autor:
Tony Kiat Hon Lim, Eng Huat Tan, David E. Ong, Daniela Cerny, Frances Sheau Huei Lim, Florent Ginhoux, Katja Fink, Sriram Narayanan, Ern Yu Tan, Evan W. Newell, Wen Qi Ho, Michael Thomas Wong, Angela Takano, Bien Keem Tan, Maria A. Curotto de Lafaille, Karen Wei Weng Teng, Henry K.K. Tan, Jerry Kok Yen Chan, Peng Chung Cheow, John Kit Chung Tam, Rosslyn Anicete, Chung Yip Chan, Ser Yee Lee, Antonio Bertoletti, Naomi McGovern
Publikováno v:
Immunity. 45:442-456
Depending on the tissue microenvironment, T cells can differentiate into highly diverse subsets expressing unique trafficking receptors and cytokines. Studies of human lymphocytes have primarily focused on a limited number of parameters in blood, rep
Autor:
Michael H. Zhang, Stephanie Cheng, Bethany L. Mundy-Bosse, Tiffany Hughes, Karen A. Keller, Steven D. Scoville, Luxi Chen, Jianhua Yu, Susan McClory, Stephen M. Bergin, Michael A. Caligiuri, Li Chen, William E. Carson, Hsiaoyin C. Mao, Xiaoli Zhang, Aharon G. Freud
Publikováno v:
Immunity. 44:1140-1150
The current model of murine innate lymphoid cell (ILC) development holds that mouse ILCs are derived downstream of the common lymphoid progenitor through lineage-restricted progenitors. However, corresponding lineage-restricted progenitors in humans
Autor:
Katherine A. Fitzgerald, Paul J. Hertzog, Andrew G. Bowie, Ewa Oleszycka, Peter Andersen, Craig P. McEntee, Eimear M Lambe, Else Marie Agger, Natalia Muñoz-Wolf, Ed C. Lavelle, Samira Mansouri, Andres Mori, Lei Jin, Hannah B.T. Moran, Colm Cunningham, Elizabeth C. Carroll
Publikováno v:
Immunity. 44:597-608
The cationic polysaccharide chitosan is an attractive candidate adjuvant capable of driving potent cell-mediated immunity, but the mechanism by which it acts is not clear. We show that chitosan promotes dendritic cell maturation by inducing type I in
Autor:
Alma N. Mohebiany, Ari Waisman
Publikováno v:
Immunity. 47:10-12
In this issue of Immunity, Takata et al. (2017) describe a novel method to differentiate macrophages from iPSCs. These cells, which they call iMacs, are similar to yolk-sac-derived macrophages and are capable of undergoing terminal differentiation in
Autor:
Vi Luan Ha, Grigoriy Gogoshin, Andrei S. Rodin, Annie Luong, Sergio Branciamore, Jeong Eun Park, Virginia Camacho, Fan Li, Justin Le, Sweta B. Patel, Yong-Hwee Eddie Loh, Chintan Parekh, Robert S. Welner
Publikováno v:
Immunity
Summary The challenges in recapitulating in vivo human T cell development in laboratory models have posed a barrier to understanding human thymopoiesis. Here, we used single-cell RNA sequencing (sRNA-seq) to interrogate the rare CD34+ progenitor and
Autor:
Meinrad Busslinger, Esther Lutgens, Norbert Gerdes, Tomoyoshi Yamano, Jelena Nedjic, Benedikt Brors, Madlen Steinert, Maria Hinterberger, Sheena Pinto, Naozumi Ishimaru, Sandra D Koser, Bruno Kyewski, Ludger Klein
Publikováno v:
Immunity, 42(6), 1048-1061. Cell Press
Summary Thymic antigen-presenting cells (APCs) such as dendritic cells and medullary thymic epithelial cells (mTECs) use distinct strategies of self-antigen expression and presentation to mediate central tolerance. The thymus also harbors B cells; wh