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Publikováno v:
Hypertension research : official journal of the Japanese Society of Hypertension. 43(4)
Our previous studies have shown that the maternal hyperinflammatory response in pre-eclampsia lowered the eclampsia-like seizure threshold. Cyclosporin A (CsA), which is an effective immunosuppressant, could attenuate the inflammatory responses in LP
Autor:
Laia Pazó-Sayós, Emilio Delgado-Baeza, Pilar Rodríguez-Rodríguez, Rainer H. Böger, Nicole Lüneburg, Maria del Carmen González, Silvia M. Arribas, Begoña Quintana-Villamandos
Publikováno v:
Hypertension research : official journal of the Japanese Society of Hypertension. 42(10)
Our group previously demonstrated that dronedarone induces regression of left ventricular hypertrophy in spontaneously hypertensive rats (SHRs). We assessed changes in vascular remodeling and oxidative stress following short-term use of this agent. T
Autor:
Tomoko Yoshikawa, Takuya Kishi, Ko Takesue, Kenji Sunagawa, Keisuke Shinohara, Toyoshi Inoguchi, Noriyuki Sonoda, Yoshitaka Hirooka, Risa Shibata, Hiroyuki Tsutsui
Publikováno v:
Hypertension research : official journal of the Japanese Society of Hypertension. 40(7)
To prevent cardiovascular events in patients with diabetes mellitus (DM), it is essential to reduce arterial pressure (AP). Sodium-glucose cotransporter 2 inhibitor (SGLT2i) prevents cardiovascular events via the depressor response in patients with D
Autor:
Danni Tu, Karen M D’Souza, Lauren A Biwer, Taben M. Hale, Matthew J. Huentelman, Ali Abidali, Ashley L. Siniard, Matthew D. DeBoth
Publikováno v:
Hypertension research : official journal of the Japanese Society of Hypertension. 39(1)
We have previously demonstrated that angiotensin-converting enzyme (ACE) inhibition with enalapril produces persistent effects that protect against future nitric oxide synthase (NOS) inhibitor (L-arginine methyl ester, L-NAME)-induced cardiac dysfunc
Publikováno v:
Hypertension research : official journal of the Japanese Society of Hypertension. 38(2)
Reactive oxygen species (ROS) and antioxidant enzymes are required to maintain homeostasis. The loss of this balance can cause excessive ROS production and damage to the cardiovascular tissues. Angiotensin II receptor blockers (ARBs) and β-blockers
Autor:
John W. Funder
Publikováno v:
Hypertension research : official journal of the Japanese Society of Hypertension. 33(9)
Two clinical trials will be reviewed, RALES(1) and ILLUMINATE.(2) In RALES, low-dose spironolactone in addition to standard of care, produced a 30% improvement in survival in progressive heart failure, commonly assumed to reflect deleterious effects
Publikováno v:
Hypertension research : official journal of the Japanese Society of Hypertension. 32(10)
Although dexamethasone (DEX) is known to cause hypertension in humans and in animals, the hemodynamic characteristics of DEX-induced hypertension (DEX-HT) in the rat remain unclear. This study evaluated central and regional hemodynamics, and the role
Autor:
Geraldo D'oliveira Silva, Thiago da Silva Torres, Jorge José de Carvalho, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda
Publikováno v:
Hypertension research : official journal of the Japanese Society of Hypertension. 31(5)
This study investigated the effects of rosiglitazone on nutritionally programmed chronic disease, with a focus on blood pressure (BP) and aortic wall structural remodeling. Wistar pregnant rats were fed one of two diets: a normal protein diet (19% pr
Autor:
Rieko Mano, Atsushi Sakima, Tomoko Shinzato, Yusuke Ohya, Shuichi Takishita, Masanobu Yamazato, Minori Nakamoto
Publikováno v:
Hypertension research : official journal of the Japanese Society of Hypertension. 31(2)
Thiazolidinediones, which stimulate peroxisome proliferator-activated receptor gamma, have been shown to prevent cardiovascular injury. However, little is known about their effects on salt-sensitive hypertension. We thus investigated whether or not p
Autor:
Taro Matsumoto, Naohiko Kobayashi, Chii Yamamoto, Ryo Suzuki, Takahiro Ueno, En-Hui Yao, Akiko Tsunemi, Koichi Matsumoto, Mayumi Katakawa, Noboru Fukuda
Publikováno v:
Hypertension research : official journal of the Japanese Society of Hypertension. 30(11)
We evaluated the effects of the angiotensin II (Ang II) receptor blocker (ARB) losartan on the formation and number of endothelial progenitor cells (EPCs) in hypertensive rats. Wistar-Kyoto (WKY) rats and stroke-prone, spontaneously hypertensive rats