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Autor:
Masamitsu Iwasa, Chihiro Okamoto, Shinya Minatoguchi, Yoshihisa Yamada, Hisaaki Komaki, Masanori Kawasaki, Yuka Hayakawa, Shingo Minatoguchi, Kazuhiko Nishigaki, Hiromitsu Kanamori
Publikováno v:
Hypertension Research. 41:886-896
We examined whether the stimulation of the angiotensin II AT1 receptor increases the expression of the cardiac (pro)renin receptor ((P)RR) and its downstream signals and whether the blockade of the angiotensin II AT1 receptor by azilsartan decreases
Publikováno v:
Hypertension Research. 36:277-284
Increase in cerebrospinal fluid (CSF) Na(+) concentration ([Na(+)]) precedes hypertension and is a key step in the development of salt-induced hypertension. In the choroid plexus (CP), epithelial Na(+) channels (ENaCs) have an important role in Na(+)
Autor:
Zhice Xu, Caiping Mao, Li Cao, Anwen Zhou, Aiping Shi, Yujuan Liu, Lei Wu, Qi Fang, Hui Zhu, Shigang Li
Publikováno v:
Hypertension Research. 36:158-165
Antenatal malnutrition could be linked to hypertension and vascular diseases in fetal origins. This study determined the influence of maternal intake of high sucrose (HS) during pregnancy on vessel tone, intracellular Ca(2+) ([Ca(2+)](i)), K(+) chann
Autor:
Peili Bu, Xue-Qiang Zhao, Jun-Ni Liu, Yun Ti, Yun Zhang, Wei Zhang, Xiao-Yang Hou, Ming-Xiu Hao, Zhi-Hao Wang, Chuan-Bao Li
Publikováno v:
Hypertension Research. 34:354-360
Rosiglitazone, an important peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist, improves left ventricular (LV) hypertrophy in diet-induced hypercholesterolemic rats. However, the effects and underlying mechanisms of rosiglitazone on myoc
Autor:
Mutsumi Iwamoto, Shozo Kusachi, Yoshifumi Ninomiya, Takashi Ohtsuki, Ryoko Shinohata, Hiroko Ogawa, Satoshi Hirohata, Faruk O Hatipoglu, Kazuhide Yamamoto, Toru Miyoshi
Publikováno v:
Hypertension Research. 33:1305-1311
Connective tissue growth factor (CTGF) is a secreted protein that regulates fibrosis. We hypothesized that CTGF is induced in a pressure-overloaded (PO) heart and that blocking the angiotensin II type 1 receptor would reduce CTGF expression. Accordin
Autor:
Koichi Yamamoto, Ryosuke Oguro, Atsushi Shiota, Yuji Tatara, Masao Takeda, Yasushi Takeya, Mitsuru Ohishi, Norihiro Hayashi, Yoshihiro Iwamoto, Hiromi Rakugi
Publikováno v:
Hypertension Research. 33:1182-1185
To clarify the role of endogenous angiotensin (Ang)-converting enzyme 2 (ACE2) and its cleavage product, Ang 1-7, in the atherogenic stimulation of vascular cells, we investigated the effect of pharmacological inhibition of ACE2 and Mas, an Ang 1-7 r
Autor:
Kristina Krajcirovicova, Michal Zeman, Iveta Herichová, Katarína Stebelová, Miroslava Benova, Ludovit Paulis, Fedor Simko
Publikováno v:
Hypertension Research. 32:242-247
Melatonin plays a role in blood pressure (BP) control. The aim of this study was to determine whether melatonin concentrations and melatonin receptor levels are altered in L-NAME-treated, NO-deficient hypertensive rats. Two groups of male adult Wista