Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Preclinical research"'
Publikováno v:
ILAR journal. 61(1)
Publikováno v:
ILAR journal. 62(1-2)
The failure of animal studies to translate to effective clinical therapeutics has driven efforts to identify underlying cause and develop solutions that improve the reproducibility and translatability of preclinical research. Common issues revolve ar
Autor:
Emily K. Colvin, Amanda L. Hudson
Publikováno v:
ILAR journal. 57(1)
The SV40 viral oncogene has been used since the 1970s as a reliable and reproducible method to generate transgenic mouse models. This seminal discovery has taught us an immense amount about how tumorigenesis occurs, and its success has led to the evo
Autor:
Michael F. W. Festing
Publikováno v:
ILAR journal. 55(3)
Inbred strains of mice such as C57BL and BALB/c are more widely used in published work than outbred stocks of mice such as ICR and CD-1. In contrast, outbred stocks of rats such as Wistar and Sprague-Dawley are more widely used than inbred strains su
Autor:
Adelaide Greco, Sara Gargiulo, Arturo Brunetti, Matteo Gramanzini, Giancarlo Vesce, Silvia Esposito, Andrea Affuso
Publikováno v:
Scopus-Elsevier
Animal experiments are necessary for a better understanding of diseases and for developing new therapeutic strategies. The mouse (Mus musculus) is currently the most popular laboratory animal in biomedical research. Mice imaging procedures are increa
Autor:
Paola Locatelli, Anna Hnatiuk, Rubén P. Laguens, Alberto J. Crottogini, Oscar Mendiz, Lucía Fazzi, Fabián Salmo, Fernanda Daniela Olea
Publikováno v:
ILAR journal. 52(1)
Studies on cardiac regeneration require large mammalian models of dilated cardiomyopathy (DCM) after acute myocardial infarction (AMI), and pig and sheep models are increasingly used in this field of preclinical research. Given the large interindivid
Publikováno v:
ILAR journal. 44(2)
In experimental neurological models of brain injury, behavioral manipulations before and after the insult can have a major impact on molecular, anatomical, and functional outcome. Investigators using animals for preclinical research should keep in mi